Protein Alignment SecS and Sepsecs

DIOPT Version :10

• Sequence 1: NP_649556.3
• Gene: SecS / 40681
• FlyBaseID: FBgn0037347
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: NP_766078.1
• Gene: Sepsecs / 211006
• MGIID: 1098791
• Length: 504
• Species: Mus musculus
• Alignment Length: 459
• Identity: 224/459 - (48%)
• Similarity: 309/459 - (67%)
• Gaps: 0/459 - (0%)

  Fly     1 MNFEQVNIPEKLVPDNYLQLGLAAQRSKQRSFKELLEKRKLPKNGWSDERIEELVHMLASLDSNN 65
            ||.|.....|:.|...|::.|..|:|:.:...:.|||:.|.|::||.:..:|..:|.||.:||||
Mouse     1 MNPESFAAGERRVSPAYVRQGCEARRAHEHLIRLLLEQGKCPEDGWDESTLELFLHELAVMDSNN 65

  Fly    66 YPHKVGLGEREARIACKLVARRHYNFGHGIGRSGDLLEAQPKAAGSTLLARLTNALILDLIRGIG 130
            :....|:||||.|:|..|||||||.|.||||||||:...|||||||:||.::||:|:|::|:..|
Mouse    66 FLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLNVIKLAG 130

  Fly   131 LPSCAGCFLVPMCTGMTLTLCLQSLRKRRPGARYVLWSRIDQKSCFKAITATGLVPVVIPCLIKG 195
            :.|.|.||:|||.|||:||||..:||.:||.|:|::|.|||||||||::...|..||||..:::|
Mouse   131 VHSVASCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMVTAGFEPVVIENVLEG 195

  Fly   196 ESLNTNVDLFREKIKSLGVDSILCLYTTTSCFAPRNSDDIAEVSKLSKQWQIPHLVNNAYGLQAK 260
            :.|.|::.....||:.||.:.||||::||:|||||..|.:.|::.:...:.|||:||||||||:.
Mouse   196 DELRTDLKAVEAKIQELGPEHILCLHSTTACFAPRVPDRLEELAVICANYDIPHVVNNAYGLQSS 260

  Fly   261 EIVNQLECANRVGRIDYFVQSSDKNLLVPVGSAIVASFNESVLHDVASTYAGRASGSQSLDVLMT 325
            :.::.::...||||||.||||.|||.:||||.||:|.|||..:.|::..|.||||.|.|||||:|
Mouse   261 KCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNEPFIQDISKMYPGRASASPSLDVLIT 325

  Fly   326 LLSLGRNGFRLLFDQRGENFNYLRENLRKFAEPRGEIVIDSRFNSISLAITLATLAGDQMKSITK 390
            |||||.:|:|.|..:|.|.|.||...|:|.||...|.::.:..|.||||:||.|:.|...|::|:
Mouse   326 LLSLGCSGYRKLLKERKEMFVYLSTQLKKLAEAHNERLLQTPHNPISLAMTLKTIDGHHDKAVTQ 390

  Fly   391 LGSMLHMRGVSGARVIVPGQNKTIDGHEFLDFGSHRSNLQVPYLTVAAGIGITREEIDKFFDIFN 455
            |||||..|.|||||.:..|..:|:.||.|..|.||..|....||..||.||:..:::|.|....:
Mouse   391 LGSMLFTRQVSGARAVPLGNVQTVSGHTFRGFMSHADNYPCAYLNAAAAIGMKMQDVDLFIKRLD 455

  Fly   456 KCWN 459
            ||.|
Mouse   456 KCLN 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecS	NP_649556.3	AAT_I	12..457	CDD:450240	217/444 (49%)
Sepsecs	NP_766078.1	Tetramerization. /evidence=ECO:0000269|PubMed:18093968	1..44		14/42 (33%)
		selenium_SpcS	13..458	CDD:211833	218/444 (49%)
		Phosphate loop (P-loop). /evidence=ECO:0000269|PubMed:18093968	96..106		5/9 (56%)