DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment noi and sf3a3

DIOPT Version :9

Sequence 1:	NP_477114.1	Gene:	noi / 40678	FlyBaseID:	FBgn0014366	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001004289.1	Gene:	sf3a3 / 446168	ZFINID:	ZDB-GENE-040908-1	Length:	501	Species:	Danio rerio

Alignment Length:	508	Identity:	330/508 - (64%)
Similarity:	410/508 - (80%)	Gaps:	12/508 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METLLEQQRRLHEERERLVKLMVDEHATKKPGEKERIHSEHRLKYLMELHHNSTSQLRDLYEDKD 65
            |||:||||||.|||:|||:.....|..|||...:::|:|:||::.:::.:...::.|||||||||
Zfish     1 METILEQQRRYHEEKERLMDAKTKEMLTKKTTLRDQINSDHRVRAMLDRYMEVSANLRDLYEDKD 65

  Fly    66 NERKAEIAALSGPNEFNEFYARLKQIKQFYKSHPAEVSVPLSVEFDEMIRVYNNP-DDMSALVEF 129
            ..||.|:.|:||||||.|||.|||.||:|::.||.|:.||:||||:|:::..:|| ::...||||
Zfish    66 GMRKDELNAISGPNEFAEFYNRLKLIKEFHRKHPNEICVPMSVEFEELMKAKDNPSEEAQNLVEF 130

  Fly   130 TDEEGGGRYLDLNECYELYLNLRSVEKLDYITYLMSFDHVFDIPRERKNREYRIYIETLNDYLHH 194
            |||||.||||||::||..|:||:.||||:|:|||.:||.:|||.::|||.||:.|:|.|.:||..
Zfish   131 TDEEGYGRYLDLHDCYLKYINLKGVEKLEYVTYLSTFDQLFDISKDRKNAEYKKYLEMLLEYLQE 195

  Fly   195 FILRIQPLLDLEGELL-KVELDFQRQWLMGTFPGFSIKETESALANTGAHLDLSAFSSWEELASL 258
            :..|::|||| :.||. |:..:|:::|..|.|||:. |||.|||.:.||||||||||||||||||
Zfish   196 YTDRVKPLLD-QNELYGKILAEFEKKWETGMFPGWP-KETSSALTHAGAHLDLSAFSSWEELASL 258

  Fly   259 GLDRLKSALVALGLKCGGTLEERAQRLFSTKGKS--TLDPALMAKKPSAKTASAQSREHERHKEI 321
            |||||||||:||||||||||||||||||||||||  :|||:|.||.|.||   ...::.||:||.
Zfish   259 GLDRLKSALMALGLKCGGTLEERAQRLFSTKGKSLESLDPSLFAKNPKAK---GPKKDSERNKES 320

  Fly   322 AQLEALLYKYADLLSEQRAATKENVQRKQARTGGERDDSDVE-ASESDNEDDPDADDVPYNPKNL 385
            |.|||.:|:|.::|.|||..:.|||||||||||.|||:.|.| .|||::||:.  :::.||||||
Zfish   321 AFLEAQIYEYVEILGEQRQLSHENVQRKQARTGEERDEEDEEQPSESESEDED--NEIIYNPKNL 383

  Fly   386 PLGWDGKPIPYWLYKLHGLNISYNCEICGNFTYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHFAN 450
            |||||||||||||||||||||:||||||||:||:|||||||||||||||||||||||||||||||
Zfish   384 PLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEWRHAHGMRCLGIPNTAHFAN 448

  Fly   451 VTQIEDAITLWEKLKSQKQSERWVADQEEEFEDSLGNVVNRKTFEDLKRQGLL 503
            |||||||::||.||||||..|||..|.|||:|||.|||||:||:|||||||||
Zfish   449 VTQIEDAVSLWSKLKSQKALERWQPDTEEEYEDSSGNVVNKKTYEDLKRQGLL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
noi	NP_477114.1	PRP9	2..503	CDD:227515	327/505 (65%)
		SF3a60_bindingd	74..99	CDD:288924	16/24 (67%)
		SF3A3	128..203	CDD:293442	43/74 (58%)
		Telomere_Sde2_2	244..301	CDD:290036	52/58 (90%)
		DUF3449	324..500	CDD:288759	134/176 (76%)
sf3a3	NP_001004289.1	PRP9	2..501	CDD:227515	327/505 (65%)
		SF3a60_bindingd	74..100	CDD:288924	17/25 (68%)
		SF3A3	129..204	CDD:293442	43/74 (58%)
		Telomere_Sde2_2	244..303	CDD:290036	52/58 (90%)
		DUF3449	323..498	CDD:288759	134/176 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576355
Domainoid	1	1.000	298	1.000	Domainoid score	I1424
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4949
Inparanoid	1	1.050	665	1.000	Inparanoid score	I730
OMA	1	1.010	-	-		QHG54569
OrthoDB	1	1.010	-	-		D215654at33208
OrthoFinder	1	1.000	-	-		FOG0005236
OrthoInspector	1	1.000	-	-		oto38840
orthoMCL	1	0.900	-	-		OOG6_102364
Panther	1	1.100	-	-	LDO	PTHR12786
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3755
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910