DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment asl and cep152

DIOPT Version :9

Sequence 1:	NP_649557.2	Gene:	asl / 40682	FlyBaseID:	FBgn0261004	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_009296419.1	Gene:	cep152 / 565873	ZFINID:	ZDB-GENE-111005-1	Length:	1560	Species:	Danio rerio

Alignment Length:	1146	Identity:	250/1146 - (21%)
Similarity:	482/1146 - (42%)	Gaps:	252/1146 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GADALNINSTLDRQEEEE------ALQDQK--RREEELG---RIMVNAFDDLLDEENTIDSTTNY 64
            |.|..:.|   |...||:      |||.|.  ..||..|   :|.:.....:.:....::..|::
Zfish   147 GTDGSHAN---DFSTEEQSSFPHNALQHQPGYHEEEAQGHGEQISITNHIQVFNNGAAVNKPTDH 208

  Fly    65 QSELEQPPVLPNYPS--HPH-----------HKPLQDDAQR-ANEIEMHRLQILLESKNNELQNV 115
            .....||....|.|.  :|.           .:...|..|. |:..::.:||||.::::.::..:
Zfish   209 FKATYQPHQPSNQPKMFNPQVNNQNGRFDQLQRDFLDSTQNTADGQQLAQLQILKQAQSRQIDEL 273

  Fly   116 NQVANAAHKKLDDLQKHLSIMQAELDRAIREKQNTHELLVETKETCSNKDSDLD-KLRSEKKQLE 179
            .|......:::..::...:|::.|.|......:.:..|:.|.||    :::.|. ::|:.:||::
Zfish   274 EQKLEDCRRRMRYVEHQFAIVKDEKDGLAVSLKESSTLVEEAKE----REAQLQARIRALEKQIQ 334

  Fly   180 EDNTR---LVGQLEAAKTLLTDVQ------SKYDMVQASKQKWEERNADLRLKQMEEAHRAQSDL 235
            ....|   :|.|...|:..:..::      .:.|.:..::::.:...|.:|     |.:.|:...
Zfish   335 SLTDREQEIVKQQRVAEAAMDSMKLQMVELCRSDTLTRAREQHDRDTAAIR-----EQYEARLLT 394

  Fly   236 LQQQLCQMKDQLDRK----QNELDQINSRYNALQSGHETMLVDKAAKINELSQALDEAQMRCNQL 296
            |||:|....:.||::    |..|||:..    |:...|...:|:|:.||.|:..|:|:|.:|.:|
Zfish   395 LQQKLDSQSESLDKQAEAGQRLLDQVRQ----LERQREEDQMDRASVINTLTHRLEESQQQCAKL 455

  Fly   297 SARPDLQAENRRQQQCIVDLKARIAYLEQTVASLHERLNETTTELDLIDSVIQ----------QH 351
            .....:| |..:.|..:..:::.....|....:|.:.|:|...:::|.:|.|:          ::
Zfish   456 LHTGSVQ-EMSQLQMKLQQVQSARTISEDISKALQDELSELKEQINLYESAIKCGALESNGDWEN 519

  Fly   352 QADESPTS---RLSQMGGSRLVGSTP------LNPLDRVGHIKQELYRALGNLKNKR-------E 400
            |..||...   :.|:....| :.|||      |.. |.|..:|.||.|.|.:||:||       |
Zfish   520 QLSESYMDLGIKKSKWRNGR-IHSTPHISDSNLKE-DVVRELKNELQRCLSHLKSKRLKISELQE 582

  Fly   401 EVRRLE---KLLEERNQEL-RVLRDQENQSLVQLETLNEGKMRL--ENKVKAMQQELEEQKHRSQ 459
            |:||.:   :.||.|.|:. |.:||.:.:.....:.|.|.::..  :.::..:|:.||..:.|:|
Zfish   583 ELRRSQSRIETLETRIQQADRTIRDSQVRESSLEKQLEESQVTAGPQEELSRLQERLEVLEKRNQ 647

  Fly   460 QESDVHSQLNSIVAER-DALREKRQQIEEDLEQLKQQNESLQRNY---------DQLSQEN---- 510
            :......:|.::.:|. ..:||..|:::::.::..::||..|:.:         :||:||:
Zfish   648 ELKQSEDKLKAVNSELCTKMREMIQELDQEKQEAAERNERTQQQFRDDVVNGVREQLTQEHTAHI 712

  Fly   511 RQLRTRETADNLRLELERHKILLRDSQSEVERLKKLYSDIATDKESLGYEL-RKLRESDTLKE-- 572
            :||.::.     :.::::.:..|.|...||..:::.|..:..:|:.|...| .||.|..|.||
Zfish   713 QQLSSQH-----QQQIQQLQSKLTDLSQEVLAVQECYLAVCKEKDKLEENLHNKLEEERTSKEKE 772

  Fly   573 -LQDQRQNLATVQRNLQLAE-----MKSEELKKLLETEKLSHERDLQ---ALRQRSEREKR--EE 626
             ||...:......|.|...|     ..||...:|:..|:|..:...|   .||:.:..:.|  ||
Zfish   773 RLQKSEEEEVRKARQLDTCEGACQTSSSETAGRLISEEELEVQLGAQRDTLLREAAAAQSRAVEE 837

  Fly   627 AVAVA-----KESSENCSKCIE---------------------SIAEITKAEIQLLKLQNVNSMQ 665
            ||..|     ::.:|:.:..:|                     |..:..|||.:.|:.|:|....
Zfish   838 AVRHAEREMLEKHTEDITTQVEGAISRARSRWLQDLTSLPEYKSSLQTEKAEWERLQQQHVQEQV 902

  Fly   666 AKELK----------------------ELEHALEQSKNLQAEMQE---------KIELSNKQDEL 699
            :..:|                      .||...|:...|.||::.         |.||:..:|..
Zfish   903 SSAVKSAEERWQDTLRSKCSELEDGNRRLEELQEEVLTLSAELERSSQERDALVKAELAAARDAW 967

  Fly   700 ISDLKERAKQFEAYIRQQEEHKQQNKCTPSPKSNSVSPSDPSPKELTQNRIRLIEQRVRDEMAKL 764
            |.|.:|...:....::::.:||.|                           .::||.: ::..|.
Zfish   968 IRDKQEDMSRLRVQLQREHKHKLQ---------------------------AVLEQNL-EQTGKQ 1004

  Fly   765 FAAELKRFTNRLQK--SEERSQCLQREYQTVCAELQQRQTEVDLLKQTILAERENIDEILAGREE 827
            ...||:|.....::  |.|:...||.|.|.:..||.|...|.       |.|.|...|.....|.
Zfish  1005 RETELQRVIREKEQEWSGEQESRLQEERQKLLEELLQDLKEA-------LQEGEERRESPEDTET 1062

  Fly   828 KQKEMLQKCRQEL-QAKNQ-------RIAELLREVEEQH-ASIDSERQSMKA-------VMAQWE 876
            .:..:.:.|||.| |||.:       ::..:|:|.:|:| |.|...|:..:.       .:::.:
Zfish  1063 TRSRVWEICRQSLSQAKQEWEKSSEDKLRRVLKEAQERHEAEIAGLRKQSECGSPACAEALSKLQ 1127

  Fly   877 KQRQSVDQ------------VEHHWRQQLESLRSTHEEAMRSAQQRYQSA----KRTAHNYKLYA 925
            |:.|.:.:            |..| :..|:.::..||.|::..|||:..|    |:|::...|.:
Zfish  1128 KKNQDLQRHLEKACRQLQRSVREH-KNTLQRIKDEHEAALQKEQQRHLKALEELKQTSNAEALTS 1191

  Fly   926 ED-KEAHMKREYERIKHEYELSLAKIEATMNQHLERRSREK 965
            .. .:.:::...|.:|.:|..::.||:..|.::|: .|:|:
Zfish  1192 GSVGQQNLQAGLEEMKEQYMKAVEKIKGDMLRYLQ-ESKER 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asl	NP_649557.2	SMC_prok_B	<97..709	CDD:274008	165/742 (22%)
		DUF342	<428..503	CDD:302792	15/77 (19%)
		GluZincin	484..>629	CDD:301352	40/171 (23%)
cep152	XP_009296419.1	Smc	312..1218	CDD:224117	213/962 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KJ0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900