DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and Dpys

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_113893.2	Gene:	Dpys / 65135	RGDID:	68376	Length:	519	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	284/514 - (55%)
Similarity:	355/514 - (69%)	Gaps:	26/514 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPG----GVRTIDASGLMIIPGGIDP 79
            |.|:.|:.|.:||.|.|..|||.:|||:::.:|  .::..||    |:|.:||:|.:::|||||.
  Rat     4 QERLLIRGGRVVNDDFSQVADVLVEDGVVRALG--RDLLPPGDTSRGLRILDAAGKLVLPGGIDT 66

  Fly    80 HTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGL 144
            |||||.||.|:.:||||:.|||||:||||||||||.:|.|..|:|||::.||:||||||||||.|
  Rat    67 HTHMQFPFMGSQSVDDFHQGTKAALAGGTTMIIDFAIPQKGSSLIEAFETWRNWADPKVCCDYSL 131

  Fly   145 HVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENG 209
            ||.:||||..|.||:..|.::.||||||.|||||.||.:.|..:...|.:.:.:..:|.||||||
  Rat   132 HVAVTWWSDKVKEEMKTLAQDKGVNSFKMFMAYKDLYMVQDQQMYAAFSQCKEIGAIAQVHAENG 196

  Fly   210 DIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARA 274
            |:||:..:::||.||.|||||||.|||.|||||..||..:|...:||||:||||||||...:|.|
  Rat   197 DLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYIVHVMSKSAAKVIADA 261

  Fly   275 RHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTG 339
            :.  .|:.:.||.:||.||||.|...:..:...|.||:.||||||.:||.|||.||||.||..||
  Rat   262 KR--EGKVVYGEPIAAGLGTDGTQYWNKEWRHAAHHVMGPPLRPDPSTPGFLMNLLANGDLTTTG 324

  Fly   340 SDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIY 404
            |||||||...|||||.|||||||||||||||||::||||||:|.:|..|||||||||||||||:|
  Rat   325 SDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLY 389

  Fly   405 PQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVR 469
            |:|||||||||||||||:|.||||||..|||.|.:|||||||..|||....:.|||:..|.|...
  Rat   390 PKKGRIAVGSDADIVIWDPEATRTISAKTHHQAVNFNIFEGMVCHGVPLVTISRGRVVYEAGVFD 454

  Fly   470 VAEGFGRFIPTPVRPPFVYDIIEGKVQS------------------QPEEQHEEKQNGS 510
            |..|.|:|||......|:|..::.:.|:                  :|.|..|:...|:
  Rat   455 VTAGHGKFIPRQPFAEFIYKRVKQRDQTCTPIPVKRAPYKGEVITLKPRETKEDDTAGT 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	271/456 (59%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	275/462 (60%)
Dpys	NP_113893.2	D-HYD	7..460	CDD:238639	271/456 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336704
Domainoid	1	1.000	514	1.000	Domainoid score	I303
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20359
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1027
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm44469
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	LDO	PTHR11647
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770