Protein Alignment Pi4KIIalpha and LSB6

DIOPT Version :10

• Sequence 1: NP_730944.2
• Gene: Pi4KIIalpha / 40670
• FlyBaseID: FBgn0037339
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_012435.1
• Gene: LSB6 / 853345
• SGDID: S000003636
• Length: 607
• Species: Saccharomyces cerevisiae
• Alignment Length: 735
• Identity: 195/735 - (26%)
• Similarity: 280/735 - (38%)
• Gaps: 291/735 - (39%)

  Fly   136 EAVLLKRSSNPRNQRLKGSAE-----DSIDSSSQQPPIICHIAPAKVASSALTSPLKTTSHTALA 195
            ||.....:.||..:.:..|.:     |..|....:.| |.|.:|. |.|:|..|.        :|
Yeast     4 EAYQHDHTVNPHQKIVVNSYDWLQFRDEQDHCKSKNP-ITHASPG-VGSNAQNSD--------IA 58

  Fly   196 RHP---HDEADDICLVPEIDFEGMSTDAGSDNRESQPLL------GGGNASHGSRISELLG---- 247
            ..|   |.....:..||.   |....|..|.:..:..||      ..|....||:......
Yeast    59 EAPQVFHPSYQSLVNVPS---ESPRPDQTSGSNPAVGLLHNAEDKASGQEEEGSQYEIQYSVFRP 120

  Fly   248 -------GLG----RGHDHVEFVSNTFGDDPLFSEIVAKAEGAIEN-GVLPERIYQGSSGSYFV- 299
                   ||.    |..:..|...|       |:.:|:....|:|. |...|||..||||||||
Yeast   121 LHAYPTKGLAYEQLRRKEEQEQREN-------FNHLVSDCIEAVETFGRELERIQTGSSGSYFVY 178

  Fly   300 ---KDASHQCLAVFKPKDEEPYGRLNPKWTKWMHKLCCPCCFGRACLIPNQGYLSESGASLVDRK 361
               .|.|.. :.|||||||||||..:||||||.|:...||.|||:|||||.||:.||.|||:||:
Yeast   179 GTRADESVP-VGVFKPKDEEPYGPFSPKWTKWAHRTFFPCLFGRSCLIPNLGYICESAASLLDRR 242

  Fly   362 LNLNVVPKTRVVRLVAESFNYARIDRQKA-----KLKKRIKEHYPSAHFNRMSLPLKTGSFQLFV 421
            |..::||.|....:  ||||:  .|.:|.     .|:|:.::              |.||||||:
Yeast   243 LETHLVPYTDTASI--ESFNF--YDNRKKWVLGYNLQKKKQK--------------KLGSFQLFL 289

  Fly   422 EGYKDADYWLRRFESEPLP----------------------PSVAKS------------------ 446
            :.|.:||.:..::   |||                      |...::
Yeast   290 KEYINADEFFHKY---PLPGMYSDVKHSFHRKSSGEDINHKPETTRNLTDETEPSKQINSSPIST 351

  Fly   447 -----------------FQLQFERLVVLDYIIRNTDRGNDNWLIKYVAPKITTQVGGTGGRTMHG 494
                             |:|:.|:|::||||:||||||.|||::|.:
Yeast   352 ESEENSKFEWTESSLSQFRLELEKLIILDYIMRNTDRGLDNWMVKLI------------------ 398

  Fly   495 VVTPKLPNALGASKIVDLNEPPQASPKPTTGGRPSNHLAGGAATSAQQDSSSLASSEDEPSSRSP 559
                ||.|
Yeast   399 ----KLSN--------------------------------------------------------- 402

  Fly   560 PTSEPDWNVVNSAFIRIAAIDNGLAFPFKHPDSWRAYPYHWAWLPQAKI--PFSEEIKEQVLPQL 622
                      |...:::|||||||:||:||||.||.|||.|.:||...:  ||||:::...||.|
Yeast   403 ----------NKWRLKLAAIDNGLSFPWKHPDEWRLYPYGWLYLPLQLLAKPFSEQMRSHFLPIL 457

  Fly   623 SDMNFVEEICTELLYLFQQDRGFDKRLFERQMSVMRGQILNLTQALRDGK--------------- 672
            :..|:.||...|.|.||.:|:.|:.|::::|.:|::||..|:.:.|:|.:
Yeast   458 TSTNWWEESYQEFLALFSRDQDFNVRMWKKQWAVLKGQAFNVVETLKDPRQGPLELVRRTRCQVI 522

  Fly   673 -----------------------------SPVQLVQMPAVIV-----ERSSGSRFFSFT------ 697
                                         ||:.|...|:.|.     :.:|...::..|
Yeast   523 DEKMQVPCCPPPVSIFKNAIDEPIGSYSTSPMVLPSTPSTIPFHAHNQSNSNPVYYDSTLHPFAN 587

  Fly   698 -----QRFQ--NKSPFFSWC 710
                 :|.|  |.:|.|:||
Yeast   588 KTVIAERLQIVNSTPVFTWC 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIalpha	NP_730944.2	Protein Kinases, catalytic domain	292..>474	CDD:473864	90/247 (36%)
LSB6	NP_012435.1	PI3_PI4_kinase	170..498	CDD:395364	137/438 (31%)