Protein Alignment SecS and SEPSECS

DIOPT Version :9

• Sequence 1: NP_649556.3
• Gene: SecS / 40681
• FlyBaseID: FBgn0037347
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: XP_016863766.1
• Gene: SEPSECS / 51091
• HGNCID: 30605
• Length: 586
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 221/553 - (39%)
• Similarity: 319/553 - (57%)
• Gaps: 85/553 - (15%)

  Fly     1 MNFEQVNIPEKLVPDNYLQLGLAAQRSKQRSFKELLEKR-------------------------- 39
            ||.|.....|:||...|::.|..|:||.:...:.||||.
Human     1 MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKSLALSPRLECSVTISAHCSLRLPGSRH 65

  Fly    40 -----------------------------------------------------------KLPKNG 45
                                                                       |.|:||
Human    66 SPASASRVAGTTGARHHTRLMFVFLVEMGFHHVGQADLKLLTSSDRPFLAFQSARITGGKCPENG 130

  Fly    46 WSDERIEELVHMLASLDSNNYPHKVGLGEREARIACKLVARRHYNFGHGIGRSGDLLEAQPKAAG 110
            |.:..:|..:|.||.:||||:....|:||||.|:|..|||||||.|.||||||||:...||||||
Human   131 WDESTLELFLHELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAG 195

  Fly   111 STLLARLTNALILDLIRGIGLPSCAGCFLVPMCTGMTLTLCLQSLRKRRPGARYVLWSRIDQKSC 175
            |:||.::||:|:||:|:..|:.:.|.||:|||.|||:||||..:||.:||.|:|::|.|||||||
Human   196 SSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSC 260

  Fly   176 FKAITATGLVPVVIPCLIKGESLNTNVDLFREKIKSLGVDSILCLYTTTSCFAPRNSDDIAEVSK 240
            ||::...|..||||..:::|:.|.|::.....|::.||.|.|||:::||||||||..|.:.|::.
Human   261 FKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAV 325

  Fly   241 LSKQWQIPHLVNNAYGLQAKEIVNQLECANRVGRIDYFVQSSDKNLLVPVGSAIVASFNESVLHD 305
            :...:.|||:||||||:|:.:.::.::...||||||.||||.|||.:||||.||:|.||:|.:.:
Human   326 ICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQE 390

  Fly   306 VASTYAGRASGSQSLDVLMTLLSLGRNGFRLLFDQRGENFNYLRENLRKFAEPRGEIVIDSRFNS 370
            ::..|.||||.|.|||||:||||||.||::.|..:|.|.|:||...::|.:|...|.::.:..|.
Human   391 ISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLHTPHNP 455

  Fly   371 ISLAITLATLAGDQMKSITKLGSMLHMRGVSGARVIVPGQNKTIDGHEFLDFGSHRSNLQVPYLT 435
            ||||:||.||...:.|::|:|||||..|.||||||:..|..:|:.|:.|..|.||.:|....||.
Human   456 ISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFRGFMSHTNNYPCAYLN 520

  Fly   436 VAAGIGITREEIDKFFDIFNKCWNQIFQTKNEK 468
            .|:.||:..:::|.|....::|...:.:.::::
Human   521 AASAIGMKMQDVDLFIKRLDRCLKAVRKERSKE 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecS	NP_649556.3	AAT_I	12..457	CDD:302748	216/529 (41%)
SEPSECS	XP_016863766.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158169
Domainoid	1	1.000	403	1.000	Domainoid score	I728
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15031
Inparanoid	1	1.050	447	1.000	Inparanoid score	I1637
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62354
OrthoDB	1	1.010	-	-		D258637at33208
OrthoFinder	1	1.000	-	-		FOG0005692
OrthoInspector	1	1.000	-	-		oto89698
orthoMCL	1	0.900	-	-		OOG6_104780
Panther	1	1.100	-	-	LDO	PTHR12944
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5548
SonicParanoid	1	1.000	-	-		X4683
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800