DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and Dpysl4

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_037065.1	Gene:	Dpysl4 / 25417	RGDID:	2409	Length:	572	Species:	Rattus norvegicus

Alignment Length:	597	Identity:	282/597 - (47%)
Similarity:	370/597 - (61%)	Gaps:	50/597 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KKVPIHLQSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMII 73
            |.:|   :...:|:.||.|:|||.|:||.||:|:|||:||.:|  ..:.:|||::||||.|||::
  Rat     7 KSIP---RITSDRLLIKGGKIVNDDQSFHADLYVEDGLIKQIG--ENLIVPGGIKTIDAHGLMVL 66

  Fly    74 PGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKV 138
            |||:|.||.:|:|..|....|||..|||||:|||||||:|.|.|:...|::.||::||..||...
  Rat    67 PGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDAGVSLLAAYEQWRERADSAA 131

  Fly   139 CCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAM 203
            ||||.|||.|..|.:|..||:..|.::.|||||..|||||...|..|..:.::|..||.|..||.
  Rat   132 CCDYSLHVDIPRWHESTKEELEALVRDKGVNSFLVFMAYKDRCQCTDGQIYEIFSLIRDLGAVAQ 196

  Fly   204 VHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAG 268
            ||||||||:.:..:|||.:||.|||||.||.|||||||||:||..:|.||:||||:..||||.|.
  Rat   197 VHAENGDIVEEEQKRLLEQGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYITKVMSKGAA 261

  Fly   269 IELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLAND 333
            ..:|:|:.  ||..:.||.:.|:||||.:......:...||.|.|||:.||.||.:.|..||::.
  Rat   262 DMVAQAKR--RGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPINPDPTTADHLTSLLSSG 324

  Fly   334 DLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAA 398
            |||:|||.:|||....||:||.:||.||.|:||:|:|||:||||.|.:|.:|...||||||||||
  Rat   325 DLQVTGSAHCTFTTAQKAVGKDNFTLIPEGINGIEERMSVVWEKCVASGKMDENEFVAVTSTNAA 389

  Fly   399 KIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICA 463
            ||||.||:|||:|||||||:|||||.||:.||..:|:...::|||||:...|:...|:.:||:..
  Rat   390 KIFNFYPRKGRVAVGSDADLVIWNPRATKVISAKSHNLNVEYNIFEGVECRGMPTVVISQGRVVL 454

  Fly   464 ERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELD------IQI 522
            |.||:.|..|.|||||....|.|||..|:.:                  .|.||:.      ...
  Rat   455 EDGNLLVTPGAGRFIPRKTFPDFVYKRIKAR------------------NRLAEIHGVPRGLYDG 501

  Fly   523 PVQEPISAMLAGNLAMPAEGSLCSTPSVRGRVDGK------RDLQESSFSI--SEELDRSGVRAC 579
            ||.|   .||.   |.|..|:     ..|....||      |:|.:|.||:  |:..|....|..
  Rat   502 PVHE---VMLP---AKPGSGT-----QARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTA 555

  Fly   580 IKVKNPPGGKSS 591
            .|:..||||:|:
  Rat   556 QKIMAPPGGRSN 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	241/452 (53%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	246/458 (54%)
Dpysl4	NP_037065.1	PRK09060	17..467	CDD:181632	241/453 (53%)
Dpysl4	NP_037065.1	D-HYD	17..466	CDD:238639	241/452 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10052
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1027
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm44469
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.880