Protein Alignment SecS and HDC

DIOPT Version :9

• Sequence 1: NP_649556.3
• Gene: SecS / 40681
• FlyBaseID: FBgn0037347
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 110/550 - (20%)
• Similarity: 174/550 - (31%)
• Gaps: 205/550 - (37%)

  Fly    64 NNYPHKVGLG-----EREARIACKLVARRHYNFGHGIGRSGDLLE---AQPKAAGSTLLARLT-- 118
            :::|...|.|     ..|:.:...|.||::           .:||   ::|.|..|.|.|||.
Human   135 HHHPSSQGGGVLQSTVSESTLIALLAARKN-----------KILEMKTSEPDADESCLNARLVAY 188

  Fly   119 ----------NALILDLIRGIGLP-----SCAG------------CFLVP--MC-----TGMTLT 149
                      .|.::.|::...||     |..|            ..|||  :|     ||:...
Human   189 ASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAF 253

  Fly   150 LCLQSL----RKRRP-----------------------------GARYVLWSRIDQKSCFKAITA 181
            .||..|    :...|                             |||..||..||     .|...
Human   254 DCLSELGPISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHID-----AAYAG 313

  Fly   182 TG-LVPVVIPCLIKGESLNTNVDLFREKIKSLGVDSILCLYTTTSCFAPRNSDDIAEVSKLSKQW 245
            |. |.|.                 ||..:|  |::     |..:..|.|             .:|
Human   314 TAFLCPE-----------------FRGFLK--GIE-----YADSFTFNP-------------SKW 341

  Fly   246 QIPHL------VNNAYGLQAKEIVN------------------QLECANRVGRID-YFVQSS--D 283
            .:.|.      |.:.|.||....||                  |:..:.|...:. :||..|  .
Human   342 MMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGV 406

  Fly   284 KNLLVPV--GSAIVASFNESVLHD-----VASTYAG----RASGSQSL--DVLMTLLSLGRNGFR 335
            |||...|  |:.:...|...|.:|     .|..:.|    |..|...|  :||..:...||   .
Human   407 KNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGR---L 468

  Fly   336 LLFDQRGENFNYLRENLRKFAEPRGEIVIDSRFNSISLAITLATLAGDQMKSITKLGSMLHMRGV 400
            .|.....::...:|..:......|.:|:.|  :|.|..|.||........:...::|:::..  :
Human   469 FLIPATIQDKLIIRFTVTSQFTTRDDILRD--WNLIRDAATLILSQHCTSQPSPRVGNLISQ--I 529

  Fly   401 SGARVIVPGQN-KTIDGHEFLDFGSHRSNLQVPYLTVAAGIGITREE----IDKFFDIFNKCWNQ 460
            .|||....|.: :::.|... |....|..::.|.   ..|.|..:.|    ::...|..:.|:::
Human   530 RGARAWACGTSLQSVSGAGD-DPVQARKIIKQPQ---RVGAGPMKRENGLHLETLLDPVDDCFSE 590

  Fly   461 -------------IF-----QTKNEKIMSL 472
                         :|     |||.:.:.||
Human   591 EAPDATKHKLSSFLFSYLSVQTKKKTVRSL 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecS	NP_649556.3	AAT_I	12..457	CDD:302748	103/515 (20%)
HDC	XP_016877583.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900