DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment noi and SF3A3

DIOPT Version :9

Sequence 1:	NP_477114.1	Gene:	noi / 40678	FlyBaseID:	FBgn0014366	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_006793.1	Gene:	SF3A3 / 10946	HGNCID:	10767	Length:	501	Species:	Homo sapiens

Alignment Length:	508	Identity:	332/508 - (65%)
Similarity:	410/508 - (80%)	Gaps:	12/508 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METLLEQQRRLHEERERLVKLMVDEHATKKPGEKERIHSEHRLKYLMELHHNSTSQLRDLYEDKD 65
            |||:||||||.|||:|||:.:|..|..|||...:::|:|:||.:.:.:.:...:..|||||:|||
Human     1 METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDLYDDKD 65

  Fly    66 NERKAEIAALSGPNEFNEFYARLKQIKQFYKSHPAEVSVPLSVEFDEMIRVYNNP-DDMSALVEF 129
            ..||.|:.|:||||||.|||.||||||:|::.||.|:.||:||||:|:::...|| ::...||||
Human    66 GLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENPSEEAQNLVEF 130

  Fly   130 TDEEGGGRYLDLNECYELYLNLRSVEKLDYITYLMSFDHVFDIPRERKNREYRIYIETLNDYLHH 194
            |||||.||||||::||..|:||::.|||||||||..||.:||||:||||.||:.|:|.|.:||..
Human   131 TDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNAEYKRYLEMLLEYLQD 195

  Fly   195 FILRIQPLLDLEGELL-KVELDFQRQWLMGTFPGFSIKETESALANTGAHLDLSAFSSWEELASL 258
            :..|::||.| :.||. |::.:|:::|..|||||:. |||.|||.:.||||||||||||||||||
Human   196 YTDRVKPLQD-QNELFGKIQAEFEKKWENGTFPGWP-KETSSALTHAGAHLDLSAFSSWEELASL 258

  Fly   259 GLDRLKSALVALGLKCGGTLEERAQRLFSTKGKS--TLDPALMAKKPSAKTASAQSREHERHKEI 321
            |||||||||:||||||||||||||||||||||||  :||.:|.||.|.:|   ...|:.||:|:|
Human   259 GLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSLFAKNPKSK---GTKRDTERNKDI 320

  Fly   322 AQLEALLYKYADLLSEQRAATKENVQRKQARTGGERDDSDVE-ASESDNEDDPDADDVPYNPKNL 385
            |.|||.:|:|.::|.|||..|.|||||||||||.||::.:.| .|||::||  :.:::.||||||
Human   321 AFLEAQIYEYVEILGEQRHLTHENVQRKQARTGEEREEEEEEQISESESED--EENEIIYNPKNL 383

  Fly   386 PLGWDGKPIPYWLYKLHGLNISYNCEICGNFTYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHFAN 450
            |||||||||||||||||||||:||||||||:||:|||||||||||||||||||||||||||||||
Human   384 PLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEWRHAHGMRCLGIPNTAHFAN 448

  Fly   451 VTQIEDAITLWEKLKSQKQSERWVADQEEEFEDSLGNVVNRKTFEDLKRQGLL 503
            |||||||::||.|||.||.||||..|.|||:|||.|||||:||:|||||||||
Human   449 VTQIEDAVSLWAKLKLQKASERWQPDTEEEYEDSSGNVVNKKTYEDLKRQGLL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
noi	NP_477114.1	PRP9	2..503	CDD:227515	329/505 (65%)
		SF3a60_bindingd	74..99	CDD:288924	17/24 (71%)
		SF3A3	128..203	CDD:293442	46/74 (62%)
		Telomere_Sde2_2	244..301	CDD:290036	51/58 (88%)
		DUF3449	324..500	CDD:288759	133/176 (76%)
SF3A3	NP_006793.1	PRP9	2..501	CDD:227515	329/505 (65%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:21349847	175..179		2/3 (67%)
		DUF3449	323..500	CDD:403216	135/178 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..374		19/32 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143483
Domainoid	1	1.000	294	1.000	Domainoid score	I1500
eggNOG	1	0.900	-	-		E1_COG5188
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4949
Inparanoid	1	1.050	669	1.000	Inparanoid score	I746
Isobase	1	0.950	-	0	Normalized mean entropy	S1285
OMA	1	1.010	-	-		QHG54569
OrthoDB	1	1.010	-	-		D215654at33208
OrthoFinder	1	1.000	-	-		FOG0005236
OrthoInspector	1	1.000	-	-		oto90041
orthoMCL	1	0.900	-	-		OOG6_102364
Panther	1	1.100	-	-	LDO	PTHR12786
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1285
SonicParanoid	1	1.000	-	-		X3755
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750