DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and dpysl5

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_031757772.1	Gene:	dpysl5 / 100496348	XenbaseID:	XB-GENE-6073088	Length:	564	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	280/586 - (47%)
Similarity:	367/586 - (62%)	Gaps:	26/586 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IHLQSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGI 77
            :|......|:.||.|::||.|.:.:||||||:|||:.:|  .|:.||||.:.|||:|.::|||||
Frog     1 MHANPPSARILIKGGKVVNDDCTQEADVYIENGIIQQIG--KELMIPGGAKVIDATGKLVIPGGI 63

  Fly    78 DPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDY 142
            |..||....|..|..:||||:|||||:.|||||:|..|.|:|..|:::||:|.||.|||||||||
Frog    64 DTSTHFHQTFMNATCMDDFYNGTKAALMGGTTMVIGHVFPDKDVSLLDAYEKCRSLADPKVCCDY 128

  Fly   143 GLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAE 207
            .||:|:||||..|..|:..|.:|.|||||:.||.||.||.|.||:|..||...:.|..||.||||
Frog   129 ALHMGVTWWSPKVMAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVFRHCKDLGAVARVHAE 193

  Fly   208 NGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELA 272
            |||::|:..:..|..||.||||.|:|||||:||||||||..:|::..||||:|:|.|.|||..:|
Frog   194 NGDLVAEGAKEALELGITGPEGIEISRPEELEAEAVHRAITIANRTFCPLYLVNVSSMSAGDVVA 258

  Fly   273 RARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQL 337
            .|  :.:|:.:.|||..|....:.....|..:...||:|..||||.|..||.:||.|||||.|.:
Frog   259 AA--KMQGKSVYGETTTAHATLNGLHYYHQEWSHAAAYVTVPPLRLDTNTPNYLMSLLANDSLNV 321

  Fly   338 TGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFN 402
            ..||:.||..:.:|:||.||||||:||.||:||||::||:||..|.:|..||||:||:|||||.|
Frog   322 VSSDHRTFTTKQRAMGKEDFTKIPHGVGGVQDRMSVIWERGVVGGKMDENRFVAITSSNAAKIHN 386

  Fly   403 IYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGN 467
            :||:||||..|:|||||:|:|.||||||..|.....|.|::|.|..|||....:..||:..|.|.
Frog   387 MYPRKGRIIPGADADIVVWDPEATRTISASTQVQGGDVNLYENMRCHGVPLVTISHGRVVYENGA 451

  Fly   468 VRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELDIQIPVQEPISAML 532
            ...|||.|.|.|....|.|:|     |...|.|:...:|.          :| :.|.|..::  :
Frog   452 FMCAEGSGCFFPMRTYPDFLY-----KKMVQKEKTSSQKC----------VD-RTPYQGEVA--V 498

  Fly   533 AGNLAMPAEGS-LCSTPS-VRGRVDGKRDLQESSFSIS--EELDRSGVRACIKVKNPPGGKSSGF 593
            ..|......|| :..||: ...|..|.|||.||.||:|  :..|....||..::..||||:|||.
Frog   499 VANSGKKETGSPMADTPTRPTTRHGGMRDLHESGFSLSGAQIDDHVPKRASARILAPPGGRSSGI 563

  Fly   594 W 594
            |
Frog   564 W 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	239/452 (53%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	242/458 (53%)
dpysl5	XP_031757772.1	D-HYD	10..459	CDD:238639	239/452 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11922
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm47515
Panther	1	1.100	-	-	O	PTHR11647
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.110