Protein Alignment CG12171 and Dhrs1

DIOPT Version :10

• Sequence 1: NP_649563.1
• Gene: CG12171 / 40690
• FlyBaseID: FBgn0037354
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_001007622.1
• Gene: Dhrs1 / 290234
• RGDID: 1359172
• Length: 313
• Species: Rattus norvegicus
• Alignment Length: 283
• Identity: 89/283 - (31%)
• Similarity: 130/283 - (45%)
• Gaps: 53/283 - (18%)

  Fly     3 SFKDKVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAADINS 67
            :.|.:|.:|||||.|||.|.::.|.:.|..:.|.||:||.|..||::..:.||. .:.|..|.:.
  Rat     4 TMKGQVCVVTGASRGIGRGIALQLCQAGATVYITGRHLDTLRATAQEAQSLGGR-CVPVVCDSSQ 67

  Fly    68 ESDVQGIV-SATLAKHGRIDVLVNN--AGILELGSIENTSLEQF--------DRVMNTNVRSLYQ 121
            ||:|:.:. .....:.||:||||||  ||:   .:|.||:.:.|        |.:.|..:|..|.
  Rat    68 ESEVKSLFEQVDREQQGRLDVLVNNAYAGV---QAILNTTTKSFWEAPASLWDDINNVGLRGHYL 129

  Fly   122 LT----HLVTPELIKTKGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVNS 182
            .:    .|:.|   ..||.||.|||..|::....| .|.|.|||.|:.....|.||...||...|
  Rat   130 CSVYGARLMVP---AGKGLIVVVSSPGGLQHMFNV-PYGVGKAACDKLAADCAHELRRHGVSYVS 190

  Fly   183 VNPGVIITELQRRGGLDQE-----AYVKF---LEHAKVTHALGRPGEVKEVAAAIAFLASDEASF 239
            :.||::.||:.:.....:|     .:.|.   |..|:.|...|:         .:..||:|....
  Rat   191 LWPGLVQTEMVKEYVAKEEQPEDPLFKKMKSVLSSAETTEMSGK---------CVVALATDPNIL 246

  Fly   240 S-TGISLP------------VDG 249
            | :|..||            |||
  Rat   247 SLSGKVLPSCDLARRYGLKDVDG 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12171	NP_649563.1	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	89/282 (32%)
Dhrs1	NP_001007622.1	DHRS1-like_SDR_c	5..271	CDD:187664	89/282 (32%)