DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and dpysl2b

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_005155688.1	Gene:	dpysl2b / 553412	ZFINID:	ZDB-GENE-031105-1	Length:	643	Species:	Danio rerio

Alignment Length:	593	Identity:	281/593 - (47%)
Similarity:	384/593 - (64%)	Gaps:	39/593 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KKVPIHLQSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMII 73
            |::..:|....:|:.||..:|||.|:||.||:|:|||:||.:|  ..:.:||||:||||.|.|::
Zfish    75 KELLQNLNDESDRLLIKGAKIVNDDQSFCADIYMEDGLIKQIG--ENLIVPGGVKTIDAHGRMVM 137

  Fly    74 PGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKV 138
            |||||.||..|:|..|..|.||||.||:||:|||||||:|.|:|....|:|.|:::||.|||.|.
Zfish   138 PGGIDVHTRFQMPDRGMTAADDFYQGTRAALAGGTTMIVDHVVPEPGTSLISAFNQWREWADSKA 202

  Fly   139 CCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAM 203
            ||||.|||.||.|.|.|.||:..|.|:.|||||..::|||..:||.||.:.:||..||.|..:|.
Zfish   203 CCDYSLHVDITEWHKGVQEEMEALVKDHGVNSFLVYLAYKDFFQLTDSQIYEVFSVIRDLGAIAQ 267

  Fly   204 VHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAG 268
            ||||||||||:..:|:|..||.|||||.||||||||||||:|:..:|:|.:||||:..||||||.
Zfish   268 VHAENGDIIAEEQRRILDLGITGPEGHVLSRPEEVEAEAVNRSVTVANQTNCPLYITKVMSKSAA 332

  Fly   269 IELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLAND 333
            ..:|:||.  :|..:.||.:.|::|||.:......:...||:|.||||.||.|||::|..||:..
Zfish   333 DVIAQARK--KGTVVYGEPITASIGTDGSHYWSKNWAKAAAYVTSPPLSPDPTTPDYLNSLLSCG 395

  Fly   334 DLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAA 398
            |||:|||.:||||...:|:||.|||.||.|.||.|:|||::|:|.|..|.:|..:||||||||||
Zfish   396 DLQVTGSAHCTFNTSQRAVGKDDFTLIPEGTNGTEERMSIIWDKCVVTGKMDENQFVAVTSTNAA 460

  Fly   399 KIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICA 463
            ||||:||:|||||||||||:|:|:|:.|:.||..:|:.|.::||||||.|.||...|:.:|:|..
Zfish   461 KIFNLYPRKGRIAVGSDADLVLWDPDVTKIISAKSHNLAVEYNIFEGMEVRGVPLVVISQGKIVL 525

  Fly   464 ERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELDIQIP---VQ 525
            |.|.:...||.||||.....|.:||..|:.:                  .|.|||. .:|   ..
Zfish   526 EEGTLHTTEGSGRFISRKPFPDYVYKRIKAR------------------SRLAELR-GVPRGLYD 571

  Fly   526 EPISAMLAGNLAMPAEGSLCSTPSVRGRVDGK--RDLQESSFSIS-----EELDRSGVRACIKVK 583
            .|:..:.....|:....|..::|:   :..|:  |:|.:|.||:|     :.:.|...:   ::.
Zfish   572 GPVCEVSVTPKAVTPASSAKTSPA---KQPGQPVRNLHQSGFSLSGAQVDDNIPRRNTQ---RIV 630

  Fly   584 NPPGGKSS 591
            .||||:::
Zfish   631 APPGGRAN 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	249/452 (55%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	253/458 (55%)
dpysl2b	XP_005155688.1	PRK09060	88..538	CDD:181632	249/453 (55%)
dpysl2b	XP_005155688.1	D-HYD	88..537	CDD:238639	249/452 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	501	1.000	Domainoid score	I338
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm24326
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880