DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and Dpysl2

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_006252159.1	Gene:	Dpysl2 / 25416	RGDID:	2517	Length:	673	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	286/604 - (47%)
Similarity:	379/604 - (62%)	Gaps:	51/604 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KKVPIHLQSAQ----------NRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVR 63
            :||.|...|.:          :|:.||.|:|||.|:||.||:|:|||:||.:|  ..:.:||||:
  Rat    95 RKVEIRRASGKEALQNIYDQSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIG--ENLIVPGGVK 157

  Fly    64 TIDASGLMIIPGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYD 128
            ||:|...|:||||||.||..|:|..|..:.|||:.|||||:|||||||||.|:|....|::.|:|
  Rat   158 TIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFD 222

  Fly   129 KWRSWADPKVCCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFE 193
            :||.|||.|.||||.|||.||.|.|.:.||:..|.|:.|||||..:||:|..:||.||.:.:|..
  Rat   223 QWREWADSKSCCDYSLHVDITEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDSQIYEVLS 287

  Fly   194 RIRHLNGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLY 258
            .||.:..:|.||||||||||:..||:|..||.|||||.||||||||||||:|:..:|:|.:||||
  Rat   288 VIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRSITIANQTNCPLY 352

  Fly   259 VVHVMSKSAGIELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTP 323
            |..||||||...:|:||.  :|..:.||.:.|:||||.:......:...||.|.||||.||.|||
  Rat   353 VTKVMSKSAAEVIAQARK--KGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTP 415

  Fly   324 EFLMKLLANDDLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCR 388
            :||..||:..|||:|||.:||||...||:||.:||.||.|.||.|:|||::|:|.|..|.:|..:
  Rat   416 DFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQ 480

  Fly   389 FVAVTSTNAAKIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCE 453
            |||||||||||:||:||:||||:||||||:|||:|::.:|||..||:.|.::||||||...|...
  Rat   481 FVAVTSTNAAKVFNLYPRKGRISVGSDADLVIWDPDSVKTISAKTHNSALEYNIFEGMECRGSPL 545

  Fly   454 FVLVRGRICAERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAEL 518
            .|:.:|:|..|.|.:.|.||.||:||....|.|||..|:.:                  .|.|||
  Rat   546 VVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKAR------------------SRLAEL 592

  Fly   519 D------IQIPVQEPISAMLAGNLAMPAEGSLCSTPSVRGRVDGKRDLQESSFSIS-----EELD 572
            .      ...||.|   ..:......||  |...|...:.:....|:|.:|.||:|     :.:.
  Rat   593 RGVPRGLYDGPVCE---VSVTPKTVTPA--SSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIP 652

  Fly   573 RSGVRACIKVKNPPGGKSS 591
            |   |...::..||||:::
  Rat   653 R---RTTQRIVAPPGGRAN 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	249/452 (55%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	253/458 (55%)
Dpysl2	XP_006252159.1	D-HYD	118..567	CDD:238639	249/452 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	514	1.000	Domainoid score	I303
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1027
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm44469
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880