DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2931 and RBM42

DIOPT Version :9

Sequence 1:	NP_649552.1	Gene:	CG2931 / 40673	FlyBaseID:	FBgn0037342	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_077297.2	Gene:	RBM42 / 79171	HGNCID:	28117	Length:	480	Species:	Homo sapiens

Alignment Length:	461	Identity:	140/461 - (30%)
Similarity:	199/461 - (43%)	Gaps:	181/461 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GTKR-RNIEDELSRFEAEI-------------------SKPPARNLFVPNQ--VRPIIAANTYQN 44
            |.:| :.:|.|::.||.|:                   :.|....:.||..  :|||||.||||.
Human    30 GEERLKEMEAEMALFEQEVLGAPVPGIPTAVPAVPTVPTVPTVEAMQVPAAPVIRPIIATNTYQQ 94

  Fly    45 SQHKLQHHQGNGGSRLTVPPPPMPPPPTFMSTFV-PTGSGGG------SSKAMSA---------- 92
            .|..|   :....:..||.||.:..||     || |.|.|.|      |.:|..|
Human    95 VQQTL---EARAAAAATVVPPMVGGPP-----FVGPVGFGPGDRSHLDSPEAREAMFLRRAAVAP 151

  Fly    93 --TPVV---------------LSSA---PKLYQCR----------------QSVHVPTVAAAPSI 121
              .|::               ||||   |:....|                ..:.:|.:|.||..
Human   152 QRAPILRPAFVPHVLQRADSALSSAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGP 216

  Fly   122 DINAVSFDVTQKLKKLKAEKSGPNPIA----------EEAIKAA-----RASSA----------- 160
            .:.:::     .|:....|.:.|..:.          |||:.||     .||:|
Human   217 PLGSMA-----ALRPPLEEPAAPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAG 276

  Fly   161 ----------------------------------------------------------LQSFQTT 167
                                                                      |.:.:..
Human   277 PAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVP 341

  Fly   168 ERKKKDRK---------TVRIAGGTVWEDTSLADWPDDDFRIFCGDLGNDVNDEVLTRTFNKFPS 223
            |...:|:|         .:|.|.|:.|||.||.:|..||||||||||||:|||::|.|.|::|||
Human   342 EPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPS 406

  Fly   224 FQRARVVRDKRTGKSKGFGFVSFREPADFIRAMKEMDGRYVGSRPIKLRKSTWRQRSLDVVKKKE 288
            |.:|:|:|||||||:||:|||||::|:|::|||:||:|:||||||||||||.|:.|:||||:||:
Human   407 FLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQ 471

  Fly   289 REKQVL 294
            :||:.|
Human   472 KEKKKL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2931	NP_649552.1	RRM_RBM42	192..274	CDD:240829	57/81 (70%)
CG2931	NP_649552.1	RRM	<194..>280	CDD:223796	59/85 (69%)
RBM42	NP_077297.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		140/461 (30%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000250	236..480		90/242 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..356		4/36 (11%)
		RRM_RBM42	375..457	CDD:409817	57/81 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5701
eggNOG	1	0.900	-	-		E1_KOG0226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1221
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249623at2759
OrthoFinder	1	1.000	-	-		FOG0005503
OrthoInspector	1	1.000	-	-		oto90373
orthoMCL	1	0.900	-	-		OOG6_103065
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1762
SonicParanoid	1	1.000	-	-		X3922
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760