DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and Dpys

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001157938.1	Gene:	Dpys / 64705	MGIID:	1928679	Length:	519	Species:	Mus musculus

Alignment Length:	486	Identity:	286/486 - (58%)
Similarity:	345/486 - (70%)	Gaps:	14/486 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVG----PSSEITIPGGVRTIDASGLMIIPGGIDP 79
            |.|:.|:.|.|||.|.|..|||.:|||:::.:|    |..:.:  .|:|.:||:|.:::|||||.
Mouse     4 QGRLLIRGGRIVNDDFSQVADVLVEDGVVRALGRDLLPPEDAS--RGLRILDAAGKLVLPGGIDT 66

  Fly    80 HTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGL 144
            |||||.||.|:.:|||||.|||||:||||||||||.:|.|..|:|||::.||:||||||||||.|
Mouse    67 HTHMQFPFMGSQSVDDFYQGTKAALAGGTTMIIDFAIPQKGSSLIEAFETWRNWADPKVCCDYSL 131

  Fly   145 HVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENG 209
            ||.:||||..|.||:..|.::.||||||.||||||||.:.|..|...|.:.:.:..:|.||||||
Mouse   132 HVAVTWWSDKVKEEMKTLARDKGVNSFKMFMAYKGLYMVQDEQLYAAFSQCKEIGAIAQVHAENG 196

  Fly   210 DIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARA 274
            |:||:..:::||.||.|||||||.|||.|||||..||..:|...:|||||||||||||...:|.|
Mouse   197 DLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYVVHVMSKSAAKVVADA 261

  Fly   275 RHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTG 339
            |.  .|..:.||.:||.||||........:...|.||:.||||||..||.|||.||||.||..||
Mouse   262 RR--AGNVVYGEPIAAGLGTDGRQYWSEEWSHAAHHVMGPPLRPDPLTPGFLMDLLANGDLTTTG 324

  Fly   340 SDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIY 404
            |||||||...|||||.|||||||||||||||||::||||||:|.:|..|||||||||||||||:|
Mouse   325 SDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLY 389

  Fly   405 PQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVR 469
            |:|||||||||||||||:|.|||.||..|||.|.:|||||||..|||....:.|||:..|.|...
Mouse   390 PKKGRIAVGSDADIVIWDPEATRRISAKTHHQAVNFNIFEGMVCHGVPLVTISRGRVVYEAGVFN 454

  Fly   470 VAEGFGRFIPTPVRPPF---VYDIIEGKVQS 497
            |..|.|:|||   |.||   :|..|:.:.|:
Mouse   455 VTAGHGKFIP---RQPFAEYIYKRIKQRDQT 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	274/456 (60%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	278/462 (60%)
Dpys	NP_001157938.1	D-HYD	7..460	CDD:238639	274/456 (60%)
Dpys	NP_001157938.1	PRK09060	7..447	CDD:181632	270/443 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833141
Domainoid	1	1.000	514	1.000	Domainoid score	I318
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20359
Inparanoid	1	1.050	563	1.000	Inparanoid score	I1075
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1869
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm42405
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	LDO	PTHR11647
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5547
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750