DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2926 and PHRF1

DIOPT Version :9

Sequence 1:NP_649554.1 Gene:CG2926 / 40676 FlyBaseID:FBgn0037344 Length:2296 Species:Drosophila melanogaster
Sequence 2:NP_001273510.1 Gene:PHRF1 / 57661 HGNCID:24351 Length:1649 Species:Homo sapiens


Alignment Length:2373 Identity:512/2373 - (21%)
Similarity:766/2373 - (32%) Gaps:945/2373 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 SHSDSDSVPRKSTRKLRNRYGPRSDCSSSG-SDIDQLPTRTRKRKKVESSDEEEPERT----PNA 127
            |..||||           .:|..:|....| |:.:.|..|:      .|.|.|:...|    ...
Human    42 SGDDSDS-----------EHGDGTDGEDEGASEEEDLEDRS------GSEDSEDDGETLLEVAGT 89

  Fly   128 VGRIQPMPADPDDGFSSDISSNDLLEKCPICLLTFRQQEIGTPATCEHIFCAACIDAWSRNVQTC 192
            .|:::.         :...:|:|..|.|||||..||.|.:|||..|.|.||..||..||:|..:|
Human    90 QGKLEA---------AGSFNSDDDAESCPICLNAFRDQAVGTPENCAHYFCLDCIVEWSKNANSC 145

  Fly   193 PIDRIEFDRIIVRDSYASRRVVREVRLDLSKSNTELVVDDEADTAALSEEEVTNCEICESPDRED 257
            |:||..|..|.:|..:.. :::|::.::.:|::.|             ||:.|.||:|...||||
Human   146 PVDRTLFKCICIRAQFGG-KILRKIPVENTKASEE-------------EEDPTFCEVCGRSDRED 196

  Fly   258 VMLLCDSCNQGYHMDCLDPPLYEIPAGSWYCDNC------IDSDDEDDNEQLELADDLDQLYEDI 316
            .:||||.|:.||||:||||||.|:|...|:|..|      :.:|....:|     :::..|..|:
Human   197 RLLLCDGCDAGYHMECLDPPLQEVPVDEWFCPECAAPGVVLAADAGPVSE-----EEVSLLLADV 256

  Fly   317 RGMGLPET-RLRVREVQEPPRILRTRQNERIRAAVLRRTRSGA-----------TSAEDSTLTRT 369
                :|.| |||.| ......|.||||:||:||.|.|...|.|           :|..|..:...
Human   257 ----VPTTSRLRPR-AGRTRAIARTRQSERVRATVNRNRISTARRVQHTPGRLGSSLLDEAIEAV 316

  Fly   370 RTRTTTTTTTTTTTTRRTTTSTKKRPVQRRRRRRTRYRTYVVEYDLNNFDEKFALKTSKKVIRRR 434
            .|..:|.......|.|  |.:.:||..:||::...|.:|    ....:...|.:...|||  |:.
Human   317 ATGLSTAVYQRPLTPR--TPARRKRKTRRRKKVPGRKKT----PSGPSAKSKSSATRSKK--RQH 373

  Fly   435 RRRRRRGVATASSEGPGRRLSASKRLAEQMGVK-----------------SEGFQSSHLSGGTAS 482
            |.::||| ....||...|     .|:|..:|::                 |.|...:.:.   |:
Human   374 RVKKRRG-KKVKSEATTR-----SRIARTLGLRRPVHSSCIPSVLKPVEPSLGLLRADIG---AA 429

  Fly   483 SFSLFGNANDLEYFSDSEPDAVSQIS--SA---GLGSTAVQTS---VRIGSIGAPRIRKALLQGK 539
            |.||||:..:|:.|..||..:.:.:|  ||   .|..:|:|:.   .|..|:|..|.|       
Human   430 SLSLFGDPYELDPFDSSEELSANPLSPLSAKRRALSRSALQSHQPVARPVSVGLSRRR------- 487

  Fly   540 ARIAAPPTAPTSAPAADILSSILDLQDRWHDASRNLGEVHIRADGTLNIPQRPAPTATEAPLPKA 604
            ...|.|.......|..|:|.|||..|......|   .:|.|..||:|: .:|.||.:.:.   .:
Human   488 LPAAVPEPDLEEEPVPDLLGSILSGQSLLMLGS---SDVIIHRDGSLS-AKRAAPVSFQR---NS 545

  Fly   605 GT-SKTE---KHLTQAPLYQQG--GGGPNYNRGGGAGSSDSYNNRYSGNTSYRGGGGGGAGGSSG 663
            |: |:.|   |...|......|  ..||:.||....|.|....:|....|:          |:..
Human   546 GSLSRGEEGFKGCLQPRALPSGSPAQGPSGNRPQSTGLSCQGRSRTPARTA----------GAPV 600

  Fly   664 GSGVPSSSGEASSRHLTGEGDGQGGGGFGNQNFSSSGSNNNTNMSSFIPFHLRFNTPTRQQQPRQ 728
            ...:|::.|...:|:|                       :|.::..|...|              
Human   601 RLDLPAAPGAVQARNL-----------------------SNGSVPGFRQSH-------------- 628

  Fly   729 QNVLPANQPTPPFPGSAPPPAPVASSSNNFSGQTPMFAAPLNHHPAPVMGMPVVLSIPPPPMPPA 793
                     :|.|.|:.....|:||:::..|.:        :..|      |....:|.||:.||
Human   629 ---------SPWFNGTNKHTLPLASAASKISSR--------DSKP------PCRSVVPGPPLKPA 670

  Fly   794 SLPWNSPLFKITPLQQAP----AKSNDGNQNDDVDNCPNFSI----------------------Y 832
            .        :.|.:.:.|    .:.:||....|.......||                      .
Human   671 P--------RRTDISELPRIPKIRRDDGGGRRDAAPAHGQSIEIPSACISRLTGREGTGQPGRGT 727

  Fly   833 SQESQA---------VANASAMP-------SGVPHGP---------------------ADASDKD 860
            ..||:|         |...|:.|       |..|.||                     |.:|...
Human   728 RAESEASSRVPREPGVHTGSSRPPAPSSHGSLAPLGPSRGKGVGSTFESFRINIPGNMAHSSQLS 792

  Fly   861 DDDMNEDLVQLDDDDEDTDIPLPLGPEPEPVPEKVPKSSDDDLYEPENPT--------EEPEE-- 915
            ..........:||.::..:.|.||      ...|..|....::|:|.:||        ..||.  
Human   793 SPGFCNTFRPVDDKEQRKENPSPL------FSIKKTKQLRSEVYDPSDPTGSDSSAPGSSPERSG 851

  Fly   916 PEMFEESCDAVPTEKSES-SDHEPSNSNVQAAAPEENDAEEARTRSTPSPLVKEDRAADRDRAKG 979
            |.:       :|:|.:.: |.:.|....|||.....:...|:...:.|.|.:....|..:.|...
Human   852 PGL-------LPSEITRTISINSPKAQTVQAVRCVTSYTVESIFGTEPEPPLGPSSAMSKLRGAV 909

  Fly   980 VLELYDDSDWEELDIDKPKEFEKALLTETEAQVSPKRAPSKRPPSKKDTSLERDVNESGSEHEQD 1044
            ..|...|::.||     |        ||::...:..|.||  ||...|                 
Human   910 AAEGASDTEREE-----P--------TESQGLAARLRRPS--PPEPWD----------------- 942

  Fly  1045 RSYTPCLDEKNLAEEEEAGTTHQNNVSTSPKTRSSKVSGDED---------EPEKAVGTDI-QSE 1099
                           ||.|.:            .|...|.|:         |||.....|: |:.
Human   943 ---------------EEDGAS------------CSTFFGSEERTVTCVTVVEPEAPPSPDVLQAA 980

  Fly  1100 DELNNENESPRRSRSRGTANNKKDKSKSRSKRNKGETFKKVGKRQKDRNYRGDKSEPDRSPRPDS 1164
            .....|...|.||||         .|.|||::                                 
Human   981 THRVVELRPPSRSRS---------TSSSRSRK--------------------------------- 1003

  Fly  1165 RSLTPKMRSKSPRVSKSISRSRSGSRSRCKSKSFSRSRSRSPSRSRNR-RRRNSRSKSYSRSHSR 1228
                   ::|..|||:...|:|||:||..:.:|   |||.|||....| ||:.|::||...|..|
Human  1004 -------KAKRKRVSREHGRTRSGTRSESRDRS---SRSASPSVGEERPRRQRSKAKSRRSSSDR 1058

  Fly  1229 SRSRSNSHSRQRFSFRGRDHQRGFFRGRGGLRLNYRNQQFHNRPFQHYGQNYHQNQNYHHQHNQH 1293
            |.||..: .|::...:.|:|:||                    |:.|                  
Human  1059 SSSRERA-KRKKAKDKSREHRRG--------------------PWGH------------------ 1084

  Fly  1294 QNYFPPNQHGQHQQYFQRPKRRELPRYDVRNVVGTSRHQTQAKDRYGRDAMRSHRSRSGRRNSRS 1358
                                                             :.|:.|||||...|.|
Human  1085 -------------------------------------------------SRRTSRSRSGSPGSSS 1100

  Fly  1359 FSRSVSRDSRVSLRSRSGSPKRRSFSMSPTPPPGTSPPPHKHGRGRQTSTNRRYARSPSPAPSPR 1423
            :....||..:          ||||                                    |..||
Human  1101 YEHYESRKKK----------KRRS------------------------------------ASRPR 1119

  Fly  1424 NERATSPVQSVHSRRSRSHTPNRINGDGNRSSLYMGSPHYTPRISRSRSRSRSKSPKDMHKKKKK 1488
            . |..||..|:.                              |:.|             ||.:::
Human  1120 G-RECSPTSSLE------------------------------RLCR-------------HKHQRE 1140

  Fly  1489 KSDKKKRRKRTGSSSPTTAARMRRISRQRDPFEDADDFLAPQRKRKKAGITTGQWSPSPSPGRCD 1553
            :|.::..||.:             ::..||           :|||:         |.|||...  
Human  1141 RSHERPDRKES-------------VAWPRD-----------RRKRR---------SRSPSSEH-- 1170

  Fly  1554 FLHDSALQDKNSSWTPPLGTPKGGHYNNDGGLTPKKTKRKRDKSKKKRKQHQLEKPRKEKKRKRR 1618
                                              :..:.:|.:|::|..|.:...|  |:|...|
Human  1171 ----------------------------------RAREHRRPRSREKWPQTRSHSP--ERKGAVR 1199

  Fly  1619 TQTPEPLPSKEVFASGNNILVSVSFNKESNTNNASATLSSQQQSVVTIPPGREDLLSNRMTSMTS 1683
            ..:|.||...|                                      ||||||    .|.:.:
Human  1200 EASPAPLAQGE--------------------------------------PGREDL----PTRLPA 1222

  Fly  1684 MASMASNSNICSAVGAVKKTKRKRKKLEAKPVAIIDLERSPFQVHQEPADVI----VLTD-SEDA 1743
            :.....:..:.:|         .:..|:|.||..:..|..|..:..:..|.:    |..| |.||
Human  1223 LGEAHVSPEVATA---------DKAPLQAPPVLEVAAECEPDDLDLDYGDSVEAGHVFDDFSSDA 1278

  Fly  1744 T----EPLSSRRERERDRDHELMRENGQREKTPQVGSLDAIMETSYENMTQSTGPKTPPEPPLVK 1804
            .    :.:||                     .|...|.|:..|..:        |..|..||.  
Human  1279 VFIQLDDMSS---------------------PPSPESTDSSPERDF--------PLKPALPPA-- 1312

  Fly  1805 FNLPTKKIQHKVRNNPLHEDVDDINSADELEASCSMAPAEQTPQHGHASHDGGQKIGPNTPPESG 1869
             :|....||.:|   .|..|.|               |::..|.             |....|..
Human  1313 -SLAVAAIQREV---SLMHDED---------------PSQPPPL-------------PEGTQEPH 1345

  Fly  1870 PCSPDAYDPFEPTKSPSLSPRSPTLTPSQNLDQQTVSMPASGAIGPGSGDKGESDGAHVTGSNAS 1934
            ...|||.:..|...||.::|                              .|:.|          
Human  1346 LLRPDAAEKAEAPSSPDVAP------------------------------AGKED---------- 1370

  Fly  1935 TNTQAQGNALNPVDLVMALMNKPNQSGSIQQ----ESEVSSAQYISSSSL----SLSLGVGSSTG 1991
                                 .|:.||.:|:    |..||....:.|.:|    :.:|....|:.
Human  1371 ---------------------SPSASGRVQEAARPEEVVSQTPLLRSRALVKRVTWNLQESESSA 1414

  Fly  1992 GGGGGAGGGDNHDKTADGKTITVLSNVLLTSSSVVSSSQHIPSISSPTP------PSKKLTP-LP 2049
            .....|.....|......:....:.:|..|....|.|....||...|.|      ||:..:| ||
Human  1415 PAEDRAPRAPLHRPQKPREGAWDMEDVAPTGVRQVFSELPFPSHVLPEPGFPDTDPSQVYSPGLP 1479

  Fly  2050 KAGGSVAS-SSSGVGNIPTTSSGIGGTRNGSGLGNAGGSSNALDDSFSMEIESPYSPGSADYEDL 2113
            .|....:| ....:.:.||....:.|:....|.|.|...:                         
Human  1480 PAPAQPSSIPPCALVSQPTVQFILQGSLPLVGCGAAQTLA------------------------- 1519

  Fly  2114 FEPPIPLEASRRAKGGATGGKVEIFDNLFGSSSPISNIRMTSRYNTAVGKKSNRTKADRKSKVKG 2178
               |:|..                   |..:|.|.|..       ||......:|.|        
Human  1520 ---PVPAA-------------------LTPASEPASQA-------TAASNSEEKTPA-------- 1547

  Fly  2179 ARNPDFYDDVPNSATDLQNKDRLLRKLNRQERVVEEVKLVLKPYFNKKAITKDDYKDIMRRAVPK 2243
                      |..|.:...|:..::||:.|||.||||||.:||::.|:.:||::||||:|:||.|
Human  1548 ----------PRLAAEKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKDILRKAVQK 1602

  Fly  2244 ICHSRSGEINPHKIKNLIDAYVRKFR--AKHKK 2274
            ||||:||||||.|:.||:.|||.|:|  .:|||
Human  1603 ICHSKSGEINPVKVANLVKAYVDKYRHMRRHKK 1635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2926NP_649554.1 zf-RING_2 155..196 CDD:290367 22/40 (55%)
PHD_PHRF1 246..291 CDD:277011 26/44 (59%)
PHRF1NP_001273510.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79 14/53 (26%)
zf-rbx1 92..149 CDD:289448 25/65 (38%)
zf-RING_2 106..149 CDD:290367 23/42 (55%)
PHD_PHRF1 185..230 CDD:277011 26/44 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 324..398 23/87 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..600 18/78 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 644..871 46/261 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 888..1240 130/762 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1281..1395 37/237 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1407..1439 4/31 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1455..1486 10/30 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1526..1556 9/54 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1630..1649 3/6 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159454
Domainoid 1 1.000 222 1.000 Domainoid score I2604
eggNOG 1 0.900 - - E1_KOG0825
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 351 1.000 Inparanoid score I2279
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007147
OrthoInspector 1 1.000 - - oto89986
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12618
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2007
SonicParanoid 1 1.000 - - X6022
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.970

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