DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRMP and Dpysl3

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_006254732.1	Gene:	Dpysl3 / 25418	RGDID:	2410	Length:	683	Species:	Rattus norvegicus

Alignment Length:	610	Identity:	291/610 - (47%)
Similarity:	386/610 - (63%)	Gaps:	54/610 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SPKPVKKVPIHLQSA------QN--------RVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSS 54
            ||||   ..:.::||      ||        |:.||.|.|||.|:||.||:|:|||:||.:|  .
  Rat   101 SPKP---AGVEIRSATGKEVLQNLGPKDKSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIG--D 160

  Fly    55 EITIPGGVRTIDASGLMIIPGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNK 119
            .:.:||||:||:|:|.|::|||||.|||.|:|:.|...||||:.|||||:|||||||||.|:|..
  Rat   161 NLIVPGGVKTIEANGKMVMPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEP 225

  Fly   120 HESMIEAYDKWRSWADPKVCCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLN 184
            ..|:.|||:|||.|||.|.||||.|||.||.|:.||.:|:..|.||.|||||..:||||.|||::
  Rat   226 ESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLSKEKGVNSFMVYMAYKDLYQVS 290

  Fly   185 DSDLLDVFERIRHLNGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVL 249
            :::|.::|..:..|..:|.||||||||||:...|:|..||.|||||.||||||:|||||.||..:
  Rat   291 NTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITV 355

  Fly   250 AHQADCPLYVVHVMSKSAGIELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSP 314
            |.|.:|||||..||||||...:::||.  :|..:.||.:.|:||.|.|......:...||.|.||
  Rat   356 ASQTNCPLYVTKVMSKSAADLISQARK--KGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSP 418

  Fly   315 PLRPDKTTPEFLMKLLANDDLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGV 379
            ||.||.|||:::..|||:.||||:||.:|||:...||:||.:||.||.|.||||:|||::|:|.|
  Rat   419 PLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAV 483

  Fly   380 HAGLLDPCRFVAVTSTNAAKIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFE 444
            ..|.:|..:||||||||||||||:||:|||||||||:|:|||:|:|.:.:|...|....::||||
  Rat   484 ATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDAVKIVSAKNHQSVAEYNIFE 548

  Fly   445 GMTVHGVCEFVLVRGRICAERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNG 509
            ||.:.|....|:.:|:|..|.||:.|.:|.|||||......:||..|:.:
  Rat   549 GMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKAR--------------- 598

  Fly   510 SMAKRFAELD------IQIPVQEPISAMLAGNLAMPAEGS-LCSTPSVRGRVDGKRDLQESSFSI 567
               ::.|:|.      ...||.:..:....|..|....|| ....|.|       |:|.:|.||:
  Rat   599 ---RKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSTRGSPTRPNPPV-------RNLHQSGFSL 653

  Fly   568 SEELDRSGVRACIK-VKNPPGGKSS 591
            |......|||:..| :..||||:|:
  Rat   654 SGTQVDEGVRSASKRIVAPPGGRSN 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	249/452 (55%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	254/458 (55%)
Dpysl3	XP_006254732.1	D-hydantoinase	130..584	CDD:273937	253/457 (55%)
Dpysl3	XP_006254732.1	PRK09060	130..580	CDD:181632	249/453 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	514	1.000	Domainoid score	I303
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1027
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm44469
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880