DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIalpha and pi4k2a

DIOPT Version :9

Sequence 1:NP_730944.2 Gene:Pi4KIIalpha / 40670 FlyBaseID:FBgn0037339 Length:710 Species:Drosophila melanogaster
Sequence 2:NP_001263612.1 Gene:pi4k2a / 594904 XenbaseID:XB-GENE-491468 Length:471 Species:Xenopus tropicalis


Alignment Length:566 Identity:270/566 - (47%)
Similarity:329/566 - (58%) Gaps:138/566 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 TSPLKTTSHTALARHPHDEAD-----------DICLVPEIDF----------------------- 213
            ||||.:..        .|:.|           .:||.|...|                       
 Frog     4 TSPLVSPD--------RDQTDYSYQSQCSPGVPVCLSPNGRFSAVPGVVVRIPGSATSPIRGSAA 60

  Fly   214 EGMSTDAGSDNRESQPLLGGGNASHGSRISELLGGLGRGHDHVEFVSNTFGDDPLFSEIVAKAEG 278
            .|.|......:||.||||         ..|:..|...:    .|...|.|.|||.|:|:|.|||.
 Frog    61 SGPSPPGSPCDRERQPLL---------ERSQTRGAAAQ----AERERNKFPDDPEFAEVVKKAEK 112

  Fly   279 AIENGVLPERIYQGSSGSYFVKDASHQCLAVFKPKDEEPYGRLNPKWTKWMHKLCCPCCFGRACL 343
            ||...:|||||.||||||||||:...:.:||||||:|||||:||||||||:.||||||||||.||
 Frog   113 AIVRDILPERISQGSSGSYFVKNEQGEIIAVFKPKNEEPYGQLNPKWTKWLQKLCCPCCFGRDCL 177

  Fly   344 IPNQGYLSESGASLVDRKLNLNVVPKTRVVRLVAESFNYARIDRQKAKLKKRIKEHYPSA--HFN 406
            :.|||||||:||||||:||.||:||:|:||.|.:|:|||:.|||.|::.|:...|..|..  .||
 Frog   178 VLNQGYLSEAGASLVDQKLELNIVPRTKVVFLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFN 242

  Fly   407 RMSLPLKTGSFQLFVEGYKDADYWLRRFESEPLPPSVAKSFQLQFERLVVLDYIIRNTDRGNDNW 471
            |:.||.|.|||||||:|||||||||||||::|||.:..:..||||||||||||||||||||||||
 Frog   243 RIGLPPKVGSFQLFVKGYKDADYWLRRFEADPLPENTNRQLQLQFERLVVLDYIIRNTDRGNDNW 307

  Fly   472 LIKYVAPKITTQVGGTGGRTMHGVVTPKLPNALGASKIVDLNEPPQASPKPTTGGRPSNHLAGGA 536
            ||||..|                                                          
 Frog   308 LIKYDCP---------------------------------------------------------- 314

  Fly   537 ATSAQQDSSSLASSEDEPSSRSPPTSEPDWNVVNSAFIRIAAIDNGLAFPFKHPDSWRAYPYHWA 601
                 .||   ||:.|            ||.:|....|:|||||||||||.||||||||||::||
 Frog   315 -----MDS---ASARD------------DWVMVKEPVIKIAAIDNGLAFPLKHPDSWRAYPFYWA 359

  Fly   602 WLPQAKIPFSEEIKEQVLPQLSDMNFVEEICTELLYLFQQDRGFDKRLFERQMSVMRGQILNLTQ 666
            |||||||.||:|||:.:||::||.|||:::..:|..||::|.|||:..|.:|::|||||||||||
 Frog   360 WLPQAKIQFSQEIKDLILPKISDPNFVKDLEEDLYELFKRDPGFDRGQFRKQIAVMRGQILNLTQ 424

  Fly   667 ALRDGKSPVQLVQMPAVIVERSSG---SRFFSFTQRFQNKSPFFSW 709
            ||:|||||:||||.|.||||.:..   |...|:||.||::.|||||
 Frog   425 ALKDGKSPLQLVQTPPVIVETARSHQKSTSESYTQSFQSRKPFFSW 470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIalphaNP_730944.2 PKc_like 293..>474 CDD:304357 127/182 (70%)
pi4k2aNP_001263612.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 48..101 14/65 (22%)
PI3_PI4_kinase 126..421 CDD:366110 198/372 (53%)
Important for substrate binding. /evidence=ECO:0000250|UniProtKB:Q9BTU6 150..152 1/1 (100%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 158..171 10/12 (83%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 261..269 7/7 (100%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 351..360 6/8 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 438 1.000 Domainoid score I549
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H101681
Inparanoid 1 1.050 524 1.000 Inparanoid score I1222
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002168
OrthoInspector 1 1.000 - - otm48208
Panther 1 1.100 - - LDO PTHR12865
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1894
SonicParanoid 1 1.000 - - X1639
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.090

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