DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rga and Cnot2

DIOPT Version :9

Sequence 1:	NP_730966.1	Gene:	Rga / 40683	FlyBaseID:	FBgn0017550	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_006241425.1	Gene:	Cnot2 / 299805	RGDID:	1311672	Length:	550	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	194/594 - (32%)
Similarity:	276/594 - (46%)	Gaps:	163/594 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANLNFQQPPRSIANAALAGRTTGGFGGSSLAGHVTPTSGMFQTDFANSYPGTANYGQAPQQQQQ 65
            |:| |..|..||::.            |:.|..|||||:|:  ...:...|.:.:.|..|...:.
  Rat    99 MSN-NTPQLNRSLSQ------------GTQLPSHVTPTTGV--PTMSLHTPPSPSRGILPMNPRN 148

  Fly    66 QQQQPQLS-----PNRNAQLSVGGPAISSGNRNAN--LFGQRQFVERRAMQGLGSGPMSNMGNFM 123
            .....|:.     |:|...:|..|  :.|.||::.  :...:|...|:.              |.
  Rat   149 MMNHSQVGQGIGIPSRTNSMSSSG--LGSPNRSSPSIICMPKQQPSRQP--------------FT 197

  Fly   124 QTGRGGYGTGGGGGGPLNN---FHVFGGGGGSDTSTPALLDPTEFPSLT--NARGQNDQTLPQSN 183
            .....|:|........:||   .::|.|..||:..|.  ||.::||:|.  |.|..:....|..|
  Rat   198 VNSMSGFGMNRNQAFGMNNSLSSNIFNGTDGSENVTG--LDLSDFPALADRNRREGSGNPTPLIN 260

  Fly   184 PLQPPGSKPYGNFFTSFGMVKQPTSEQS-EFTMSNEDFPALPGTQNSDGTTNAVGSVAGTGGSGG 247
            ||  .|..||      .|||.:|.:||| :|::.|||||||||:...|.|::...|.:....||
  Rat   261 PL--AGRAPY------VGMVTKPANEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLSTSG- 316

  Fly   248 ASTENHLDGTEKPMNSIVVSGSASGSSGSNVGVVGGNGLGAVGSGIGGLAVGGGGGAGSSGGGGV 312
             .|.:..||.:.|
  Rat   317 -KTTSSTDGPKFP---------------------------------------------------- 328

  Fly   313 GGNAASGVVGGSHVGLVGSNSGIGGVNSVPNSNAMMGVGGGLGSGSGSSGSGAGGEHLNDNSSND 377
                                                        |..||           .:.|:
  Rat   329 --------------------------------------------GDKSS-----------TTQNN 338

  Fly   378 KLVKSGVQTSPDGKVTNIPATMVNNQFGMVGLLTFIRAAETDPNLVTLSLGTDLTGLGLNLNSQE 442
            ...|.|:|..|||:|||||..||.:||||:|||||||||||||.:|.|:||:|||.|||||||.|
  Rat   339 NQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPE 403

  Fly   443 SLHTTFAGPFVAQPCRAQDVEFNVPPEYLINFAIRDKLTAPVLKKLQEDLLFFLFYTNIGDMMQL 507
            :|:..||.|:.:.|||.||::|:||.|||.|..|||||.|..|.:..|||||:|:|.|.||::||
  Rat   404 NLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQL 468

  Fly   508 MAAAELHSREWRYHVEEKIWITRIPGIDQYEKNGTKERGTFYYFDAQSWKRLSKVFQIDPEKLDK 572
            :||.||.:|:||||.||::||||.||::...|..|.||||:|:||..:|::::|.|.::.:||::
  Rat   469 LAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEE 533

  Fly   573 CPNISAFMN 581
            .|::.:..|
  Rat   534 RPHLPSTFN 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rga	NP_730966.1	NOT2_3_5	445..568	CDD:282064	63/122 (52%)
Cnot2	XP_006241425.1	NOT2_3_5	406..529	CDD:398019	63/122 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344923
Domainoid	1	1.000	150	1.000	Domainoid score	I4290
eggNOG	1	0.900	-	-		E1_COG5601
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273874at2759
OrthoFinder	1	1.000	-	-		FOG0003536
OrthoInspector	1	1.000	-	-		oto95678
orthoMCL	1	0.900	-	-		OOG6_101639
Panther	1	1.100	-	-	LDO	PTHR23326
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2412
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.750