DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha26 and ATP6V1E1

DIOPT Version :9

Sequence 1:	NP_001287182.1	Gene:	Vha26 / 40679	FlyBaseID:	FBgn0283535	Length:	226	Species:	Drosophila melanogaster
Sequence 2:	NP_001687.1	Gene:	ATP6V1E1 / 529	HGNCID:	857	Length:	226	Species:	Homo sapiens

Alignment Length:	226	Identity:	143/226 - (63%)
Similarity:	185/226 - (81%)	Gaps:	0/226 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQQQRLKIMEYYEKKEKQVE 65
            |||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||:|
Human     1 MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIE 65

  Fly    66 LQKKIQSSNMLNQARLKVLKVREDHVSSVLDDARKRLGEVTKNQSEYETVLTKLIVQGLFQIMEP 130
            .|||||.||::||||||||:.|:|.::.:|::|::||.:|.|:.:.|:.:|..|::|||:|::||
Human    66 QQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEP 130

  Fly   131 KVILRCREVDVPLVRNVLPAAVEQYKAQINQNVELFIDEKDFLSADTCGGVELLALNGRIKVPNT 195
            ::|:|||:.|.|||:..:..|:..||.....:|::.||::.:|..|..||||:...:.:|||.||
Human   131 RMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNT 195

  Fly   196 LESRLDLISQQLVPEIRNALFGRNVNRKFTD 226
            ||||||||:||::||:|.||||.|.||||.|
Human   196 LESRLDLIAQQMMPEVRGALFGANANRKFLD 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha26	NP_001287182.1	NtpE	9..217	CDD:224308	127/207 (61%)
Vha26	NP_001287182.1	vATP-synt_E	18..216	CDD:280215	117/197 (59%)
ATP6V1E1	NP_001687.1	vATP-synt_E	18..216	CDD:396537	117/197 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148161
Domainoid	1	1.000	245	1.000	Domainoid score	I2185
eggNOG	1	0.900	-	-		E1_COG1390
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1282
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2791
Isobase	1	0.950	-	0	Normalized mean entropy	S881
OMA	1	1.010	-	-		QHG53684
OrthoDB	1	1.010	-	-		D1489718at2759
OrthoFinder	1	1.000	-	-		FOG0002151
OrthoInspector	1	1.000	-	-		otm41976
orthoMCL	1	0.900	-	-		OOG6_101237
Panther	1	1.100	-	-	LDO	PTHR45715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1632
SonicParanoid	1	1.000	-	-		X1613
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750