Protein Alignment CG2926 and Phrf1

DIOPT Version :9

• Sequence 1: NP_649554.1
• Gene: CG2926 / 40676
• FlyBaseID: FBgn0037344
• Length: 2296
• Species: Drosophila melanogaster
• Sequence 2: XP_006536200.1
• Gene: Phrf1 / 101471
• MGIID: 2141847
• Length: 1715
• Species: Mus musculus
• Alignment Length: 2381
• Identity: 524/2381 - (22%)
• Similarity: 792/2381 - (33%)
• Gaps: 876/2381 - (36%)

  Fly    65 EVASHSDS-DSVPRKSTRKL--------RNRYGPRSDCSSSGSDIDQLPTRTRKRKKVESSDEEE 120
            |:.:||.. |..||..:.:|        ..:.|...|.:.|..|.|     |...:....|:||:
Mouse    26 ELVAHSPGPDGPPRVGSSELASDAEESSNGQSGDSEDDTGSEQDDD-----TDGEETEGLSEEED 85

  Fly   121 PERTPNAVGRIQPMPADPDDGF---------------SSDISSNDLLEKCPICLLTFRQQEIGTP 170
            ||....:        .|.:||.               ||..:|:|..|.|||||..||.|.:|||
Mouse    86 PEDRSGS--------EDSEDGVEMATAAIETQGKLEASSVPNSDDDAESCPICLNAFRDQAVGTP 142

  Fly   171 ATCEHIFCAACIDAWSRNVQTCPIDRIEFDRIIVRDSYASRRVVREVRLDLSKSNTELVVDDEAD 235
            .||.|.||..||..||||..:||:||..|..|.:|..: :.::::::.::.:|:       .||:
Mouse   143 ETCAHYFCLDCIIEWSRNANSCPVDRTVFKCICIRAQF-NGKILKKIPVENTKA-------CEAE 199

  Fly   236 TAALSEEEVTNCEICESPDREDVMLLCDSCNQGYHMDCLDPPLYEIPAGSWYCDNCIDSDDEDDN 300
                 ||:.|.||:|...||||.:||||.|:.||||:||||||.|:|...|:|..|.....:..:
Mouse   200 -----EEDPTFCEVCGRSDREDRLLLCDGCDAGYHMECLDPPLQEVPVDEWFCPECTVPGVDPTH 259

  Fly   301 EQLELAD-DLDQLYEDIRGMGLPET-RLRVREVQEPPRILRTRQNERIRAAVLRRTRSGA----- 358
            :...::| ::..|..|:    :|.| |||.| |.....|.||||:||:||.|.|...|.|
Mouse   260 DAAPVSDEEVSLLLADV----VPTTSRLRPR-VGRTRAIARTRQSERVRATVNRNRISSARRVQH 319

  Fly   359 ------TSAEDSTLTRTRTRTTTTTTTTTTTTRRTTTSTKKRPVQRRR----RRRTRYRTYVVEY 413
                  :|..|.|:....|..:|.......|.|  ..:.:||...||:    |::||.|:.|
Mouse   320 VPRYLMSSLLDETIEAVATGLSTAVYQRPLTPR--VPAKRKRKAGRRKKVLGRKKTRSRSSV--- 379

  Fly   414 DLNNFDEKFALKTSKKVIRRRRRRRRRGVATASSEGPGRRL----SASKRLAEQMGVK------- 467
                        .||....|.::|:.|...|     .||:|    :|..|:|..:|::
Mouse   380 ------------KSKSGSTRAKKRQHRVRKT-----KGRKLKNEVTARSRIARTLGLRRPVRGTS 427

  Fly   468 ----------SEGFQSSHLSGGTASSFSLFGNANDLEYFSDSE---PDAVSQISSAG--LGSTAV 517
                      |.|...:.:.   |:|.||||:..:|:.|..:|   .|..|.:|:..  |..:|:
Mouse   428 MPSVYKPVDPSLGLMRADIG---AASLSLFGDPYELDPFDSNEEQSADPPSPLSAKRRVLSRSAL 489

  Fly   518 QTSVRIGSIGAPRIRKALLQGKARIAAPPTAP----TSAPAADILSSILDLQDRWHDASRNLGEV 578
            |:.        ..:.:.:..|.:|...|..||    ..||..|:|.|||..|.....:|   .:|
Mouse   490 QSH--------QPVARPVAMGLSRRQLPAVAPEPSVEEAPVPDLLGSILSGQSLLMMSS---ADV 543

  Fly   579 HIRADGTLNIPQRPAPTATEAPLPKAGTSKTEKHLTQAPLYQQGGGGPNYNRGGG------AGSS 637
            .|..||:|: .:|.||.:.:.  .....|:.|..|...|   |.|..|:.:..||      ..|.
Mouse   544 VIHRDGSLS-AKRAAPVSLQR--NSVTQSREESRLRDNP---QPGALPSESASGGFVGDRQPNSG 602

  Fly   638 DSYNNRYS--------GNTSYRGGGGGGAGGSSGGSGVPSSSGEASSRHLTGEGDGQGGGGFGNQ 694
            .|..||.:        ..|..|          |..|..|.|   ..||.|:.|..       .::
Mouse   603 LSCGNRTALCCLPARIAQTPVR----------SDPSLTPRS---GLSRTLSDENR-------PSR 647

  Fly   695 NFSSSGSNNNTNM-----SSFIPFHLRF---NTPTRQQQ---PRQQNVLPANQPTPPFPGSAPPP 748
            ..|||...|.:|:     |:.|..|..|   ||.:...|   ||:          |.|  |..|.
Mouse   648 THSSSPQLNGSNVRVSSASTKIVTHSSFPSKNTASGLPQRTGPRR----------PDF--SKLPR 700

  Fly   749 APVASSSNNFSGQTPMFAAPLNHHPAPVMGMPVVLSIPPPPMPPASLPWNSPLFKITPLQQAPAK 813
            .|......|.|.|.   .||.:.|         ::.:|           ::.:.::|. ::.|.:
Mouse   701 IPKIHRDGNKSTQD---QAPASGH---------IVELP-----------STCISRLTG-REGPGQ 741

  Fly   814 SNDGNQNDDVDNCPNFSIYSQESQAVANASAMPSGVPHG-------------------------- 852
            ...|.    ||:.|: |...||:.:..:.|..|:...||
Mouse   742 PGRGR----VDSEPS-SRGPQETGSHTSGSRPPAPSSHGSLAHLGPSRGKGIGSSFESFRINIPG 801

  Fly   853 -PADASDKDDDDMNEDLVQLDDDDEDTDIPLPLGPEPEPVPEKVPKSSDDDLYEPENPTEEPEEP 916
             .|..|.............:|...:..:.|.||      ...|.||....::|:|.:||
Mouse   802 NTAHCSQLSSPGFCNTFRPVDSKVQRKETPFPL------FSIKKPKQLKSEIYDPFDPT------ 854

  Fly   917 EMFEESCDAVPTEKSESSDHEPSNSNVQAAAPEENDAEEART---RSTPSPLVKEDRAADRDRAK 978
                            .||..|.:|:.::..|....:|..||   .|..:|..:..|.....|.:
Mouse   855 ----------------GSDSSPPSSSPESLGPGLLPSEITRTISINSPKAPAFQTVRCVTSYRVE 903

  Fly   979 GVLELYDDSDWEELDIDKPKEFEKALLTETEAQVSPKRAPSKRPPSKKDTSLERDVNESGSEHEQ 1043
            .:..                       ||.|        |..:|||:..:.:...:::..:|...
Mouse   904 SIFG-----------------------TEME--------PEPQPPSEPVSGMLELLSKGSAEGTS 937

  Fly  1044 DRSYTPCLDEKNLAEEEEAGTTHQNNVSTSPKTRSSKVSGDEDEPEKAVGTDIQSEDELNNENES 1108
            |      |:::.|.|.|..    :...||:...|.......:||.|.:......||:
Mouse   938 D------LEQEGLGEIEPT----EIRGSTARTQRPPPPDPWDDEDEVSCTPFFGSEE-------- 984

  Fly  1109 PRRSRSRGTANNKKDKSKSRSKRNKGETFKKVGKRQKDRNYRGDKSEPDRSPRPDSRSLTPKMRS 1173
              |:.:..|.                                   .||...|.||:..:|
Mouse   985 --RTVTCVTV-----------------------------------EEPGVLPSPDAPQIT----- 1007

  Fly  1174 KSPRVSKSISRSRSGSRSRCKSKSFSRSRSRSPSRSRNRRRRNSRSKSYSRSHSRSRSRSNSHSR 1238
                 :..|...|:.            |||||.|.||:|::...:.|..:|.|.|:||.:.|.||
Mouse  1008 -----THRIVEFRAS------------SRSRSTSSSRSRKKTKKKKKKVAREHQRTRSSTRSGSR 1055

  Fly  1239 QRFSFR----GRDHQRGFFRGRGGLRLNYRNQQFHNRPFQHYGQNYHQNQNYHHQHNQHQNYFPP 1299
            .|.|..    ..:|.|                       :|..:...:..:.....:|
Mouse  1056 DRTSRSVSPVAEEHTR-----------------------RHRAKTKSRRSSSDRASSQ------- 1090

  Fly  1300 NQHGQHQQYFQRPKRRELPRYDVRNVVGTSRHQTQAKDRYGRDAMRSHRSRS---GRRNSRSFSR 1361
                      .|.|||                    |||..||  |.||..|   ||...:|
Mouse  1091 ----------DRAKRR--------------------KDRDDRD--REHRRGSWGHGRCRRKS--- 1120

  Fly  1362 SVSRDSRVSLRSRSGSPKRRSFSMSPTPPPGTSPPPHKHGRGRQTSTNRRYARSPSPAPSPRNER 1426
                      ||||||             ||:|.......:.|:    ||::.|.|...|...:|
Mouse  1121 ----------RSRSGS-------------PGSSSCERHESKRRK----RRHSGSRSRGSSLERDR 1158

  Fly  1427 ATSPVQSVHSRRSRSHTPNRINGDGNRSSLYMGSPHYTPRISRSRSRSRSKSPKDMH-------K 1484
                 :..|..|||..               |.......| ||.|.|.||:||...|       :
Mouse  1159 -----RHKHRERSRER---------------MDKQESVTR-SRERRRWRSRSPSLEHRPRRPPSR 1202

  Fly  1485 KKKKKSDKKKRRKRTGSSSPTTAARMRRISRQRDPFEDADDFLAPQRKRKKAGITTGQWSPSPSP 1549
            :|:..|.:||...|..|.:|.|....|         :|.|....|...           ..|..|
Mouse  1203 EKRAHSPEKKGPVREVSPAPATQGESR---------QDGDHSAEPPVS-----------EVSVLP 1247

  Fly  1550 GRCDFLHDSALQDKNSSWTPPLGTPKGGHYNNDGGLTPKKTKRKRDKSKKKRKQHQLEKPRKEKK 1614
            .....|.:..:.|.|....||:......|...|
Mouse  1248 EVVSVLPEVVVADLNPPEVPPVLAEPVAHVPED-------------------------------- 1280

  Fly  1615 RKRRTQTPEPLPSKEVFASGNNILVSVSFNKESNTNNASATLSSQQQSVVTIPPGREDLLSNRMT 1679
                ....|.:.:..||...:|..:.:..:..|:..:..:|.||.::.   .||          .
Mouse  1281 ----LDYGESVEAGHVFEDFSNEAIFIQLDDMSSPPSPESTDSSPERD---FPP----------N 1328

  Fly  1680 SMTSMASMASNSNICSAVGAVKKTKRKRKKLE------AKPV--AIIDLERSPFQVHQEPADVIV 1736
            .:...||:..:|.:.:.         :|:.|.      :|||  |:...::|  .:.|:..::..
Mouse  1329 PILPPASLPQDSTLPTI---------QREVLPIHSEDISKPVPQALAPSDQS--LLKQDTVEITT 1382

  Fly  1737 LTDSEDATEPLSSRRERERDRDHELMRENGQREKTPQVGSLDAIMETSYENMTQSTGPKTPPEPP 1801
            .|.|..|..|::        :|..::...|.....|:    ||:.:.                 |
Mouse  1383 TTPSTPAVVPMT--------KDSPVLSARGWEAVRPR----DAVAQA-----------------P 1418

  Fly  1802 LVKFNLPTKKI----QHKVRNNPLHEDVD---DINSADELEASCSMAPAE--QTPQHGHASHDGG 1857
            |::.....|::    |....:.|...|.|   .......|....|..|.:  |.||.|....:..
Mouse  1419 LLRSRTLVKRVTWNLQEAEHSTPAALDRDPRLTTRHPHSLSVGSSGTPLQRPQRPQEGDWDAEDR 1483

  Fly  1858 QKIG------PNTPP------ESGPCSPDAYDPFEPTKSPSLSPRSPTLTPSQNLDQQTVSMPAS 1910
            ..||      ...||      |||  .||| ||.:|..:|                 :...:||:
Mouse  1484 ALIGFQQAPFSELPPPIHVLQESG--LPDA-DPSQPPGAP-----------------RAEGLPAA 1528

  Fly  1911 GAIGPGSGDKGESDGAHVTGSNASTNTQAQGNALNPVDLVMALMNKPNQSGSIQQESEVSSAQYI 1975
            |.:....|                               ::|.:..||....:.|.|.:.....:
Mouse  1529 GTLHSAGG-------------------------------ILAQVYSPNMPPPLAQPSSILPYALV 1562

  Fly  1976 SSSSLSLSLGVGSSTGGGGGGAGGGDNHDKTADGKTITVLSNVLLTSSSVVSSSQHIPSISSPTP 2040
            |..|:.|.|                       .|
Mouse  1563 SQPSVQLIL-----------------------QG------------------------------- 1573

  Fly  2041 PSKKLTPLPKAGGSVASSSSGVGNIPTTSSGIGGTRNGSGLGNAGGSSNALDDSFSMEIESPYSP 2105
                  .||.||...|.|.:.|..:|.|.|.:
Mouse  1574 ------TLPLAGCGTAQSLAPVPTMPATVSEL--------------------------------- 1599

  Fly  2106 GSADYEDLFEPPIPLEASRRAKGGATGGKVEIFDNLFGSSSPISNIRMTSRYNTAVGKKSNRTKA 2170
                                                   :.|.:|   .|...||
Mouse  1600 ---------------------------------------AVPTTN---NSEERTA---------- 1612

  Fly  2171 DRKSKVKGARNPDFYDDVPNSATDLQNKDRLLRKLNRQERVVEEVKLVLKPYFNKKAITKDDYKD 2235
                             .|.:|.:...|:..::||:.|||.||||||.:||::.|:.:||::|||
Mouse  1613 -----------------TPKTAAEKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKD 1660

  Fly  2236 IMRRAVPKICHSRSGEINPHKIKNLIDAYVRKFR--AKHKK 2274
            |:|:||.|||||:||||||.|:.||:.|||.|:|  .:|||
Mouse  1661 ILRKAVQKICHSKSGEINPVKVANLVKAYVDKYRHMRRHKK 1701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2926	NP_649554.1	zf-RING_2	155..196	CDD:290367	24/40 (60%)
		PHD_PHRF1	246..291	CDD:277011	26/44 (59%)
Phrf1	XP_006536200.1	mRING-HC-C3HC3D_PHRF1	125..168	CDD:319549	25/42 (60%)
		PHD_PHRF1	205..250	CDD:277011	26/44 (59%)
		PHA03307	579..>791	CDD:223039	59/275 (21%)
		PHA03247	<1306..1614	CDD:223021	83/573 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849823
Domainoid	1	1.000	224	1.000	Domainoid score	I2553
eggNOG	1	0.900	-	-		E1_KOG0825
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2199
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007147
OrthoInspector	1	1.000	-	-		oto93562
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12618
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2007
SonicParanoid	1	1.000	-	-		X6022
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.970