DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment noi and sf3a3

DIOPT Version :9

Sequence 1:	NP_477114.1	Gene:	noi / 40678	FlyBaseID:	FBgn0014366	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001017118.1	Gene:	sf3a3 / 549872	XenbaseID:	XB-GENE-947674	Length:	501	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	335/510 - (65%)
Similarity:	412/510 - (80%)	Gaps:	16/510 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METLLEQQRRLHEERERLVKLMVDEHATKKPGEKERIHSEHRLKYLMELHHNSTSQLRDLYEDKD 65
            |||:||||||..||:|||:.:|..|..:|||..:|:|:|:||.:.:::.:...:|.|||||||||
Frog     1 METILEQQRRYQEEKERLMDVMSKEMMSKKPTLREQINSDHRARAMLDQYMEVSSNLRDLYEDKD 65

  Fly    66 NERKAEIAALSGPNEFNEFYARLKQIKQFYKSHPAEVSVPLSVEFDEMIRVYNNP-DDMSALVEF 129
            ..||.|:.|:||||||.|||.|||.||:|::.||.|:.||:||||||:::...|| ::...||||
Frog    66 GLRKEELTAISGPNEFGEFYNRLKLIKEFHRKHPNEICVPMSVEFDELLKTRENPSEEAQNLVEF 130

  Fly   130 TDEEGGGRYLDLNECYELYLNLRSVEKLDYITYLMSFDHVFDIPRERKNREYRIYIETLNDYLHH 194
            |||||.|||:||::||..|:||:|.|||||||||.:||.:||||:||||.||:.|:|.|.:||..
Frog   131 TDEEGYGRYMDLHDCYLKYINLKSSEKLDYITYLATFDQLFDIPKERKNAEYKRYLEVLLEYLQD 195

  Fly   195 FILRIQPLLDLEGELL-KVELDFQRQWLMGTFPGFSIKETESALANTGAHLDLSAFSSWEELASL 258
            :..|::||.| :.||. |::::|:::|..|.|||:. |||.|||.:.||||||||||||||||||
Frog   196 YTDRVKPLQD-QNELFGKIQIEFEKKWEAGAFPGWP-KETSSALTHAGAHLDLSAFSSWEELASL 258

  Fly   259 GLDRLKSALVALGLKCGGTLEERAQRLFSTKGKS--TLDPALMAKKPSAKTASAQSREHERHKEI 321
            |||||||||:||||||||||||||||||||||||  :|||:|.||.|.||   ...|:.|::|:|
Frog   259 GLDRLKSALMALGLKCGGTLEERAQRLFSTKGKSLESLDPSLFAKNPKAK---GTRRDTEKNKDI 320

  Fly   322 AQLEALLYKYADLLSEQRAATKENVQRKQARTGGERDDSD---VEASESDNEDDPDADDVPYNPK 383
            |.|||.:|:|.::|.|||..|.|||||||||||.||::.:   :..||||:||    :::.||||
Frog   321 AFLEAQVYEYVEILGEQRHLTHENVQRKQARTGEEREEEEEEQISESESDDED----NEIIYNPK 381

  Fly   384 NLPLGWDGKPIPYWLYKLHGLNISYNCEICGNFTYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHF 448
            |||||||||||||||||||||||:|||||||||||:|||||||||||||||||||||||||||||
Frog   382 NLPLGWDGKPIPYWLYKLHGLNINYNCEICGNFTYRGPKAFQRHFAEWRHAHGMRCLGIPNTAHF 446

  Fly   449 ANVTQIEDAITLWEKLKSQKQSERWVADQEEEFEDSLGNVVNRKTFEDLKRQGLL 503
            |||||||||::||.|||.||.||||..|.|||:|||.|||||:||:|||||||||
Frog   447 ANVTQIEDAVSLWSKLKHQKASERWQPDTEEEYEDSSGNVVNKKTYEDLKRQGLL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
noi	NP_477114.1	PRP9	2..503	CDD:227515	332/507 (65%)
		SF3a60_bindingd	74..99	CDD:288924	16/24 (67%)
		SF3A3	128..203	CDD:293442	46/74 (62%)
		Telomere_Sde2_2	244..301	CDD:290036	52/58 (90%)
		DUF3449	324..500	CDD:288759	134/178 (75%)
sf3a3	NP_001017118.1	PRP9	2..501	CDD:227515	332/507 (65%)
sf3a3	NP_001017118.1	DUF3449	323..500	CDD:371805	136/180 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1460
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4949
Inparanoid	1	1.050	678	1.000	Inparanoid score	I720
OMA	1	1.010	-	-		QHG54569
OrthoDB	1	1.010	-	-		D215654at33208
OrthoFinder	1	1.000	-	-		FOG0005236
OrthoInspector	1	1.000	-	-		oto103850
Panther	1	1.100	-	-	LDO	PTHR12786
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1285
SonicParanoid	1	1.000	-	-		X3755
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110