Protein Alignment CG12746 and PLPP4

DIOPT Version :10

• Sequence 1: NP_649551.4
• Gene: CG12746 / 40672
• FlyBaseID: FBgn0037341
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: NP_001025230.1
• Gene: PLPP4 / 196051
• HGNCID: 23531
• Length: 271
• Species: Homo sapiens
• Alignment Length: 243
• Identity: 109/243 - (44%)
• Similarity: 152/243 - (62%)
• Gaps: 26/243 - (10%)

  Fly    72 AVDVVLRVLLVITFFKLETMTAFKREIHEEELWLYKNPRRPDIVRGGEL---LFWVIVAPFLVTI 133
            |:::.:|.||...|...|.:..|:|.|..||:||||||    :|:...:   |.:.|  .||..:
Human     5 AIEIGVRALLFGVFVFTEFLDPFQRVIQPEEIWLYKNP----LVQSDNIPTRLMFAI--SFLTPL 63

  Fly   134 AFYWYTR-----DRRDFRAASWAWTLALCMNGIPTSVLKITVGRPRPDYFYRCFPDGVMVLNTTS 193
            |.....:     |:.:.:.|..|.:|||.:||:.|:.:|:.|||||||:||||||||||  |:
Human    64 AVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGVM--NS-- 124

  Fly   194 NGVDTSILDFNCTGLPGDINEGRKSFPSGHSSFAFASFGFIAYYIGAKLHAFDSRGRGHTWRLCI 258
                    :.:|||.|..::||||||||.||||||:..||..:|:..|||.|...|||.:||||.
Human   125 --------EMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCA 181

  Fly   259 AVIPLFIALLVAVSRTCDYHHHWQDVTIGGLIGLFAGYISYTQYYPSI 306
            |::||:.|:::|:||.|||.|||||..:||:|||...||.|.|:||.:
Human   182 AILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHYPPL 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12746	NP_649551.4	PAP2_containing_1_like	104..302	CDD:239484	95/205 (46%)
PLPP4	NP_001025230.1	PAP2_containing_1_like	37..225	CDD:239484	95/205 (46%)
		Phosphatase sequence motif I. /evidence=ECO:0000269|PubMed:17590538	102..110		5/7 (71%)
		Phosphatase sequence motif II. /evidence=ECO:0000269|PubMed:17590538	143..146		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000269|PubMed:17590538	195..205		7/9 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..271