DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and dpysl2a

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_003199094.1	Gene:	dpysl2a / 798555	ZFINID:	ZDB-GENE-100914-5	Length:	573	Species:	Danio rerio

Alignment Length:	603	Identity:	286/603 - (47%)
Similarity:	381/603 - (63%)	Gaps:	62/603 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KKVPIHLQSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMII 73
            |.:|   :...:|:.||..:|||.|:||.||:|:|||:||.:|  ..:.:||||:.|:|.|.|:|
Zfish     8 KNIP---RITSDRLLIKGAKIVNDDQSFHADIYMEDGVIKQIG--ENLIVPGGVKIIEAHGRMLI 67

  Fly    74 PGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKV 138
            |||||.||..|:|..|..|.||||.||:||:|||||||:|.|:|....|:|.|:::||.|||.|.
Zfish    68 PGGIDVHTRFQMPDRGMTAADDFYQGTRAALAGGTTMIMDHVVPEPGFSLISAFNQWREWADQKS 132

  Fly   139 CCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAM 203
            ||||.|||.||.|.|.:.|||.:|.|:.|||||..::|||.::|||||.:.:||..||.|..:|.
Zfish   133 CCDYSLHVDITEWHKGLQEEIEMLVKDHGVNSFLVYLAYKDIFQLNDSQMYEVFSVIRDLGAIAQ 197

  Fly   204 VHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAG 268
            ||||||||||:..:|:|..||.|||||.||||||||||||:||..:|:|.:||||:..||||||.
Zfish   198 VHAENGDIIAEEQKRILGLGITGPEGHVLSRPEEVEAEAVNRAVTIANQTNCPLYITKVMSKSAA 262

  Fly   269 IELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLAND 333
            ..:|:||.  :|..:.||.::|:||||.|......:...||.:.||||.||.|||::|..|||..
Zfish   263 DVIAQARK--KGTVVYGEPISASLGTDGTHYWSKNWAKAAAFITSPPLSPDPTTPDYLNSLLACG 325

  Fly   334 DLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAA 398
            |||:|||.:||||...:|:||.:||.||.|.||.|:|||::|:|.|..|.:|..:||.|||||||
Zfish   326 DLQVTGSAHCTFNTSQRAVGKDNFTFIPEGTNGTEERMSIIWDKCVVTGKMDENQFVLVTSTNAA 390

  Fly   399 KIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICA 463
            ||||:||:|||||||||||:|:|:|:||:.||..:||.|.::||||||.|.|....|:.:|::..
Zfish   391 KIFNLYPRKGRIAVGSDADLVLWDPDATKIISAKSHHLAVEYNIFEGMEVRGAPLVVISQGKVVL 455

  Fly   464 ERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELDIQIPVQEPI 528
            |.||:...||.||:|.....|.:||..|:.:                  .|.|||
Zfish   456 EEGNLHTTEGSGRYISRKPFPDYVYKRIKAR------------------SRLAEL---------- 492

  Fly   529 SAMLAGNLAMPA---EGSLCS---TPSVRGRV-DGK-----------RDLQESSFSIS--EELDR 573
                   ..:|.   :|.:|.   ||.|...| .||           |:|.:|.||:|  :..|.
Zfish   493 -------RGVPRGLYDGPVCEVTVTPKVMTPVTSGKTSPVKPAPQPVRNLHQSGFSLSGAQVDDN 550

  Fly   574 SGVRACIKVKNPPGGKSS 591
            ...|...::..||||:::
Zfish   551 VPRRTTQRIVAPPGGRAN 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	251/452 (56%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	254/458 (55%)
dpysl2a	XP_003199094.1	PRK09060	18..468	CDD:181632	251/453 (55%)
dpysl2a	XP_003199094.1	D-HYD	18..467	CDD:238639	251/452 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	501	1.000	Domainoid score	I338
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm24326
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980