DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and Dpysl5

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001343877.1	Gene:	Dpysl5 / 65254	MGIID:	1929772	Length:	564	Species:	Mus musculus

Alignment Length:	584	Identity:	279/584 - (47%)
Similarity:	358/584 - (61%)	Gaps:	30/584 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHT 81
            ||..|:.||.|::||.|.:.:||||||.|||:.||  .|:.||||.:.|||:|.::||||||..|
Mouse     5 SASVRILIKGGKVVNDDCTHEADVYIESGIIQQVG--RELMIPGGAKVIDATGKLVIPGGIDTST 67

  Fly    82 HMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGLHV 146
            |....|..|..|||||||||||:.|||||||..|||:|..|::|||:|.|:.|||||||||.|||
Mouse    68 HFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVEAYEKCRALADPKVCCDYALHV 132

  Fly   147 GITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENGDI 211
            |||||:..|..|:..|.:|.|||||:.||.||.||.|.||:|..||...|.:..:..||||||::
Mouse   133 GITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVFHACRDIGAIPRVHAENGEL 197

  Fly   212 IAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARARH 276
            :|:..:..|..||.||||.|:|.|||:||||.||...:|::..||:|:|:|.|.|||..:|.|
Mouse   198 VAEGAKEALDLGITGPEGIEISHPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAA-- 260

  Fly   277 RYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTGSD 341
            :.:|:.::.||..|..........|..:...||:|..||||.|..|..:||.|||||.|.:..||
Mouse   261 KMQGKVVLAETTNAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASD 325

  Fly   342 NCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQ 406
            :..|..:.||:||.||||||:||:||:||||:|||:||..|.:|..|||||||:|||||.|:||:
Mouse   326 HRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVVWERGVVGGKMDENRFVAVTSSNAAKILNLYPR 390

  Fly   407 KGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVA 471
            ||||..|:|||:|:|:|.||:|||..|.....|||::|.|..|||....:.|||:..|.|....|
Mouse   391 KGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCA 455

  Fly   472 EGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAEL-DIQI---PVQEPISAML 532
            ||.|:|.|....|..||..:         .|.|:........|...| |:.|   |.::.:...|
Mouse   456 EGTGKFCPLRSFPDIVYKKL---------VQREKTLKVRGVDRTPYLGDVAIVVHPGKKEMGTPL 511

  Fly   533 AGNLAMPAEGSLCSTPSVRGRVDGKRDLQESSFSISEEL--DRSGVRACIKVKNPPGGKSSGFW 594
            |.....|..           |..|.|||.|||||:|...  |....||..::..||||:|||.|
Mouse   512 ADTPTRPVT-----------RHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	238/452 (53%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	241/458 (53%)
Dpysl5	NP_001343877.1	D-HYD	10..459	CDD:238639	238/452 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10263
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54576
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm42405
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.780