DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kra and BZW1

DIOPT Version :9

Sequence 1:	NP_524238.1	Gene:	kra / 40680	FlyBaseID:	FBgn0250753	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001193997.1	Gene:	BZW1 / 9689	HGNCID:	18380	Length:	451	Species:	Homo sapiens

Alignment Length:	417	Identity:	217/417 - (52%)
Similarity:	314/417 - (75%)	Gaps:	2/417 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SQKTERPVLSGQRIKTRKRDEREKYDPTGFRDAVIAGLEKTEGDLEQISKYLDSAGNKLDYRRYG 66
            :||.::|.|||||.|||||||:|::|||.|:|.:|.||.:|..|||.::|:||::|.|||||||.
Human    35 NQKQQKPTLSGQRFKTRKRDEKERFDPTQFQDCIIQGLTETGTDLEAVAKFLDASGAKLDYRRYA 99

  Fly    67 EVLFDILIAGGLLVPGGSISQDGEKPRTSYCIFDAPESMESMRNHEQVFVKLIRRYKYLEKMFEE 131
            |.|||||:|||:|.|||:::.|  ..||..|:|.|.|.:|:|:...|||.|||||||||||.||:
Human   100 ETLFDILVAGGMLAPGGTLADD--MMRTDVCVFAAQEDLETMQAFAQVFNKLIRRYKYLEKGFED 162

  Fly   132 EMGKVLLFVKGFTPSERIKLARMTALWLVNGSVPPNVLLVLNNEHLIKDGIALEFLLELFQTFKQ 196
            |:.|:|||:|||:.|||.|||.:|.:.|.||::..::|..|.||:|:|:|::..|.::||:::..
Human   163 EVKKLLLFLKGFSESERNKLAMLTGVLLANGTLNASILNSLYNENLVKEGVSAAFAVKLFKSWIN 227

  Fly   197 EKGIAYLIQALKKGGLESKLMDFFPPNKRTEEYFKQVFLDKELNEIVKLHKAQASQEAKRELQQA 261
            ||.|..:..:|:|..::::||:.||.||::.|:|.:.|.:..|.|:.:..:.|.:..|::|||:.
Human   228 EKDINAVAASLRKVSMDNRLMELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKE 292

  Fly   262 LIDDINDEKPYNEITSDIKDFSQRTNIPDHEIIVIIWSTIMSLGEWNKKEELVTDQAVRHLKNYC 326
            |.:.::...|:.:|...:|:..::.|||:..:|.|:||::||..|||||||||.:||::|||.|.
Human   293 LQEQMSRGDPFKDIILYVKEEMKKNNIPEPVVIGIVWSSVMSTVEWNKKEELVAEQAIKHLKQYS 357

  Fly   327 PLLQAFASTDRSELALILKVQEFCYENMNFMKAFQKIILLFYKTEVLSEEIILRWYKEGHSNKGK 391
            |||.||.:..:|||.|:||:||:||:|::||||||||::||||.||||||.||:|||:.|..|||
Human   358 PLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAHVAKGK 422

  Fly   392 MHFLEQMRKFVEWLQSAEEESESEDEQ 418
            ..|||||:||||||::||||||||.|:
Human   423 SVFLEQMKKFVEWLKNAEEESESEAEE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kra	NP_524238.1	W2_eIF5C_like	218..406	CDD:211398	95/187 (51%)
BZW1	NP_001193997.1	W2_eIF5C_like	249..438	CDD:211398	96/188 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150898
Domainoid	1	1.000	327	1.000	Domainoid score	I1172
eggNOG	1	0.900	-	-		E1_KOG2297
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41651
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1627
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57232
OrthoDB	1	1.010	-	-		D383363at33208
OrthoFinder	1	1.000	-	-		FOG0002614
OrthoInspector	1	1.000	-	-		otm40652
orthoMCL	1	0.900	-	-		OOG6_103948
Panther	1	1.100	-	-	O	PTHR14208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4560
SonicParanoid	1	1.000	-	-		X1719
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800