Protein Alignment CG31549 and HSD17B14

DIOPT Version :10

• Sequence 1: NP_730972.2
• Gene: CG31549 / 40689
• FlyBaseID: FBgn0051549
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_057330.2
• Gene: HSD17B14 / 51171
• HGNCID: 23238
• Length: 270
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 92/267 - (34%)
• Similarity: 130/267 - (48%)
• Gaps: 45/267 - (16%)

  Fly     4 FKDKVIIVTGASSGIGASAAVHLAKLGGLLVIVGRNEEKLKETADNIVAAGGATPLELQ------ 62
            :..||::|||...||||.........|..:||..::|           :.|.|...||.
Human     7 YAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDE-----------SGGRALEQELPGAVFIL 60

  Fly    63 ADMTKEAEVQQIVGATLAKHGRIDVLVNNAGILETGS-IEATSLEQFDRLMNTNVRSLYQLTMLA 126
            .|:|:|.:|:.:|..|:.:.||:|.:|||||...... .|.||.:.|.:|:..|:...|.||.||
Human    61 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125

  Fly   127 TPELVKTKGNIVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGVIVTD 191
            .|.|.|::||::|:||:.|.......:.|..:|.||...|..:||:.:|.|||||.::||.|.|.
Human   126 LPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTP 190

  Fly   192 IHK-------------RGGMDEETYAKFLEHCKITHALGRPGDVKEVAAAIAFLASDQASFTTGI 243
            :.:             |.||             :...|||.|...||.||..|||| :|:|.|||
Human   191 LWEELAALMPDPRATIREGM-------------LAQPLGRMGQPAEVGAAAVFLAS-EANFCTGI 241

  Fly   244 SLPVDGG 250
            .|.|.||
Human   242 ELLVTGG 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31549	NP_730972.2	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	92/267 (34%)
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	92/267 (34%)