DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment asl and Cep152

DIOPT Version :9

Sequence 1:	NP_649557.2	Gene:	asl / 40682	FlyBaseID:	FBgn0261004	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001074560.1	Gene:	Cep152 / 99100	MGIID:	2139083	Length:	1736	Species:	Mus musculus

Alignment Length:	1136	Identity:	247/1136 - (21%)
Similarity:	451/1136 - (39%)	Gaps:	339/1136 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DDAQRANEIEMHRLQILLESKNNELQNVNQVANAAHKKLDDLQKHLSIMQAELD---RAIREK-- 147
            ::...|..|.:.:||:|.::|..:|.::.:....:.:::..|...|.|:|.|.|   .::||.
Mouse   218 NETDSAENIHIIQLQVLNKAKERQLDSLVEKLKDSERQVRYLSHQLLIVQDEKDGLALSLRESQQ 282

  Fly   148 --QNTHELLVETKETCSNKDSDLDKLR-SEKKQLEEDNTRLVGQLEAAKTLLTDVQSKYDMVQAS 209
              ||..|..::.:...:..::.::..| ||:|..::..|..: .||:.|..|.::... :.:|.:
Mouse   283 LFQNGKEREMQLEAQIAALEAQVEAFRVSEEKLTKKLRTTEI-TLESLKQQLVELHHS-ESLQRA 345

  Fly   210 KQKWEERNADLRLKQMEEAHRAQSDL------LQQQ--LC-QMKD---QLDRKQNELDQINSRYN 262
            ::..|...|.|..|..|:....|.:|      ||:|  :| ::||   ||:|.|
Mouse   346 REHHESIVASLTQKHEEQVSSLQKNLDATITALQEQESICTRLKDHVQQLERNQ----------- 399

  Fly   263 ALQSGHETMLVDKAAKINELSQALDEAQMRCNQL--------SARPDLQAE------------NR 307
                  |.:.::|...||.|:::|:::|.:|..|        .|:..||.:            |:
Mouse   400 ------EAVRLEKTELINRLTRSLEDSQKQCAHLLQSGSVQEVAQLQLQLQQAQKAHVLSESMNK 458

  Fly   308 RQQQCIVDLKARIAYLEQTV----------ASLHERLNETTTELDL---------IDSVIQQHQA 353
            ..|:.:.:||..|:..|...          ..|...|.|:..:|.:         .:.|.||...
Mouse   459 ALQEELTELKDEISLYESAAELGVLPGDSEGDLSIELTESCVDLGIKKVNWKQSKANRVTQQESP 523

  Fly   354 DESPTSRLSQMGGSRLVGSTPLNPLDRVGHIKQELYRALGNLKNKREEVRRLEKLLEERNQELRV 418
            ||.|:..                  :.:..:|.::.|.|.:...||..|.:|:..|.|..:.:..
Mouse   524 DEDPSKD------------------ELILKLKTQVQRLLTSNSVKRHLVSQLQSDLRECRETMEA 570

  Fly   419 LR-------------DQENQSLVQL-----ETLN-EGKMRLENKVKAMQ---QELE--EQKHRSQ 459
            .:             |...::..||     |.:| |..::|:|:|:.:|   |||:  |:|.||.
Mouse   571 FQQSKDGDSGMETKTDTSEKTTKQLWLESSEAINREDILQLKNEVQVLQKQNQELKEAEEKLRST 635

  Fly   460 QESDVHSQLNSIVAERDALREKRQQI-------EEDLEQLKQQ-NESLQRNYDQLSQENRQLRTR 516
            .: |:.:|:..:|.|.|  .:|::.:       ::..|.:|.| .|||...:  ..::...|...
Mouse   636 NQ-DLCNQMRQMVQEFD--HDKQEAVARCERTYQQHHEAMKAQIRESLLAKH--AVEKQHLLEVY 695

  Fly   517 E-TADNLRLELERHKILLRDSQSEVERLKKLYSDIATDKESLGYELRKLRESDTLKELQDQRQNL 580
            | |...||.:|::       ...|:..:::.|.::..:|:.|...|||     |:::.|:|::
Mouse   696 EGTQSQLRSDLDK-------MNKEMAAVQECYLEVCREKDGLESTLRK-----TMEKAQEQKR-- 746

  Fly   581 ATVQRNLQLAEMKSEELKKL-----------LETEKLS-------------HERDLQALRQRSER 621
                   ||.|.:.|.::||           |:||:.|             .:...|.|.|:.|:
Mouse   747 -------QLLEAREEYVRKLKLELEEKYQETLKTERQSWLQEQAAGATQQAEKESRQKLIQQLEK 804

  Fly   622 E---KREEAVAVAKESSENCSKCIESI---AEITKAEIQLLKLQNVNSMQAKELKELEHALEQSK 680
            |   |.::::|..::::.:.....|.:   |.::|||...: |....:.|.::.|||       .
Mouse   805 EWQSKLDDSLAAWRKTTSDRGSQTEQVACPAAVSKAEAAAV-LAEEQARQVQQEKEL-------A 861

  Fly   681 NLQAEMQEKIELSNKQDELISDLKERAKQ---------------FEAYIR--QQEEHKQQNKCTP 728
            ..:|..:.::||..|..|:|:...|.|.|               ::|.:|  |||..|||.....
Mouse   862 TKEALRKPEVELELKYCEIIAQKVETAVQNARSRWIQELPMLAEYKALLRAQQQEWAKQQELAVA 926

  Fly   729 SPKSNSVS--------------PSDPSPKELTQNRIRLIEQRVR---DEMAKLFAAELKRFTNRL 776
            ...|.::|              |:..|.||| :.::..:::.:.   :|:..:..||:.:.....
Mouse   927 HRLSLALSEAKEKWKSELENMKPNVMSVKEL-EEKVHSLQKELELKDEEVPVIVRAEVAKARTEW 990

  Fly   777 QKSEERSQCLQREYQTVCAELQQRQTEVDLLKQTILAERENIDEILAGREE---KQK-EML---- 833
            .|.:      |.|...:     |.|.|.| .:|.:...|..|:|:||..:|   ||| |:|
Mouse   991 NKEK------QEEIHKI-----QEQNEED-YRQFLEDHRNKINEVLAAAKEDFVKQKAELLLQKE 1043

  Fly   834 ---QKC----RQE--LQAKNQR--------------IAELLREVEEQHASIDSERQ---SMKAVM 872
               |.|    |:|  ||...|.              :|.||::.:.::.....::|   :|.|..
Mouse  1044 TEFQACLDQSRKEWTLQEAQQTQVEIRQYEEDTLTVLAYLLKDTQLEYGGDSQDKQLLEAMSACS 1108

  Fly   873 AQW------EKQRQSVDQVEHHWRQQL-ESLRSTHEE---------------------------- 902
            ::|      ||.:..:.:..|.....| :|:.|..|:
Mouse  1109 SKWISVQYFEKVKACIQKALHDMLSLLTDSVASEQEKRKVVKSSADTVSWTSSEGDSAVPVPLPD 1173

  Fly   903 --AMRSAQQRYQSA--KRTAHNYKLYAEDKE---AHMKREYERIKHEYELSLAKIEATMN--QHL 958
              ::|.||   .||  |..|...|...|.|.   .|..:|.|:.|.|.:....|:|....  |||
Mouse  1174 STSVRCAQ---SSAWLKAEAETDKKICEIKGLRCGHCFQELEKEKQECQDLRRKLEKCRRHLQHL 1235

  Fly   959 ERRSR------------------EKHRDKEN 971
            ||..|                  |::.|.:|
Mouse  1236 ERTHRAAVEKLGEENSRVVEELIEENHDMKN 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asl	NP_649557.2	SMC_prok_B	<97..709	CDD:274008	160/733 (22%)
		DUF342	<428..503	CDD:302792	28/93 (30%)
		GluZincin	484..>629	CDD:301352	38/180 (21%)
Cep152	NP_001074560.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127
		Interaction with PLK4. /evidence=ECO:0000250\|UniProtKB:O94986	1..60
		TBPIP	<281..386	CDD:284512	23/106 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..592		1/20 (5%)
		GBP_C	<610..803	CDD:303769	52/218 (24%)
		coiled coil	794..803	CDD:293879	3/8 (38%)
		ATP-synt_B	<977..1085	CDD:304375	30/119 (25%)
		NtpE	1298..>1422	CDD:224308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1416..1479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1574..1614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1677..1736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KJ0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900