Protein Alignment CG31549 and HSD17B8

DIOPT Version :10

• Sequence 1: NP_730972.2
• Gene: CG31549 / 40689
• FlyBaseID: FBgn0051549
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_055049.1
• Gene: HSD17B8 / 7923
• HGNCID: 3554
• Length: 261
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 79/260 - (30%)
• Similarity: 126/260 - (48%)
• Gaps: 25/260 - (9%)

  Fly     5 KDKVIIVTGASSGIGASAAVHLAKLGGLLVIVGRNEEKLKETADNIVAAGGATPLE--------- 60
            :..:.:||||.||||.:.:|.||..|..:.....:....:||   :...||....|
Human    10 RSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQET---VRLLGGPGSKEGPPRGNHAA 71

  Fly    61 LQADMTKEAEVQQIVGATLAKHGR-IDVLVNNAGILETGSIEATSLEQFDRLMNTNVRSLYQLTM 124
            .|||:::....:.::....|...| ..|:|:.|||.:...:...|.:.:|:::..|::..:.:|.
Human    72 FQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQ 136

  Fly   125 LATPELVKT--KGNIVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGV 187
            .|...||..  :|:|:|:||:.|.....|...|..|||.|...|...|.||...|:|.|:|.||.
Human   137 AAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGF 201

  Fly   188 IVTDIHKRGGMDEETYAKFLEHCKITH--ALGRPGDVKEVAAAIAFLASDQASFTTGISLPVDGG 250
            |.|.      |.::...|.::  |||.  .:|..||.::||..:|||||:.:.:.||.|:.|.||
Human   202 IATP------MTQKVPQKVVD--KITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGG 258

  Fly   251  250
            Human   259  258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31549	NP_730972.2	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	79/260 (30%)
HSD17B8	NP_055049.1	BKR_SDR_c	13..260	CDD:187594	79/257 (31%)