Protein Alignment SecS and GAD2

DIOPT Version :10

• Sequence 1: NP_649556.3
• Gene: SecS / 40681
• FlyBaseID: FBgn0037347
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: NP_000809.1
• Gene: GAD2 / 2572
• HGNCID: 4093
• Length: 585
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 57/336 - (16%)
• Similarity: 124/336 - (36%)
• Gaps: 91/336 - (27%)

  Fly   162 ARYVLWSRIDQK------------------SCFKAITATGL---VPVVIPCLIKGESLNTNVDLF 205
            ||:.::..:.:|                  |..|...|.|:   ..::|.|..:|:.:.::::..
Human   254 ARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERR 318

  Fly   206 REKIKSLGVDSILCLYTT-TSCFAPRNSDDIAEVSKLSKQWQIPHLVNNAYG---LQAKEIVNQL 266
            ..:.|..|....|...|. |:.:..  .|.:..|:.:.|:::|...|:.|:|   |.:::...:|
Human   319 ILEAKQKGFVPFLVSATAGTTVYGA--FDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKL 381

  Fly   267 ECANRVGRIDYFVQSSDKNLLVPVGSAIVASFNESVLHDVASTYAG------------------- 312
            ....|...:.:   :..|.:.||:..:.:....|.::.:....:|.
Human   382 SGVERANSVTW---NPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKA 443

  Fly   313 ----------------RASGS--------QSLDVLMTLLSL--GRNGFRLLFDQRGENFN----Y 347
                            ||.|:        :.|::...|.::  .|.|:.::||.:.::.|    |
Human   444 LQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWY 508

  Fly   348 LRENLRKFAEPRGEIVIDSRFNSISLAITLATLA-GDQMKSITKLGSMLHMRGVSGARVIVPGQN 411
            :..:||...:....:   ||.:.::..|....:. |..|.|...||..     |:..|:::....
Human   509 IPPSLRTLEDNEERM---SRLSKVAPVIKARMMEYGTTMVSYQPLGDK-----VNFFRMVISNPA 565

  Fly   412 KTIDGHEFLDF 422
            .|   |:.:||
Human   566 AT---HQDIDF 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecS	NP_649556.3	AAT_I	12..457	CDD:450240	57/336 (17%)
GAD2	NP_000809.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		Pyridoxal_deC	138..509	CDD:395219	40/259 (15%)