DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and Crmp1

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001352080.1	Gene:	Crmp1 / 25415	RGDID:	2407	Length:	686	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	277/595 - (46%)
Similarity:	395/595 - (66%)	Gaps:	35/595 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PKPVKKVPIHLQSAQ-NRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDAS 68
            |.| :.:|:...:.| :|:.|:.|.|:|.|:||.||||:|||:||.:|  ..:.:||||:||:|:
  Rat   114 PAP-RDLPLGRDNGQSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIG--ENLIVPGGVKTIEAN 175

  Fly    69 GLMIIPGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSW 133
            |.|:||||||.:|::|.|..|..:.|||:.||:||:|||||||||.|:|....|::.:::||...
  Rat   176 GRMVIPGGIDVNTYLQKPSQGMTSADDFFQGTRAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEA 240

  Fly   134 ADPKVCCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHL 198
            ||.|.||||.|||.||.|...|.||:.:|.::.|||||:.:||||.|||::||.|.:.|..::.|
  Rat   241 ADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTFLKGL 305

  Fly   199 NGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVM 263
            ..|.:|||||||:||:..:|:|..||.|||||.||||||:|||||.||..:|.:.:||:|:..||
  Rat   306 GAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRINCPVYITKVM 370

  Fly   264 SKSAGIELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMK 328
            ||||...:|.||.  :|..:.||.:||:||||.|......:...||.|.||||.||.|||::|..
  Rat   371 SKSAADIIALARK--KGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTS 433

  Fly   329 LLANDDLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVT 393
            |||..|||:|||.:|.::...||:||.:||.||.||||:|:||::||:|.|..|.:|..:|||||
  Rat   434 LLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVT 498

  Fly   394 STNAAKIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVR 458
            |||||||||:||:|||||||||||:|||:|:..:|::..:|....::||||||..||....|:.:
  Rat   499 STNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTLTAKSHKSTVEYNIFEGMECHGSPLVVISQ 563

  Fly   459 GRICAERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELDI-QI 522
            |:|..|.||:.|::|.|||||....|..:|..:  :::|:....|      |:::...:..: ::
  Rat   564 GKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRV--RIRSKVFGLH------SVSRGMYDGPVYEV 620

  Fly   523 PVQEPISAMLAGNLAMPAEGSLCSTPSVRGRVDGKRDLQESSFSIS-EELD-----RSGVRACIK 581
            |.....:|        ||. |..|:|| :.:....|:|.:|:||:| .::|     |:|.|
  Rat   621 PATPKHAA--------PAP-SAKSSPS-KHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHR---- 671

  Fly   582 VKNPPGGKSS 591
            :..||||:|:
  Rat   672 IVAPPGGRSN 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	239/452 (53%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	244/458 (53%)
Crmp1	NP_001352080.1	D-HYD	131..580	CDD:238639	239/452 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	514	1.000	Domainoid score	I303
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1027
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm44469
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880