Protein Alignment CG12171 and HSD17B1

DIOPT Version :10

• Sequence 1: NP_649563.1
• Gene: CG12171 / 40690
• FlyBaseID: FBgn0037354
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_001317148.1
• Gene: HSD17B1 / 3292
• HGNCID: 5210
• Length: 329
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 75/277 - (27%)
• Similarity: 119/277 - (42%)
• Gaps: 54/277 - (19%)

  Fly     8 VIIVTGASSGIGAGTSVLLA-------KLGGLLTIVGRNL---DKLNETAEQIVA-AGGAPALQV 61
            |:::||.|||||...:|.||       |:...|    |:|   .:|.|.|..:.. .|....||:
Human     5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATL----RDLKTQGRLWEAARALACPPGSLETLQL 65

  Fly    62 AADINSESDVQGIVSATLAK----HGRIDVLVNNAGILELGSIENTSLEQFDRVMNTNVRSLYQL 122
                    ||:...|...|:    .||:||||.|||:..||.:|....:....|::.||....::
Human    66 --------DVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122

  Fly   123 THLVTPELIKT-KGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVR-VNSVNP 185
            .....|::.:. .|.::...||.|:...|....|..||.|::.....:|:.|.|.||. ::.:..
Human   123 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHSLSLIEC 187

  Fly   186 GVIITE-LQRRGGLDQEA-----------YVKFLEHAK--VTHALGRPGEVKEVAAAIAFLASDE 236
            |.:.|. :::..|..:|.           :.::|.|:|  ...|...|.||.||     ||.:..
Human   188 GPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV-----FLTALR 247

  Fly   237 AS------FSTGISLPV 247
            |.      |:|...||:
Human   248 APKPTLRYFTTERFLPL 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12171	NP_649563.1	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	75/277 (27%)
HSD17B1	NP_001317148.1	Rossmann-fold NAD(P)(+)-binding proteins	4..262	CDD:473865	73/273 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	292..329