DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment noi and sap61

DIOPT Version :9

Sequence 1:	NP_477114.1	Gene:	noi / 40678	FlyBaseID:	FBgn0014366	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_595337.1	Gene:	sap61 / 2540932	PomBaseID:	SPBC36.09	Length:	492	Species:	Schizosaccharomyces pombe

Alignment Length:	537	Identity:	178/537 - (33%)
Similarity:	268/537 - (49%)	Gaps:	82/537 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ETLLEQQRRLHEERERLVKLMVDEHATKKPGEKERIHSEHRLKYLMELHHNSTSQLRDLYEDKDN 66
            |::||.:|..|||.|||.:.:||.........:||:..||:....:.....::.:|...:|..|.
pombe     3 ESVLETERYAHEELERLQQAIVDRQVANPKAPRERLRLEHQSAQFLNQFRETSKKLLVSHESSDR 67

  Fly    67 ERKAEIAALSGPNEFNEFYARLKQIKQFYKSHPAEVSVPLSVEFDEMIRVY----NNP--DDMSA 125
            .:..|:|.::..::..|||..|.:|::|:|.:|..       :.:::.::|    :.|  |::..
pombe    68 LKDQEVARINADDDLTEFYKSLGEIQEFHKKYPDH-------KVEDLSQLYSIKPSQPGIDEIDT 125

  Fly   126 LVEFTDEEGGGRYLDLNECYELYLNLRSVEKLDYITYLMSFDHVFDIPRERKNREYRIYIETLND 190
            |  |..||..||::|||||||.|:||.:|:.:.|:.||.:.:....||:..||:.|..||..|.:
pombe   126 L--FRGEEMYGRFMDLNECYEEYINLSNVQHISYLEYLKNLEDFDQIPKPEKNQTYINYITHLYE 188

  Fly   191 YLHHFILRIQPLLDLEGELLKVELDFQRQWLMGTFPGFSIKETESALANTGAHLDLSAFSSWEEL 255
            ||..|..|..||.:|:..:...:.:|...|..| .||:                    :|...|.
pombe   189 YLVSFYRRTHPLSNLDKIIAVFDTEFDAAWEAG-LPGW--------------------YSHNAEA 232

  Fly   256 ASLGLDRLKSALVALGLKCGGTLEERAQRLFSTKGKSTLDPA-------------LMAKKPSAKT 307
            ...|.|..::      ..|     |..|:.|   ||.|:..|             :.:..||  |
pombe   233 EKDGKDSTEA------FYC-----EVCQKFF---GKITVFEAHKKSKAHNKAVKRMQSSSPS--T 281

  Fly   308 ASAQSREHERHKEIAQLEALLYKYADLLSEQRAATKENVQRKQARTGGERDDSDVEASE------ 366
            .|..:.:.:..|.||::|.|:.|...||.:.|..|:|||.|:|..|..|| .::|||:|
pombe   282 TSNTNEKQKGPKAIARIEFLIKKLTSLLDDVRKDTRENVVRRQTLTAAER-LAEVEAAEREAFEQ 345

  Fly   367 ----------SDNEDDPDADDVPYNPKNLPLGWDGKPIPYWLYKLHGLNISYNCEICGNFTYKGP 421
                      .|.|.|.|.::..|||..|||||||||||:||:|||||...:.||||||:.|.|.
pombe   346 STPSVSVEGNQDEESDQDDEEKIYNPLKLPLGWDGKPIPFWLWKLHGLGKEFPCEICGNYVYMGR 410

  Fly   422 KAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAITLWEKLKSQKQSERWVADQEEEFEDSLG 486
            |||.:||.|.||.:|::||||..:..|..:|.|::|:.||:|.|...:..........|.||..|
pombe   411 KAFDKHFTEQRHIYGLKCLGISPSPLFNQITSIDEALQLWQKYKVDSKKRETTMASLNEMEDDEG 475

  Fly   487 NVVNRKTFEDLKRQGLL 503
            ||::.|.:.|||.||||
pombe   476 NVMSEKVYNDLKAQGLL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
noi	NP_477114.1	PRP9	2..503	CDD:227515	176/535 (33%)
		SF3a60_bindingd	74..99	CDD:288924	7/24 (29%)
		SF3A3	128..203	CDD:293442	32/74 (43%)
		Telomere_Sde2_2	244..301	CDD:290036	12/69 (17%)
		DUF3449	324..500	CDD:288759	83/191 (43%)
sap61	NP_595337.1	PRP9	3..492	CDD:227515	176/535 (33%)
		SF3a60_bindingd	75..101	CDD:288924	7/25 (28%)
		SF3A3	126..200	CDD:293442	32/75 (43%)
		ZnF_U1	240..274	CDD:197732	8/47 (17%)
		DUF3449	299..489	CDD:288759	83/190 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	171	1.000	Domainoid score	I889
eggNOG	1	0.900	-	-		E1_COG5188
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	284	1.000	Inparanoid score	I651
OMA	1	1.010	-	-		QHG54569
OrthoFinder	1	1.000	-	-		FOG0005236
OrthoInspector	1	1.000	-	-		oto101283
orthoMCL	1	0.900	-	-		OOG6_102364
Panther	1	1.100	-	-	LDO	PTHR12786
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1285
SonicParanoid	1	1.000	-	-		X3755
TreeFam	1	0.960	-	-
	13	12.860