DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12746 and Plpp5

DIOPT Version :9

Sequence 1:	NP_649551.4	Gene:	CG12746 / 40672	FlyBaseID:	FBgn0037341	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_082276.1	Gene:	Plpp5 / 71910	MGIID:	1919160	Length:	260	Species:	Mus musculus

Alignment Length:	232	Identity:	106/232 - (45%)
Similarity:	143/232 - (61%)	Gaps:	14/232 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 LRVLLVITFFKLETMTAFKREIHEEELWLYKNPR-RPDIVRGGELLFWVIVAPF-LVTIAFYWYT 139
            :||||.:.|...|.:..|:|.|..||||||:||. ..:....|.:.....:.|. |:.:|.:...
Mouse    12 VRVLLFVAFLVTELLPPFQRRIQPEELWLYRNPYVEAEYFPTGRMFVIAFLTPLSLIFLAKFLRK 76

  Fly   140 RDRRDFRAASWAWTLALCMNGIPTSVLKITVGRPRPDYFYRCFPDGVMVLNTTSNGVDTSILDFN 204
            .|..|.:.|..|.:|||.:||:.|:::|:.|||||||:||||||||:            :..|..
Mouse    77 ADATDSKQACLAASLALALNGVFTNIIKLIVGRPRPDFFYRCFPDGL------------AHSDLT 129

  Fly   205 CTGLPGDINEGRKSFPSGHSSFAFASFGFIAYYIGAKLHAFDSRGRGHTWRLCIAVIPLFIALLV 269
            |||....:|||||||||||||||||...|.::|:..|||.|..:|||.:||||..:.||..|.::
Mouse   130 CTGDEDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRLCAFLSPLLFAAVI 194

  Fly   270 AVSRTCDYHHHWQDVTIGGLIGLFAGYISYTQYYPSI 306
            |:||||||.||||||.:|.:||:...|:.|.||||.:
Mouse   195 ALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPL 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12746	NP_649551.4	PAP2_containing_1_like	104..302	CDD:239484	90/199 (45%)
Plpp5	NP_082276.1	PAP2_containing_1_like	39..227	CDD:239484	90/199 (45%)
		Phosphatase sequence motif I. /evidence=ECO:0000250\|UniProtKB:Q8NEB5	104..112		5/7 (71%)
		Phosphatase sequence motif II. /evidence=ECO:0000250\|UniProtKB:Q8NEB5	145..148		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000250\|UniProtKB:Q8NEB5	197..207		8/9 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834810
Domainoid	1	1.000	182	1.000	Domainoid score	I3445
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100569
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3570
Isobase	1	0.950	-	0	Normalized mean entropy	S2488
OMA	1	1.010	-	-		QHG50067
OrthoDB	1	1.010	-	-		D1621899at2759
OrthoFinder	1	1.000	-	-		FOG0001532
OrthoInspector	1	1.000	-	-		otm44063
orthoMCL	1	0.900	-	-		OOG6_100228
Panther	1	1.100	-	-	O	PTHR10165
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3374
SonicParanoid	1	1.000	-	-		X622
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750