Protein Alignment CRMP and CRMP1

DIOPT Version :9

• Sequence 1: NP_730954.2
• Gene: CRMP / 40675
• FlyBaseID: FBgn0023023
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_001014809.1
• Gene: CRMP1 / 1400
• HGNCID: 2365
• Length: 686
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 282/595 - (47%)
• Similarity: 389/595 - (65%)
• Gaps: 35/595 - (5%)

  Fly     5 PKPVKKVPIHLQSAQ-NRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDAS 68
            |.| :.:|:...:.| :|:.||.|.|:|.|:|..||||:|||:||.:|  ..:.:||||:||:|:
Human   114 PAP-RDLPLGRDNGQSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIG--ENLIVPGGVKTIEAN 175

  Fly    69 GLMIIPGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSW 133
            |.|:||||||.:|::|.|..|..|.|||:.||:||:.||||||||.|:|....|::.:::||...
Human   176 GRMVIPGGIDVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSFEKWHEA 240

  Fly   134 ADPKVCCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHL 198
            ||.|.||||.|||.||.|...|.||:.:|.::.|||||:.:||||.:||::||.|.:.|..::.|
Human   241 ADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQMSDSQLYEAFTFLKGL 305

  Fly   199 NGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVM 263
            ..|.:|||||||:||:..:|:|..||.|||||.||||||:|||||.||..:|.:.:||:|:..||
Human   306 GAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAITIAGRINCPVYITKVM 370

  Fly   264 SKSAGIELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMK 328
            ||||...:|.||.  :|..:.||.:||:||||.|......:...||.|.||||.||.|||::|..
Human   371 SKSAADIIALARK--KGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTS 433

  Fly   329 LLANDDLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVT 393
            |||..|||:|||.:|.::...||:||.:||.||.||||:|:||::||:|.|..|.:|..:|||||
Human   434 LLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVT 498

  Fly   394 STNAAKIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVR 458
            |||||||||:||:|||||||||||:|||:|:..:||:..:|..|.::||||||..||....|:.:
Human   499 STNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTITAKSHKSAVEYNIFEGMECHGSPLVVISQ 563

  Fly   459 GRICAERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELDIQIP 523
            |:|..|.||:.|.:|.|||||....|..:|..:  |:::        |..|.........|  .|
Human   564 GKIVFEDGNINVNKGMGRFIPRKAFPEHLYQRV--KIRN--------KVFGLQGVSRGMYD--GP 616

  Fly   524 VQE-PISAMLAGNLAMPAEGSLCSTPSVRGRVDGKRDLQESSFSIS-EELD-----RSGVRACIK 581
            |.| |.:.    ..|.||. |..|:|| :.:....|:|.:|:||:| .::|     |:|.|
Human   617 VYEVPATP----KYATPAP-SAKSSPS-KHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHR---- 671

  Fly   582 VKNPPGGKSS 591
            :..||||:|:
Human   672 IVAPPGGRSN 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	240/452 (53%)
		PRK09060	24..483	CDD:181632	245/458 (53%)
CRMP1	NP_001014809.1	PRK09060	131..581	CDD:181632	240/453 (53%)
		D-HYD	131..580	CDD:238639	240/452 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	520	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1054
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm40339
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880