DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and DPYSL2

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001184222.1	Gene:	DPYSL2 / 1808	HGNCID:	3014	Length:	677	Species:	Homo sapiens

Alignment Length:	589	Identity:	279/589 - (47%)
Similarity:	374/589 - (63%)	Gaps:	41/589 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 HLQSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGID 78
            ::....:|:.||.|:|||.|:||.||:|:|||:||.:|  ..:.:||||:||:|...|:||||||
Human   114 NINDQSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIG--ENLIVPGGVKTIEAHSRMVIPGGID 176

  Fly    79 PHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYG 143
            .||..|:|..|..:.|||:.|||||:|||||||||.|:|....|::.|:|:||.|||.|.||||.
Human   177 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 241

  Fly   144 LHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAEN 208
            |||.|:.|.|.:.||:..|.|:.|||||..:||:|..:||.|..:.:|...||.:..:|.|||||
Human   242 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAEN 306

  Fly   209 GDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELAR 273
            |||||:..||:|..||.|||||.||||||||||||:||..:|:|.:||||:..|||||:...:|:
Human   307 GDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQ 371

  Fly   274 ARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLT 338
            ||.  :|..:.||.:.|:||||.:......:...||.|.||||.||.|||:||..||:..|||:|
Human   372 ARK--KGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVT 434

  Fly   339 GSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNI 403
            ||.:||||...||:||.:||.||.|.||.|:|||::|:|.|..|.:|..:|||||||||||:||:
Human   435 GSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNL 499

  Fly   404 YPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNV 468
            ||:|||||||||||:|||:|::.:|||..||:.:.::||||||...|....|:.:|:|..|.|.:
Human   500 YPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTL 564

  Fly   469 RVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELD------IQIPVQEP 527
            .|.||.||:||....|.|||..|:.:                  .|.|||.      ...||.|
Human   565 HVTEGSGRYIPRKPFPDFVYKRIKAR------------------SRLAELRGVPRGLYDGPVCE- 610

  Fly   528 ISAMLAGNLAMPAEGSLCSTPSVRGRVDGKRDLQESSFSIS-----EELDRSGVRACIKVKNPPG 587
              ..:......||  |...|...:.:....|:|.:|.||:|     :.:.|   |...::..|||
Human   611 --VSVTPKTVTPA--SSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPR---RTTQRIVAPPG 668

  Fly   588 GKSS 591
            |:::
Human   669 GRAN 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	246/452 (54%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	250/458 (55%)
DPYSL2	NP_001184222.1	D-HYD	122..571	CDD:238639	246/452 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	520	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1054
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm40339
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880