DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIalpha and pi4k2b

DIOPT Version :10

Sequence 1:NP_730944.2 Gene:Pi4KIIalpha / 40670 FlyBaseID:FBgn0037339 Length:710 Species:Drosophila melanogaster
Sequence 2:NP_001016953.1 Gene:pi4k2b / 549707 XenbaseID:XB-GENE-974293 Length:492 Species:Xenopus tropicalis


Alignment Length:583 Identity:277/583 - (47%)
Similarity:345/583 - (59%) Gaps:128/583 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 DSIDSSSQQPPIICHIAPAKVASSALTSPLKTTSHTALA------RHPHDEADDICLVPEIDFEG 215
            |:.||    ||::..:.||....:|.|:||.....:|.|      |...|.|.:           
 Frog     8 DARDS----PPLLVFLEPAAEEVTAHTAPLSPNPQSARAAPGSAVRFFSDSARE----------- 57

  Fly   216 MSTDAGSDNRESQPLL-------------GGGNASHGSRISELLGG-LGRGHDHVEFVSNTFGDD 266
              .:||.|    :|||             |....|..|....:.|| :|.|    ||  |...||
 Frog    58 --EEAGED----EPLLKKSGPVSPRAARKGRTRLSSSSDRENMSGGHVGNG----EF--NVILDD 110

  Fly   267 PLFSEIVAKAEGAIENGVLPERIYQGSSGSYFVKDASHQCLAVFKPKDEEPYGRLNPKWTKWMHK 331
            ..|::|:.:||.|||:||.||||.|||||||||||...:.:.|||||.|||||.|||||||:.||
 Frog   111 LEFADIIHRAEQAIESGVFPERISQGSSGSYFVKDPKGKIIGVFKPKSEEPYGHLNPKWTKYFHK 175

  Fly   332 LCCPCCFGRACLIPNQGYLSESGASLVDRKLNLNVVPKTRVVRLVAESFNYARIDRQKAKLKKRI 396
            :||||||||.||:||||||||:||.|||.||.|.|||||:||.||:|:|||:.|||.|::.||..
 Frog   176 ICCPCCFGRGCLVPNQGYLSEAGAYLVDEKLGLGVVPKTKVVWLVSETFNYSAIDRAKSRGKKYA 240

  Fly   397 KEHYPSA--HFNRMSLPLKTGSFQLFVEGYKDADYWLRRFESEPLPPSVAKSFQLQFERLVVLDY 459
            .|..|..  .|:|:.||.|.|||||||:|||:||||||:||::|||.:..|..|.|||:||:|||
 Frog   241 LEKVPKVGRKFHRIGLPPKVGSFQLFVDGYKEADYWLRKFETDPLPENTRKQLQCQFEKLVILDY 305

  Fly   460 IIRNTDRGNDNWLIKYVAPKITTQVGGTGGRTMHGVVTPKLPNALGASKIVDLNEPPQASPKPTT 524
            :|||||||||||||:|                                                 
 Frog   306 VIRNTDRGNDNWLIRY------------------------------------------------- 321

  Fly   525 GGRPSNHLAGGAATSAQQDSSSLASSEDEPSSRSPPTSEPDWNVVNSAFIRIAAIDNGLAFPFKH 589
                          .:|.|...:...:|.|..        ||..:....|:||||||||||||||
 Frog   322 --------------DSQDDDELMEKGDDFPLK--------DWKEIKEPVIKIAAIDNGLAFPFKH 364

  Fly   590 PDSWRAYPYHWAWLPQAKIPFSEEIKEQVLPQLSDMNFVEEICTELLYLFQQDRGFDKRLFERQM 654
            ||.|||||:|||||||||:|||:|.::.:||::||||||:::|.:|..||:.|:||||..||:||
 Frog   365 PDEWRAYPFHWAWLPQAKVPFSQETRDLILPRISDMNFVQDLCEDLYELFKTDKGFDKATFEKQM 429

  Fly   655 SVMRGQILNLTQALRDGKSPVQLVQMPAVIVERS-SGSR------FFSFTQRFQNKSPFF-SW 709
            ||||||||||||||:|||:|:||||||.|:|||| |||:      ..:|||.|..:.||| ||
 Frog   430 SVMRGQILNLTQALKDGKTPIQLVQMPRVVVERSCSGSQGRIVQMSNAFTQTFHCRKPFFSSW 492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIalphaNP_730944.2 Protein Kinases, catalytic domain 292..>474 CDD:473864 124/183 (68%)
pi4k2bNP_001016953.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..98 26/110 (24%)
G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 133..139 4/5 (80%)
PI3_PI4_kinase 136..438 CDD:395364 195/372 (52%)
Important for substrate binding. /evidence=ECO:0000250|UniProtKB:Q9BTU6 160..162 1/1 (100%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 168..181 9/12 (75%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 271..279 6/7 (86%)
Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 308..316 7/7 (100%)
Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 353..373 18/19 (95%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 368..377 7/8 (88%)

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