DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2926 and Scaf11

DIOPT Version :9

Sequence 1:	NP_649554.1	Gene:	CG2926 / 40676	FlyBaseID:	FBgn0037344	Length:	2296	Species:	Drosophila melanogaster
Sequence 2:	XP_006521493.1	Gene:	Scaf11 / 72193	MGIID:	1919443	Length:	1472	Species:	Mus musculus

Alignment Length:	2271	Identity:	437/2271 - (19%)
Similarity:	668/2271 - (29%)	Gaps:	916/2271 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 KRKKV-------ESSDEEEPERTPNAVGRIQPMPADPDDGFSSDISSNDLLEKCPICLLTFRQQE 166
            |:|.|       :..|:.|.|...|.        ||......|:      .::|||||.....:|
Mouse     2 KKKSVYNQNVGDQECDDMEGEENSNT--------ADASGLLYSE------ADRCPICLSCLLGKE 52

  Fly   167 IGTPATCEHIFCAACIDAWSRNVQTCPIDRIEFDRIIVRDSY---ASRRVVREVRLDLSKSN--- 225
            :|.|.:|.|:||.|||..|:..:.:|||||..|..:....::   |..:|.|.:|....|.|
Mouse    53 VGFPESCNHVFCMACILKWAEILASCPIDRKPFQAVFELSAFEGCAKIQVKRRLRETEDKENQRS 117

  Fly   226 --TELVVDDEADTAALSEEEVTNCEICESPDREDVMLLCDSCNQGYHMDCLDPPLYEIPAGSWYC 288
              .:|...:.:.........:          |||  |||
Mouse   118 FKKQLFYHESSKGNKRKRNTI----------RED--LLC-------------------------- 144

  Fly   289 DNCIDSDDEDDNEQLELADDLDQLYEDIRGM--GLPETRLRVREVQEP----------------- 334
                           |.:|.|..||.:|...  |.....::..:||..
Mouse   145 ---------------ERSDGLKVLYRNISNKMDGKKNATVKTNKVQRSNQCTDSCIRNEMSSVFS 194

  Fly   335 -------PRILRTRQNERIR----AAVLRRTR-------------------SGATSAEDSTLTRT 369
                   ||..|....|.|.    :|::|:.|                   |...|.|.:.|:..
Mouse   195 CGSHSWGPRTHRASCTESIEVNEISALIRQKRQELELSWFPNTLPGNGRVGSVPWSVETAFLSLA 259

  Fly   370 RTRTTTTTTTTTTTTRRTTTSTKKRPVQRRRRRRTRYRTYVVEYDLNNFDEKFALKTSKKVIRRR 434
            .:....|....:||:              .....|.::.|.:.:.....::|....||     ..
Mouse   260 SSGLPRTVFPASTTS--------------LEHFGTSHKGYALAHTQGGGEKKQTSGTS-----NT 305

  Fly   435 RRRRRRGVATASSEGPGRRLSASKRLAEQMGVKSEGFQSSHLSGGTASSFSLFGNANDLEYFSDS 499
            |..||:..|||    |.||.:.:.| ||.:.      ||........|.....||:|.....|
Mouse   306 RGSRRKPAATA----PTRRSTRNTR-AETVS------QSQKSPVSNYSECDAPGNSNSSVSIS-- 357

  Fly   500 EPDAVSQISSAGLGSTAVQTSVRIGSIGAPRIRKALLQGKARIAAPPTAPTSAPAADILSSILDL 564
             |.|.|:..:.   ....:.|||.|.      :..||:.|.|.:.||...:|:.:.:
Mouse   358 -PPAESEKQTR---QAPKRKSVRRGR------KPPLLKKKLRRSVPPAEKSSSDSVE-------- 404

  Fly   565 QDRWHDASRNLGEVHIRADGTLNIPQRPAPTATEAPLPKAGTSKTEKHLTQAPLYQQGGGGPNYN 629
                        |..:.:| |..:.::...:..|:....:..:..|.||......:|
Mouse   405 ------------EETVDSD-TPPVLEKEQQSCVESSSICSVQTDEENHLHLESCSEQ-------- 448

  Fly   630 RGGGAGSSDSYNNRYSGNTSYRGGGGGGAGGSSGGSGVPSSSGEASSRHLTGEGDGQGGGGFGNQ 694
                     :..|..:.|...                      |..:..|..|...|...|.
Mouse   449 ---------TEENEQANNHEI----------------------EEQTESLNSESCTQDPPGL--- 479

  Fly   695 NFSSSGSNNNTNMSSFIPFH-LRFNTPTRQQQPRQQNVLPANQPTPPFPGSAPPPAPVASSSNNF 758
                .|.:.......|...| :..:|..|.:..                         |......
Mouse   480 ----VGEDTGIEAKEFCADHDISPDTSLRGRDS-------------------------AEHQEQL 515

  Fly   759 SGQTPMFAAPLNHHPAPVMGMPVVLSIPPPPMPPASLPWNSPLFKITPLQQAPAKSNDGNQNDDV 823
            ||.:......|....:|..|.|..     ||......|.:|||.:::. ...|..|::
Mouse   516 SGSSESEVQALVCTESPPEGSPTC-----PPSDIEHQPVSSPLGEVSD-NTTPVVSDE------- 567

  Fly   824 DNCPNFSIYSQESQAVANASAMPSGVPHGPADASDK--------DDDDMNEDLVQLDDDDEDTDI 880
                    .::||..|.:            .|.:|:        :..|:|:..|.::...|...:
Mouse   568 --------RAEESLTVES------------TDLNDERTGESLTVESTDLNDSAVNIEAFVESPKM 612

  Fly   881 PLPLGPEPEPVPEKVPKSSDDDLYEPEN-PTEEPEEPEMFEESCDAVPTEKSESSDHEPSNSNVQ 944
            ....|...:.:......|||.:|  ||: .||..|    ...:|:.:.||.:|..   |:..::|
Mouse   613 ESCEGETAQGLDRHCVPSSDSEL--PEHIQTENTE----IIPACEHIQTENTEII---PACEHIQ 668

  Fly   945 AAAPEENDAEEARTRSTP--SPLVKEDRAADRDRAKGVLELYDDSDWEELDIDKPKEFEKALLTE 1007
            .    ||      |...|  ..|..|:..|.:|....:|:       ..||..:..:|    |.|
Mouse   669 T----EN------TEIIPVCGTLENENSDAVQDCEDNLLK-------HNLDNSQSDKF----LEE 712

  Fly  1008 TEAQVSPKRAPSKRPPSKKDTSLERDVNESGSEHEQDRSYTPCLDEKNLAEEEEAGTTHQNNVST 1072
            |...:......::.|..:.|.| |:..:|..:|.......:.|.|: |.:|.|.:..|....:|.
Mouse   713 TTESLVEHPIHAELPHKEVDQS-EKHFSEDNNESVPMECDSFCSDQ-NESEVESSANTDSKQLSE 775

  Fly  1073 SPKTRSSKVSGDEDEPEKAVGTDIQSEDELNNENESPRRSRSR-----GTANNKKD----KSKSR 1128
            :....||:.....|...:.|.|..|..:.|.::...||..|||     .|.:..||    |.:::
Mouse   776 NSVPHSSEDKLSSDPAVEKVETVAQPAESLVDKAPKPRTRRSRFHSPSTTWSPNKDAAQEKRRAQ 840

  Fly  1129 SKRNKGETFKKVGKRQKDRNYRGDKSEPDRSPRPDSRSLTPKMRSKSPRVSKSISRSRSGSRSRC 1193
            |...|.||..              :|:..:||.|...|...:.:|:|....|.::|.|..|||..
Mouse   841 SPSPKRETVV--------------ESQSSQSPSPKRESARGRRKSRSLSPKKDVARERRQSRSPK 891

  Fly  1194 KSKSFSRSRSRSPSRSRNRRRRNSRSKSYSRSHSRSRSRSNSHSRQRFSFRGRDHQRGFFRGRGG 1258
            :..:....||.|.|..|:..|.|.||:|..:. |.||.:|.|.||:|.|.|
Mouse   892 RENAREAKRSESGSPRRDTSRENQRSQSRVKD-SSSREKSRSRSRERESDR-------------- 941

  Fly  1259 LRLNYRNQQFHNRPFQHYGQNYHQNQNYHHQHNQHQNYFPPNQHGQHQQYFQRPKRRELPRYDVR 1323
                                                                ..:|||
Mouse   942 ----------------------------------------------------EAQRRE------- 947

  Fly  1324 NVVGTSRHQTQAKDRYGRDAMRSHRSRSGRRNSRSFSRSVSRDSRVSLRSRS---GSPKRRSFSM 1385
                             ||     |.|..||.|||.|||.| .||:..:|:|   |..:|.::|
Mouse   948 -----------------RD-----RERRARRWSRSRSRSRS-PSRLRTKSKSSSFGRNERDNYS- 988

  Fly  1386 SPTPPPGTSPPPHKHGRGRQTSTNRRYARSPSPAPSPRNERATSPVQSVHSRRSRSHTPNRINGD 1450
                           .|.::..||..:.   .|..:.|..|..|..|:.::|..:    |.|..|
Mouse   989 ---------------PRWKERWTNDGWR---CPRGNDRYRRNDSEKQNENTRNEK----NDITAD 1031

  Fly  1451 GNRSSLYMGSPHYTPRISRSRSRSRSKSPKDMHKKKKKKSDKKKRRKRTGSSSPTTAARMRRISR 1515
            .|..|              |..:.||..|..:.:|.....|                      .|
Mouse  1032 SNDPS--------------STDKHRSDCPSWVTEKINSGPD----------------------PR 1060

  Fly  1516 QRDPFEDADDFLAPQRKRKKAGITTGQWSPSPSPGRCDFLHDSALQDKNSSWTPPL---GTPKGG 1577
            .|:| |...|....:.:.:.:|   ..|:.:..||                |....   |..||.
Mouse  1061 TRNP-EKLKDSHWEENRNENSG---NSWTKNFGPG----------------WMSSRGRGGRGKGA 1105

  Fly  1578 HYNNDGGLTPKKTKRKRDKSKKKRKQHQLEKPRKEKKRKRRTQTPEPLPSKEVFASGNNILVSVS 1642
            :..|..         ..|:|                  :.|.|:..||...:.|.|
Mouse  1106 YRGNFA---------CNDQS------------------ENRWQSRTPLSGSDSFKS--------- 1134

  Fly  1643 FNKESNTNNASATLSSQQQSVVTIPPGREDLLSNRMTSMTSMASMASNSNICSAVG-AVKKTKRK 1706
                          :.||.|            ..:.....|..:.|..|...||.. ||:||.
Mouse  1135 --------------AEQQPS------------KRKSEQELSFGTAADRSGWTSASSWAVRKTL-- 1171

  Fly  1707 RKKLEAKPVAIIDLERSPFQVHQEPADVIVLTDSEDATEPLSSRRERE---------RDRDHELM 1762
                                    ||||          :...|||.|.         |..:....
Mouse  1172 ------------------------PADV----------QSYYSRRGRNSSGPQSGWMRQEEETPE 1202

  Fly  1763 RENGQREKTPQVGSLDAIMETSYENMTQSTGPKTPPEPPLVKF----NLPTKKIQHKVRNNPLHE 1823
            :::..:::|.||......:.....:|:....|...|.||:..|    .||...:  .::.||.
Mouse  1203 QDSNLKDQTNQVDGSQLPVNMMQPHMSVMQPPVNAPHPPVGVFPYPVGLPAPMM--NMQRNPF-- 1263

  Fly  1824 DVDDINSADELEASCSMAPAEQTPQHGHASHDGGQKIGPNTPPESGPCSPDAYDPFEPTKSPSLS 1888
                           :|.|  ..|.|.|......|...|.:.|: ||..|       |...||
Mouse  1264 ---------------TMHP--PMPLHLHTGVPLMQVAAPASIPQ-GPPPP-------PPPPPS-- 1301

  Fly  1889 PRSPTLTPSQNLDQQTVSMPASGAIGPGSGDKGESDGAHVTGSNASTNTQAQGNALNPVDLVMAL 1953
                          |.||..||           :.||..|.|
Mouse  1302 --------------QQVSYVAS-----------QPDGKQVQG----------------------- 1318

  Fly  1954 MNKPNQSGSIQQESEVSSAQYISSSSLSLSLGVGSSTGGGGGGAGGGDNHDKTADGKTITVLSNV 2018
                           :|||.::|::
Mouse  1319 ---------------LSSASHVSNN---------------------------------------- 1328

  Fly  2019 LLTSSSVVSSSQHIPSISSPTPPSKKLTPLPKAGGSVASSSSGVGNIPTTSSGIGGTRNGSGLGN 2083
                    .::|.:|:.|:          .|...|||...||                     ||
Mouse  1329 --------MNTQVLPAPSA----------APANTGSVQGPSS---------------------GN 1354

  Fly  2084 AGGSSNALDDSFSMEIESPYSPGSADYEDLFEPPIPLEASRRAKGGATGGKVEIFDNLFGSSSPI 2148
            ...||:                              ::||..|
Mouse  1355 TSSSSH------------------------------VQASNAA---------------------- 1367

  Fly  2149 SNIRMTSRYNTAVGKKSNRTKADRKSKVKGARNPDFYDDVPNSATDLQNKDRLLRKLNRQERVVE 2213
                    ...|..|.|.|.:|...|                |.||        :||..||:..:
Mouse  1368 --------VKLAESKVSVRVEASADS----------------SRTD--------KKLQIQEKAAQ 1400

  Fly  2214 EVKLVLKPYFNKKAITKDDYKDIMRRAVPKICHSRSGEINPHKIKNLIDAYVRKFRAKHKK 2274
            ||||.:||::..|.|||::||:|:|:||.|:|||:|||:|..|:.||:.|||.|:|...||
Mouse  1401 EVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKYRYSRKK 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2926	NP_649554.1	zf-RING_2	155..196	CDD:290367	19/40 (48%)
CG2926	NP_649554.1	PHD_PHRF1	246..291	CDD:277011	6/44 (14%)
Scaf11	XP_006521493.1	mRING-HC-C3HC3D_SCAF11	40..82	CDD:319550	19/41 (46%)
		PRK12678	787..>1023	CDD:237171	82/365 (22%)
		DEC-1_N	1236..>1425	CDD:368028	77/445 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0825
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.790