Protein Alignment CG12171 and Dhrs2

DIOPT Version :10

• Sequence 1: NP_649563.1
• Gene: CG12171 / 40690
• FlyBaseID: FBgn0037354
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_082066.2
• Gene: Dhrs2 / 71412
• MGIID: 1918662
• Length: 282
• Species: Mus musculus
• Alignment Length: 612
• Identity: 116/612 - (18%)
• Similarity: 198/612 - (32%)
• Gaps: 223/612 - (36%)

  Fly    45 PYPHNLSTARSLEQKVRSSGSH-----PATIA---LFDGKIHVGLDDEKLEL-LASSQNAVKV-- 98
            |.....||....|.|.:|.|..     ||.:.   ..||...:||:|.:.|| :.|||...|:
Mouse   159 PTASTSSTPGGKEHKKQSPGKELFAPVPAVVKEPFSLDGAQRLGLEDARGELSIDSSQIVSKLVQ 223

  Fly    99 ---------SSRDIAKTLIKK-EVGGTTVASTMKIAHA-------------------------AG 128
                     |.||   .|::| :|.......::.|.|.                         .|
Mouse   224 IREYIGKATSMRD---DLVEKNDVPANVERLSLLITHLKEQEKSYLRFLQKMLARENEDDDDDEG 285

  Fly   129 ISVFATGGIGGVHRGADQTFDVSADLQELSQTPVCVVCSGVKSILDIPKTVEYLETHSVNCIVYG 193
            .:|.:..|.|.|   |:.|   |.:|:..|:|....                   .|.|
Mouse   286 ATVDSAVGSGSV---AEST---SLNLEPRSETSSAT-------------------GHGV------ 319

  Fly   194 QENVFPSFFTRTSDRKAQFCTESLEEVVHLLKTSKSLGLPYGTILACPIPEKYAADGDAIQKAID 258
                               |.|..||:.::.|                       ..|.::|.::
Mouse   320 -------------------CREQKEELENMRK-----------------------QHDLLKKMLE 342

  Fly   259 QAVQEAIEQNIASQSVTPFILARVNELTQGASMATNI----ALLENNASIAGR-LAAKLCD---- 314
            |.     ||..|.|.....:||    :.|.|.:|..:    .:.|...|::|| :.::|.|
Mouse   343 QQ-----EQLRALQGRQAALLA----MQQSAELAIAVMDDTVVTETTGSVSGRSITSELNDELND 398

  Fly   315 -----RRPLTISQSQPTASTTRKPKVVSIGATIVDFE-----------------AITSEDVK--- 354
                 ...|..||||......|:.:.:|:...:....                 |.||:..|
Mouse   399 LIQRFHNQLHDSQSQVVPDNRRQAECLSLSREVCRSRTTHNSRGQLPSSAPLTTASTSDSAKLSK 463

  Fly   355 ----DDGGSYNGQVVQRMGGV---------ARNHADALARLGCDSVFISAIGDDNNG-HFFRQ-- 403
                .|......:::|.:..:         .::.:...||:|. |...|.:|.:.|| ...||
Mouse   464 LQELQDKKQTMDKILQELHSLRDQTLNNSSCQSVSQRSARVGM-SERPSVLGREGNGPRPVRQGS 527

  Fly   404 --------NSHKID-INRVKIISNKPTCTYLAVNVKGNVKYGIVTCEPLLSVITPSLVESNEDAL 459
                    |||..| :.::|.:..:..      .::..|:|...|.:.::..:..::.|.:|:..
Mouse   528 SSYTQIDDNSHSADKLRKLKEVHKRLN------ELRELVQYYEQTSDMVVDTVNENVKEEDEETE 586

  Fly   460 ESSDF-ILLDSNLS--VPVMARVLEIAKKHDKQVWLEPTDIDKVKKVFDTGLVGAVTAASPNANE 521
            :.|.| .:.||...  .|| ..:...|:......|::...:.|.:            :||.|.:.
Mouse   587 DGSLFEAMFDSEQENHEPV-TNIRNPAQPQTPSNWMDMNSLTKTR------------SASNNRDG 638

  Fly   522 FLKW---------AKLCHVSVDPSVID 539
            .|..         |.|..::: ||||:
Mouse   639 RLNTECEINNRSAANLRSLNI-PSVIE 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12171	NP_649563.1	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	47/254 (19%)
Dhrs2	NP_082066.2	Rossmann-fold NAD(P)(+)-binding proteins	35..277	CDD:473865	28/120 (23%)