Protein Alignment CG12171 and RDH8

DIOPT Version :10

• Sequence 1: NP_649563.1
• Gene: CG12171 / 40690
• FlyBaseID: FBgn0037354
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_056540.3
• Gene: RDH8 / 50700
• HGNCID: 14423
• Length: 311
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 67/197 - (34%)
• Similarity: 103/197 - (52%)
• Gaps: 19/197 - (9%)

  Fly     7 KVIIVTGASSGIGAGTSVLLA---KLGGLLTIVGRNLDKLNETAEQIVAAGGA--PALQVA-ADI 65
            :.::::|.|||||...:|.||   |....:....|:|.| .||.|  .|||.|  ..|.|| .|:
Human     6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGK-KETLE--AAAGEALGQTLTVAQLDV 67

  Fly    66 NSESDVQGIVSATLAKHGRIDVLVNNAGILELGSIENTSLEQFDRVMNTNVRSLYQLTHLVTPEL 130
            .|:..|...:|..   .|.:||||||||:..:|.:|..||.....|.:||.....:|...|.|.:
Human    68 CSDESVAQCLSCI---QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGM 129

  Fly   131 IKTK-GNIVNVSSVNGIRSFPGVL---AYNVSKAAVDQFTRCVALELAPKGVRVNSVNPGVIITE 191
            .:.: |:||.:|||.|::   ||:   .|..||.|::.|...:|::|....:.::.|.||.::||
Human   130 KRRRQGHIVVISSVMGLQ---GVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTE 191

  Fly   192 LQ 193
            .:
Human   192 FE 193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12171	NP_649563.1	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	67/197 (34%)
RDH8	NP_056540.3	type1_17beta-HSD-like_SDR_c	6..262	CDD:187666	67/197 (34%)