Protein Alignment CG12171 and Hsd17b1

DIOPT Version :10

• Sequence 1: NP_649563.1
• Gene: CG12171 / 40690
• FlyBaseID: FBgn0037354
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_034605.1
• Gene: Hsd17b1 / 15485
• MGIID: 105077
• Length: 344
• Species: Mus musculus
• Alignment Length: 275
• Identity: 75/275 - (27%)
• Similarity: 114/275 - (41%)
• Gaps: 52/275 - (18%)

  Fly     8 VIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLD-KLNETAEQIVAAGGAPALQVAADINS---- 67
            |:::||.|||||...:|.||.        .|:.. |:..|...:.|.|  |.|:.|.....
Mouse     5 VVLITGCSSGIGMHLAVRLAS--------DRSQSFKVYATLRDLKAQG--PLLEAARTQGCPPGS 59

  Fly    68 ----ESDVQGIVSATLAK----HGRIDVLVNNAGILELGSIENTSLEQFDRVMNTNVRSLYQLTH 124
                |.||:...|...|:    .||:||||.|||....|.:|...|.....|::.||....::..
Mouse    60 LEILELDVRDSKSVAAAQACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQ 124

  Fly   125 LVTPELIKT-KGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVNSVNPGVI 188
            ...|::.:. .|.::..:||.|:...|....|..||.|::.....:|:.|...||.|:.:..|.:
Mouse   125 AFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAV 189

  Fly   189 ITELQRR-----GGLDQEA----------YVKFLEHAKVTHALGRPGEVKEVAAAIAFLASDEAS 238
            .|....:     ||..:.|          |::..|.| ::.|.. |.||.|:     ||.:..|.
Mouse   190 HTAFYEKLVGGPGGALERADAQTRHLFAHYLRGYEQA-LSEAQD-PEEVTEL-----FLTAMRAP 247

  Fly   239 ------FSTGISLPV 247
                  |||...||:
Mouse   248 QPALRYFSTNRFLPL 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12171	NP_649563.1	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	75/275 (27%)
Hsd17b1	NP_034605.1	Rossmann-fold NAD(P)(+)-binding proteins	4..260	CDD:473865	73/271 (27%)