DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and dpysl3

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_012814256.2	Gene:	dpysl3 / 448103	XenbaseID:	XB-GENE-944729	Length:	665	Species:	Xenopus tropicalis

Alignment Length:	595	Identity:	291/595 - (48%)
Similarity:	393/595 - (66%)	Gaps:	33/595 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SPKPVKKVPIHL-QSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDA 67
            |..|.|:...:| :...:|:.||.|.|||.|:||.||:|:|||:||.:|  ..:.:||||:||:|
Frog    92 STTPGKEALQNLDEKESDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIG--DNLIVPGGVKTIEA 154

  Fly    68 SGLMIIPGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRS 132
            :|.|:||||||.|||:|:|:.|...||||:.|||||:|||||||:|.|:|....|:.||::|||.
Frog   155 NGKMVIPGGIDVHTHLQMPYRGMTTVDDFFQGTKAALAGGTTMIVDHVIPEPEASLTEAFEKWRE 219

  Fly   133 WADPKVCCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRH 197
            |||.|.||||.|||.||.|:.||.:|:..|.|:.|||||..:||||.|||:::::|.:||..:..
Frog   220 WADGKTCCDYSLHVDITHWNDSVKQEVEALVKQKGVNSFMVYMAYKDLYQMSNTELYEVFTFLGG 284

  Fly   198 LNGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHV 262
            |..:|.||||||||||:...|:|..||.|||||.||||||:|||||.||..:|.|.:|||||..|
Frog   285 LGAIAQVHAENGDIIAQEQNRMLELGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLYVTKV 349

  Fly   263 MSKSAGIELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLM 327
            ||||:...:::||.  :|..:.||.:.|:||||.|......:...||.|.||||.||.|||:::.
Frog   350 MSKSSVDLISQARK--KGYVVFGEPITASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYIN 412

  Fly   328 KLLANDDLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAV 392
            .|||:.|||:|||.:.||:...||:||.:||.||.|.||:|:|||::|:|.|..|.:|..:||||
Frog   413 SLLASGDLQVTGSAHATFSTAQKAIGKDNFTLIPEGTNGIEERMSVIWDKAVATGKMDENQFVAV 477

  Fly   393 TSTNAAKIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLV 457
            ||||||||||:||:|||||||||:|:|||:|:|.:.:|..:||.|.::||||||.:.|....|:.
Frog   478 TSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDAVKIVSAKSHHSAAEYNIFEGMELRGAPLVVIC 542

  Fly   458 RGRICAERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQ---NGSMAKRFAELD 519
            :|:|..|.|.:.|.:|.|||||....|.:||..|  |.:::..|.|...:   :|
Frog   543 QGKIMMEDGTLHVTQGTGRFIPCSPFPDYVYKRI--KARTKMAELHAVPRGMYDG---------- 595

  Fly   520 IQIPVQEPISAMLAGNLAMPAEGS-LCSTPSVRGRVDGKRDLQESSFSIS-EELDRSGVR-ACIK 581
               ||.:..|...||..|...:|| ...|..|       |:|..|.||:: .:.|.|||| |..:
Frog   596 ---PVYDLASTPKAGTPAGSTKGSPTKQTAPV-------RNLHHSGFSLAGNQGDESGVRSASRR 650

  Fly   582 VKNPPGGKSS 591
            :..||||:|:
Frog   651 IVAPPGGRSN 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	247/452 (55%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	252/458 (55%)
dpysl3	XP_012814256.2	D-HYD	111..560	CDD:238639	247/452 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10090
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	596	1.000	Inparanoid score	I955
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm47515
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5547
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110