DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2926 and Scaf11

DIOPT Version :9

Sequence 1:	NP_649554.1	Gene:	CG2926 / 40676	FlyBaseID:	FBgn0037344	Length:	2296	Species:	Drosophila melanogaster
Sequence 2:	NP_001258099.1	Gene:	Scaf11 / 312030	RGDID:	1598325	Length:	1440	Species:	Rattus norvegicus

Alignment Length:	2302	Identity:	440/2302 - (19%)
Similarity:	670/2302 - (29%)	Gaps:	1018/2302 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 KRKKV--------ESSDEEEPERTPNAVGRIQPMPADPDDGFSSDISSNDLLEKCPICLLTFRQQ 165
            |:|.|        ||.|.|..|...|         ||......|::      ::|||||.....:
  Rat     2 KKKPVYNQSVGDQESEDAEGEENRNN---------ADTSGLLYSEV------DRCPICLSCLLGK 51

  Fly   166 EIGTPATCEHIFCAACIDAWSRNVQTCPIDRIEFDRIIVRDSYASRRVVREVRLDLSKSNTELVV 230
            |:|.|.:|.|:||.|||..|:..:.:|||||..|..:     :..|......::.:.:.:.||
  Rat    52 EVGFPESCNHVFCMACILKWAEILASCPIDRKPFQAV-----FELRAFEGCAKIQVKRRSREL-- 109

  Fly   231 DDEADTAALSEEEVTNCEICESPD------REDVMLLCDSCNQGYHMDCLDPPLYEIPAGSWYCD 289
            ||:.:..:..::.|.: |..:|..      |||  |||
  Rat   110 DDKENEESFKKQLVYH-ESSKSDKRKGNTVRED--LLC--------------------------- 144

  Fly   290 NCIDSDDEDDNEQLELADDLDQLYEDIRGM---GLPETRLRVREVQEPPRILRTRQNERIRAAVL 351
                          |.:|||..||.:....   |.....::..:||        |.|:...:.|
  Rat   145 --------------ERSDDLKVLYRNFSNNKMGGKKNATVKTNKVQ--------RLNQCTDSCV- 186

  Fly   352 RRTRSGATSAEDSTLTRTRTRTTTTTTTTTTTTRRTTTSTKKRPVQRRRRRRTRYRTYVVEYDLN 416
             |:...:.|:.|......||...:.|
  Rat   187 -RSDMPSVSSCDGHSWGPRTYRVSCT--------------------------------------- 211

  Fly   417 NFDEKFALKTSKKVIRRRRRRRRRGVATASSEGPGRRLSASKRLAEQMGVKSEGFQSSHLSGGTA 481
               |...:.....:||::|:..
  Rat   212 ---ESIEVNEINALIRQKRQEL------------------------------------------- 230

  Fly   482 SSFSLFGNANDLEYFSDSEPDAVSQISSAGLGSTAVQTSVRIGSIGAPRIRKALLQGKARIAAPP 546
                      :|.:|.::.|         |.|        |:||:
  Rat   231 ----------ELSWFPNTLP---------GNG--------RVGSV-------------------- 248

  Fly   547 TAPTSAPAA--DILSSILDLQDRWHDASRNLGEVHIRADGTLNIPQRPAPTATEAPLPKAGTSKT 609
              |.|...|  .::||:|                          |:...|.:|.: |...|||
  Rat   249 --PWSVETAVLPLVSSVL--------------------------PRTIFPASTMS-LENFGTS-- 282

  Fly   610 EKHLTQAPLYQQGGG------GPNYNRGG-GAGSSDSYNNRYSGNTSYRGGGGGGAGGSSGGSGV 667
              |...|..:.||||      |.:..||. ...::.:...|.:.||...      ....|..|.|
  Rat   283 --HKGYALAHTQGGGEKKQTSGTSNTRGSRRKPATTAPTRRSTRNTRVE------TVSPSQKSPV 339

  Fly   668 PSSSGEASSRHLTGEGDGQGGGGFGNQNFSSSGSNNNTNMSSFIPFHLRFNTPTRQQQPRQQNVL 732
            |:.|          |.|..|              |:|:::|...|......|   :|.|::::|.
  Rat   340 PNYS----------ECDAPG--------------NSNSSVSISPPAESEKQT---RQAPKRKSVR 377

  Fly   733 PANQPTPPF---PGSAPPPAPVASSSNNFSGQTPMFAAPLNHHPAPVMGMPVVLSIPPPPM--PP 792
            ...:| |..   |..:.|||...:||::....|                   |.|..||.:  ..
  Rat   378 RGRKP-PSLKKKPRKSLPPAEKTTSSDSVEEDT-------------------VDSDTPPVLEKEQ 422

  Fly   793 ASLPWNSPLFKITPLQQ---APAKSNDGNQNDDVDNCPNFSIYSQESQAVANASAMPSGVPHGPA 854
            .|...:|.:..|...::   |....:...|.::.:...|..|  :|...:.|:.   |...:.|.
  Rat   423 QSCVESSSICSIQTDEENHLAKCLESCDEQTEENEQTKNHEI--EEQTEILNSE---SCTQYPPV 482

  Fly   855 DASDKDDDDMNEDLVQLDDDDEDTDIPLPLGPEPEPVPEKVPKSSDDDLYEPENPTEEPEEPEMF 919
            ...:....:..|..|   |:|..||..|. |.:|....|:...||..:: :....||.|.|
  Rat   483 LVGEDSGIEAKELCV---DNDVSTDSSLK-GSDPLENQEQGSGSSGSEV-QASVCTESPPE---- 538

  Fly   920 EESCDAVPTEKSESSDHEPSNSNVQAAAPEENDAEEARTRSTPSPLVKEDRAADRDRAKGVLELY 984
                |.:....|:...|:|      .:.|....:|.|      :|::.::||.| ....|..:|.
  Rat   539 ----DFLTCPPSDIEGHQP------VSGPLGEVSENA------TPVLSDERAED-SLMVGNADLN 586

  Fly   985 DDSDWEELDIDKPK--------------------EFEKALLTETE-AQVSPKRAPSKRPPS---- 1024
            |..:..|..:..||                    :.|...|.:|| .::.|.....:...|
  Rat   587 DSVENTEAFVMSPKVESSEGEITHGLNRHCIPSSDTELPELIQTENTEIIPTCGTLENESSGAVQ 651

  Fly  1025 --------------KKDTSLE-----------------RDVNESGSEHEQDRSYTP-------CL 1051
                          :.|.|||                 ::|.:|.....:|.:.|.       |.
  Rat   652 GCEDTLLKHNLDNTQLDNSLEEKTDSLVEHPIHAELPHKEVEQSEKHFSEDNNETVPMECDSFCS 716

  Fly  1052 DEKNLAEEEEAGTTHQNNVSTSPKTRSSKVSGDEDEPEKAVGTDIQSEDELNNENESPRRSRSR- 1115
            |: |.:|.|.:..|....:|.:..|.||......|...:.|.|..|..:.|.::...||..|||
  Rat   717 DQ-NESEVESSANTDPKQLSENSVTHSSDNKLSSDPVVENVETVAQPAESLVDKAPKPRTRRSRF 780

  Fly  1116 ----GTANNKKD----KSKSRSKRNKGETFKKVGKRQKDRNYRGDKSEPDRSPRPDSRSLTPKMR 1172
                .|.:..||    |.:::|...|.||..:            .||....||:.:|.....|.|
  Rat   781 HSPSTTWSPNKDAAQEKRRAQSPSPKRETAVE------------SKSSQSPSPKRESARGRRKSR 833

  Fly  1173 SKSPRVSKSISRSRSGSRSRCKSKSFSRSRSRSPSRSRNRRRRNSRSKSYSRSHSRSRSRSNSHS 1237
            |.||:  |.:||.|..|||..:..:....||.|.|..|:..|.|.||:|..:. |.||.:|.|.|
  Rat   834 SLSPK--KDVSRERRQSRSPKRENAREAKRSESGSPRRDTSRENQRSQSRVKD-SSSREKSRSRS 895

  Fly  1238 RQRFSFRGRDHQRGFFRGRGGLRLNYRNQQFHNRPFQHYGQNYHQNQNYHHQHNQHQNYFPPNQH 1302
            |:|.|
  Rat   896 RERES------------------------------------------------------------ 900

  Fly  1303 GQHQQYFQRPKRRELPRYDVRNVVGTSRHQTQAKDRYGRDAMRSHRSRSGRRNSRSFSRSVSRDS 1367
                                                 .|||.|  |.|...|.:|.:|||
  Rat   901 -------------------------------------DRDAQR--RDRDRERRARRWSRS----- 921

  Fly  1368 RVSLRSRSGSPKRRSFSMSPTPPPGTSPPPHKHGRGRQTSTNRRYARSPSPAPS-PRNERATSPV 1431
                ||||.||.|                                :|:.|.:.| .||||.|
  Rat   922 ----RSRSRSPSR--------------------------------SRTKSKSSSFGRNERDT--- 947

  Fly  1432 QSVHSRRSRSHTPNRINGDGNRSSLYMGSPHYTPRISRSRSRSRSKSPKDMHKKKKKKSDKKKRR 1496
                                           |:||.....:....:.|:...:.::..|:|:...
  Rat   948 -------------------------------YSPRWREKWTNDGWRCPRGNDRYRRNDSEKQNEN 981

  Fly  1497 KRTGSSSPTTAARMRRISRQRDPF---EDADDFLAPQRKRKKAGITTGQWSPSPSPGRCDFLHDS 1558
            .|......|.       ....||.   :..||  .|....:|  |.:|   |.|.....:.|.||
  Rat   982 TRNEKDDITA-------DNTNDPSSTDKHRDD--CPSWVTEK--INSG---PDPRTRNPEKLKDS 1032

  Fly  1559 ALQD-----KNSSWTPPLGTPKGGHYNNDGGLTPKKTKRKRDKSKKKRKQHQLEKPRKEKKRKRR 1618
            ..::     ..:|||...|.   |..::.|         :..:.|...:.:.....:.|.:.:.|
  Rat  1033 HWEENRNDNSGNSWTKNFGP---GWMSSRG---------RGGRGKGAYRGNFACNDQSENRWQSR 1085

  Fly  1619 TQTPEPLPSKEVFASGNNILVSVSFNKESNTNNASATLSSQQQSVVTIPPGREDLLSNRMTSMTS 1683
            |    ||       ||::...||.       ...|...|.|:.|..| |..|        :..||
  Rat  1086 T----PL-------SGSDSFKSVE-------QQPSKRKSEQELSFGT-PADR--------SGWTS 1123

  Fly  1684 MASMASNSNICSAVGAVKKTKRKRKKLEAKPVAIIDLERSPFQVHQEPADVIVLTDSEDATEPLS 1748
            .:|.           ||:||.                          ||||          :...
  Rat  1124 ASSW-----------AVRKTL--------------------------PADV----------QNYY 1141

  Fly  1749 SRRERERDRDHEL-MRENGQREKTPQVGSLDAIMETSYENMTQSTGPKTPPEPPLVKFNLPTKKI 1812
            |||.|........ ||   |.|:||:   .|:.::.....:..|..|.|..:|.:.... |....
  Rat  1142 SRRGRSSSGPQSAWMR---QEEETPE---QDSNLKDQTNQIDGSQLPVTMLQPHMSVMQ-PPVNA 1199

  Fly  1813 QHK-----------------VRNNPLHEDVDDINSADELEASCSMAPAEQTPQHGHASHDGGQKI 1860
            ||:                 ::.||.                 :|.|  ..|.|.|......|..
  Rat  1200 QHQPVGIFPYPVGVHAPMMNMQRNPF-----------------TMHP--PMPLHLHTGVPLMQVA 1245

  Fly  1861 GPNTPPESGPCSPDAYDPFEPTKSPSLSPRSPTLTPSQNLDQQTVSMPASGAIGPGSGDKGESDG 1925
            .|.:.|: ||                  |..|...|||.:: ...|.|               ||
  Rat  1246 APASIPQ-GP------------------PPPPPPPPSQQVN-YIASQP---------------DG 1275

  Fly  1926 AHVTG----SNASTNTQAQGNALNPVDLVMALMNKPNQSGSIQQESEVSSAQYISSSSLSLSLGV 1986
            ..|.|    |:.|.|...|        ::.|....|..:||:|
  Rat  1276 KQVQGFPSASHVSNNMNTQ--------VLPAPSAAPANTGSVQ---------------------- 1310

  Fly  1987 GSSTGGGGGGAGGGDNHDKTADGKTITVLSNVLLTSSSVVSSSQHIPSISSPTPPSKKLTPLPKA 2051
            |.|:|.                                 .|||.|:.:                |
  Rat  1311 GPSSGN---------------------------------TSSSSHVQA----------------A 1326

  Fly  2052 GGSVASSSSGVGNIPTTSSGIGGTRNGSGLGNAGGSSNALDDSFSMEIESPYSPGSADYEDLFEP 2116
            ..:|..:.|.|                                 |:.:|:     |||
  Rat  1327 NAAVKLAESKV---------------------------------SVTVEA-----SAD------- 1346

  Fly  2117 PIPLEASRRAKGGATGGKVEIFDNLFGSSSPISNIRMTSRYNTAVGKKSNRTKADRKSKVKGARN 2181

  Rat  1347 ----------------------------------------------------------------- 1346

  Fly  2182 PDFYDDVPNSATDLQNKDRLLRKLNRQERVVEEVKLVLKPYFNKKAITKDDYKDIMRRAVPKICH 2246
                    :|.||        :||..||:..:||||.:||::..|.|||::||:|:|:||.|:||
  Rat  1347 --------SSRTD--------KKLQIQEKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCH 1395

  Fly  2247 SRSGEINPHKIKNLIDAYVRKFRAKHK 2273
            |:|||:|..|:.||:.|||.|::...|
  Rat  1396 SKSGEVNSTKVANLVKAYVDKYKYSRK 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2926	NP_649554.1	zf-RING_2	155..196	CDD:290367	19/40 (48%)
CG2926	NP_649554.1	PHD_PHRF1	246..291	CDD:277011	8/50 (16%)
Scaf11	NP_001258099.1	zf-RING_2	39..82	CDD:290367	19/42 (45%)
Scaf11	NP_001258099.1	DEC-1_N	1217..>1387	CDD:282479	68/428 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0825
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.790