DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kra and bzw1a

DIOPT Version :9

Sequence 1:	NP_524238.1	Gene:	kra / 40680	FlyBaseID:	FBgn0250753	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_956002.1	Gene:	bzw1a / 325226	ZFINID:	ZDB-GENE-030131-3951	Length:	419	Species:	Danio rerio

Alignment Length:	417	Identity:	218/417 - (52%)
Similarity:	319/417 - (76%)	Gaps:	2/417 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SQKTERPVLSGQRIKTRKRDEREKYDPTGFRDAVIAGLEKTEGDLEQISKYLDSAGNKLDYRRYG 66
            :||.::|.|:|||.|||||||:|::||:.|:::::.||.:|..|||.::|:||::|.|||||||.
Zfish     3 NQKQQKPTLTGQRFKTRKRDEKERFDPSQFQESIVQGLNQTGTDLEAVAKFLDASGAKLDYRRYA 67

  Fly    67 EVLFDILIAGGLLVPGGSISQDGEKPRTSYCIFDAPESMESMRNHEQVFVKLIRRYKYLEKMFEE 131
            |.|||||:|||:|.|||::|.|  ..||.||:|.|.|.:|:|:.:.|||.|||||||||||.|||
Zfish    68 ETLFDILVAGGMLAPGGTLSDD--LTRTEYCLFTASEDLETMQAYAQVFNKLIRRYKYLEKGFEE 130

  Fly   132 EMGKVLLFVKGFTPSERIKLARMTALWLVNGSVPPNVLLVLNNEHLIKDGIALEFLLELFQTFKQ 196
            |:.|:|||:||||.|||.|||.:|.:.|.||::..::|..|.||:|:|:|::..|.::||:::..
Zfish   131 EIKKLLLFLKGFTESERNKLAMLTGILLANGNISASILNSLFNENLVKEGVSAAFAVKLFKSWIN 195

  Fly   197 EKGIAYLIQALKKGGLESKLMDFFPPNKRTEEYFKQVFLDKELNEIVKLHKAQASQEAKRELQQA 261
            ||.|..:..:|:|.|::::||:.||.|||:.|:|.:.|.|..|.|:....:.|.|..|::|||:.
Zfish   196 EKDINSVAASLRKVGMDNRLMELFPANKRSCEHFSKYFTDAGLKELSDFARNQQSIGARKELQKE 260

  Fly   262 LIDDINDEKPYNEITSDIKDFSQRTNIPDHEIIVIIWSTIMSLGEWNKKEELVTDQAVRHLKNYC 326
            |.:.::..:...:|.:.:::..::|:|.:..:|.|:|:::||..||||||||||:||::|||.|.
Zfish   261 LQEQMSRGETLKDIIAYVREEMKKTSISEQTMIGIVWTSVMSSVEWNKKEELVTEQAIKHLKQYS 325

  Fly   327 PLLQAFASTDRSELALILKVQEFCYENMNFMKAFQKIILLFYKTEVLSEEIILRWYKEGHSNKGK 391
            |||:||.|...|||.|:||:||:||:|::||||||||::|.||.:|||||:||:||.|||..|||
Zfish   326 PLLKAFTSQGLSELTLLLKIQEYCYDNIHFMKAFQKIVVLLYKADVLSEEVILKWYTEGHVAKGK 390

  Fly   392 MHFLEQMRKFVEWLQSAEEESESEDEQ 418
            ..|||||:||||||::||||||||:|:
Zfish   391 SVFLEQMKKFVEWLKNAEEESESEEEE 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kra	NP_524238.1	W2_eIF5C_like	218..406	CDD:211398	95/187 (51%)
bzw1a	NP_956002.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		15/25 (60%)
bzw1a	NP_956002.1	W2_eIF5C_like	217..407	CDD:211398	96/189 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585507
Domainoid	1	1.000	334	1.000	Domainoid score	I1103
eggNOG	1	0.900	-	-		E1_KOG2297
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41651
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1560
OMA	1	1.010	-	-		QHG57232
OrthoDB	1	1.010	-	-		D383363at33208
OrthoFinder	1	1.000	-	-		FOG0002614
OrthoInspector	1	1.000	-	-		otm26099
orthoMCL	1	0.900	-	-		OOG6_103948
Panther	1	1.100	-	-	O	PTHR14208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4560
SonicParanoid	1	1.000	-	-		X1719
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800