DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRMP and dpysl5b

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001018351.1	Gene:	dpysl5b / 553410	ZFINID:	ZDB-GENE-050720-4	Length:	568	Species:	Danio rerio

Alignment Length:	587	Identity:	254/587 - (43%)
Similarity:	356/587 - (60%)	Gaps:	41/587 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHTHMQL 85
            |:.||.|.:||.|.:.:||||:|:|.|:.||  .::.||||.:.|||:|.::||||||...|:..
Zfish    10 RILIKGGRVVNDDVTEEADVYLENGRIQQVG--RDLMIPGGAKVIDATGKLVIPGGIDSSVHLHQ 72

  Fly    86 PFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGLHVGITW 150
            .|..|...||||.|||||:.||:||:|..|||::..|:::|:::.|:.||.|.||||.||||:||
Zfish    73 TFMNAHTQDDFYSGTKAALLGGSTMLISHVLPDRGASLLDAFEQMRAHADAKACCDYALHVGVTW 137

  Fly   151 WSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENGDIIAKN 215
            |...|..|:.:|..|.|||||:.|||||....|.||:|.......:::..:|.:|||||:::.:.
Zfish   138 WGPKVEREMEVLVGERGVNSFQMFMAYKDAMMLKDSELYQALNTCKNIGAIARIHAENGELVLEG 202

  Fly   216 TQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARARHRYRG 280
            .:..|..||:||||.|:|||||:||||.|||..:.::|.||:|:|:|.|.||...:..|  |.:|
Zfish   203 AKEALDLGISGPEGMEISRPEELEAEATHRAITIGNRAHCPVYLVNVSSMSAADVIGAA--RMQG 265

  Fly   281 RYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTGSDNCTF 345
            :.:..||..|..........|..:...||||::||||.|..||:.|:.||.||.:.:..||:..|
Zfish   266 KVVQAETTVAHAVLSGMHYYHQDWAHAAAHVIAPPLRLDPNTPDHLIGLLGNDIINVVASDHRAF 330

  Fly   346 NKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQKGRI 410
            :.:.||:||.||||||:|..|||||||::||:||.:|.:|..|||||||:|||||:|:||:||||
Zfish   331 STKQKAMGKEDFTKIPHGAPGVEDRMSVIWERGVVSGKMDENRFVAVTSSNAAKIYNLYPRKGRI 395

  Fly   411 AVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVAEGFG 475
            ..|:|||:|:|:|:||||||..|.....|||:|||...|||....:.|||:..|.|....|:|.|
Zfish   396 MPGADADVVVWDPDATRTISASTQAQGGDFNLFEGQRCHGVPLVTISRGRLVCENGVFMCAQGSG 460

  Fly   476 RFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELDIQIPVQEPISAMLAGNLAM-- 538
            :|.|....|.|:|                        |:..:.:..:.|:....|..:|::|.
Zfish   461 KFYPMRAFPDFLY------------------------KKLIQREKTLAVRGVDRAPYSGDVASVM 501

  Fly   539 --------PAEGSL-CSTPSVRGRVDGKRDLQESSFSIS--EELDRSGVRACIKVKNPPGGKSSG 592
                    ..||.: ..|.:...|..|.|||.|||||:|  :..|....|:..::..||||:|||
Zfish   502 SSIRKESGSPEGDVPMRTAATAARHTGIRDLHESSFSLSGAQVDDHIPKRSSARILAPPGGRSSG 566

  Fly   593 FW 594
            .|
Zfish   567 IW 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	218/452 (48%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	221/458 (48%)
dpysl5b	NP_001018351.1	D-HYD	11..460	CDD:238639	218/452 (48%)
dpysl5b	NP_001018351.1	PRK09060	12..451	CDD:181632	215/442 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10619
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm24326
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840