DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31549 and DHRS4L2

DIOPT Version :9

Sequence 1:	NP_001262292.1	Gene:	CG31549 / 40689	FlyBaseID:	FBgn0051549	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_932349.2	Gene:	DHRS4L2 / 317749	HGNCID:	19731	Length:	232	Species:	Homo sapiens

Alignment Length:	184	Identity:	57/184 - (30%)
Similarity:	98/184 - (53%)	Gaps:	9/184 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DKVIIVTGASSGIGASAAVHLAKLGGLLVIVGRNEEKLKETADNIVA---AGGATPLELQADMTK 67
            :||.:||.::.|||.:.|..||:....:|:..|.::.:    |..||   ..|.:.......:.|
Human    32 NKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNV----DQAVATLQGEGLSVTGTVCHVGK 92

  Fly    68 EAEVQQIVGATLAKHGRIDVLVNNAGILE-TGSIEATSLEQFDRLMNTNVRSLYQLTMLATPELV 131
            ..:.:::|...:..||.||:||:||.:.. .||:...:.|.:|:.::.||::...:|....||:.
Human    93 AEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEME 157

  Fly   132 KT-KGNIVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVN 184
            |. .|::|.|||:......||...|||||.|:......:|:||||:.:|||.::
Human   158 KRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNCLH 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31549	NP_001262292.1	NADB_Rossmann	4..254	CDD:304358	57/184 (31%)
CG31549	NP_001262292.1	fabG	4..251	CDD:235975	57/184 (31%)
DHRS4L2	NP_932349.2	NADB_Rossmann	24..>210	CDD:304358	57/181 (31%)
DHRS4L2	NP_932349.2	adh_short	33..210	CDD:278532	57/180 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140593
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000019
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.830