DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atu and leo1

DIOPT Version :9

Sequence 1:	NP_524240.1	Gene:	Atu / 40684	FlyBaseID:	FBgn0019637	Length:	725	Species:	Drosophila melanogaster
Sequence 2:	NP_996950.1	Gene:	leo1 / 404599	ZFINID:	ZDB-GENE-040426-2435	Length:	696	Species:	Danio rerio

Alignment Length:	760	Identity:	290/760 - (38%)
Similarity:	388/760 - (51%)	Gaps:	137/760 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GSAPGSQRSRRSGSGSDRSRSGSRSSRSRSGSGSPRSARSGSAESRHSQLSGSARSKRSRSAHSR 92
            |.:...||...||||||......||:.:.||                   |.||:|.|.......
Zfish    12 GDSDNEQRDSGSGSGSDSDHERPRSASNASG-------------------SESAQSDRDHDDDED 57

  Fly    93 RSGSARSRKS--GTPESPQSHRSGSLQSRKSGSPQSRRSGSPQSRKSGSTH--SRRSGSAH---- 149
            ..|...|.|.  | .:|...|.|....|:.||   ||.||   ||.|||.|  ||.|||.|
Zfish    58 EDGGKPSNKELFG-DDSEDEHGSQHSGSQHSG---SRHSG---SRHSGSRHSGSRHSGSQHSGSQ 115

  Fly   150 SRRSGSARSRKSGSAQSDRSESRSRSHSGSLKGNEESRSNSPNLQIDVERANSKSGSRSRSR--- 211
            |.|||   ::...:..||...|.|.:|.|.   .::...:....:.||....|.:|||...|
Zfish   116 SERSG---NQSDATMHSDNEHSMSEAHRGE---QDDEDDDDRGHRSDVGSPASGAGSRRSDRGSG 174

  Fly   212 ---SRSGSRTSRS---RSKTGTPSPNRSRSGSASGSG---------SDVGVPKKK------ARKA 255
               |.:||..|.:   .|..|||..:...||..:.||         ||....:.|      .|:.
Zfish   175 SPGSEAGSPRSEAGSGHSDPGTPHTDGEGSGKDAHSGDEKWGGDGKSDQSEDEDKQQNSDDERER 239

  Fly   256 SGSDQEKKKSGS--DSDIEESPTKAKKSRLI-DTDSDSNQDV-GKKAPAAADIFGDADDISDDED 316
            |..:.|::||.|  .||.|:..|:.||.::. |:||||:.:. |.|.|||.|:||:|||||.|.|
Zfish   240 SDEEGERQKSESIKGSDSEDDFTRKKKKKIASDSDSDSDAETQGGKKPAANDLFGEADDISSDSD 304

  Fly   317 EAGPAARKSPVRSKSRSQSKSHSHSRSMSHSRSRSRSRSRDKVESQVESAPKEDEPEPLPETRID 381
            ...|.....|:.:.                          |.:|..      :.|.||.|||||:
Zfish   305 AEKPLTPGQPLDAD--------------------------DGMEGD------QPEEEPAPETRIE 337

  Fly   382 VEIPRISADLGKEQHFIKLPNFLSVVTHPFDPETYEDEIDEEETMDEEGRQRIKLKVSNTIRWRE 446
            ||||::|.|||.:.:|:||||||||...||||:.||||.::||.:|||||.|:||||.||||||.
Zfish   338 VEIPKVSTDLGSDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRS 402

  Fly   447 YMNNKGDMVRESNARFVRWSDGSMSLHLGNEIFDAYRQPLLGDHNHLFVRQGTGLQGQSVFRTKL 511
            ..:.:|:.|:|||||.|:|||||||||||||:||.|:.||.|||||||:|||||||||:||:|||
Zfish   403 RRDEEGNEVKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKL 467

  Fly   512 TFRPHSTESFTHKKMTMSLADRSSKTSGIKILTQVGKDPTTDRPTQLREEEAKLRQAMR---NQH 573
            |||||||:|.||:|||:|||||.|||..|:||...|:||.:.|...:::||.:||.::|   .|.
Zfish   468 TFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPESQRNEMIKKEEERLRASIRRESQQR 532

  Fly   574 KSLPKKKKPGAGEPLIGGGTSSYQHDEGSDDENAISLSAIKNRYKKGSGAGQAEVKASTIYSSDE 638
            :...|:.:.|    |..|.....::||..:.|.:|||:|||::||.|.|..:...:   |||||.
Zfish   533 RMREKQHQRG----LNAGYLEPDRYDEDEEGEESISLAAIKSKYKGGGGLREERAR---IYSSDS 590

  Fly   639 DEGSDFE--------------------ARRSKKVDKAKASKALRD---SDSESDAGSAKSGHSNK 680
            |||||.:                    .:|..:.|:..|||..:.   ||.|.:.|..:.....:
Zfish   591 DEGSDEDKAQRLMKAKRLDSDEEGENSGKRKAEEDEESASKKPKKYVISDEEDEDGDGERDGDRE 655

  Fly   681 SGGEGGSASGSENEGSQKSGGGSSKSASGSGSGSGSGSGSGSDND 725
            .||:    ...:.:|..:..|...:.....|.|.|.|.|.|.:::
Zfish   656 RGGD----MDGDGDGDMEGDGDVDRDGDMDGDGEGDGEGDGEEDE 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atu	NP_524240.1	Leo1	396..550	CDD:281933	107/153 (70%)
leo1	NP_996950.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..336		118/387 (30%)
		PHA02664	<161..260	CDD:177447	29/98 (30%)
		Leo1	352..510	CDD:281933	109/157 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..560		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..696		29/118 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579789
Domainoid	1	1.000	241	1.000	Domainoid score	I2201
eggNOG	1	0.900	-	-		E1_KOG2428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1774
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004097
OrthoInspector	1	1.000	-	-		oto38764
orthoMCL	1	0.900	-	-		OOG6_104699
Panther	1	1.100	-	-	LDO	PTHR23146
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1979
SonicParanoid	1	1.000	-	-		X4466
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.780