DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2931 and Rbm42

DIOPT Version :9

Sequence 1:	NP_649552.1	Gene:	CG2931 / 40673	FlyBaseID:	FBgn0037342	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_001014181.2	Gene:	Rbm42 / 361545	RGDID:	1306184	Length:	478	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	133/446 - (29%)
Similarity:	186/446 - (41%)	Gaps:	157/446 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GTKR-RNIEDELSRFEAEISKPPARNL-----FVPN----------QVRPIIAANTYQNSQ---- 46
            |.:| :.:|.|::.||.|:...|...:     .||.          .:|||||.||||..|
  Rat    34 GEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVEAMQVPPAPVIRPIIATNTYQQVQQTLE 98

  Fly    47 ---------------------------------------------------------------HK 48
                                                                           |.
  Rat    99 ARAAAAATVVPPMVGGPPFVGPVGFGPADRSHLDSPEAREAMFLRRAAVAPQRAPILRPAFVPHV 163

  Fly    49 LQH--------------------HQGNGGSRLTVPP-PPMPPPPTFMSTFVPTGS---------- 82
            ||.                    ||...|..|..|| |||..||...:...|.||
  Rat   164 LQRADSALSSAAGGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEE 228

  Fly    83 -------------------------GGGSSKAMSATPVVLSSAPKLYQCRQSVHVPTVAAA---- 118
                                     ..|..:|.:|..|....||    ...:|..|::..|
  Rat   229 PAAPRDLGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAP----AGPAVIGPSLPLALAMP 289

  Fly   119 -PSIDINAVSFDVTQ---------KLKKLKAEKSGPNPIAEEAIKAARASSALQSFQTTERKKKD 173
             |..:...:..:|.:         :|..|:.....|.|.....:.|......|...:...:.:|.
  Rat   290 LPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKL 354

  Fly   174 RKTVRIAGGTVWEDTSLADWPDDDFRIFCGDLGNDVNDEVLTRTFNKFPSFQRARVVRDKRTGKS 238
            ::.:|.|.|:.|||.||.:|..||||||||||||:|||::|.|.|::||||.:|:|:|||||||:
  Rat   355 KRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKT 419

  Fly   239 KGFGFVSFREPADFIRAMKEMDGRYVGSRPIKLRKSTWRQRSLDVVKKKEREKQVL 294
            ||:|||||::|:|::|||:||:|:||||||||||||.|:.|:||||:||::||:.|
  Rat   420 KGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2931	NP_649552.1	RRM_RBM42	192..274	CDD:240829	57/81 (70%)
CG2931	NP_649552.1	RRM	<194..>280	CDD:223796	59/85 (69%)
Rbm42	NP_001014181.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..209		11/37 (30%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000269\|PubMed:19170760	234..478		96/246 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..354		5/36 (14%)
		RRM_RBM42	373..455	CDD:409817	57/81 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5580
eggNOG	1	0.900	-	-		E1_KOG0226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3439
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249623at2759
OrthoFinder	1	1.000	-	-		FOG0005503
OrthoInspector	1	1.000	-	-		oto97489
orthoMCL	1	0.900	-	-		OOG6_103065
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3922
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830