DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIalpha and Pi4k2b

DIOPT Version :9

Sequence 1:NP_730944.2 Gene:Pi4KIIalpha / 40670 FlyBaseID:FBgn0037339 Length:710 Species:Drosophila melanogaster
Sequence 2:NP_001005883.1 Gene:Pi4k2b / 305419 RGDID:1359515 Length:477 Species:Rattus norvegicus


Alignment Length:567 Identity:276/567 - (48%)
Similarity:331/567 - (58%) Gaps:123/567 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 SIDSSSQQPPIICHIAPAKVASSALTSP--LKTTSHTALARHPHDEADDICLVPEIDFEGMSTDA 220
            |.|...::.|::..:|.|:....|..|.  |:.....|:.|.|..|.      |.:..|..|..|
  Rat    19 SEDEDEEREPLLPRVAWAQPRRGAPGSAVRLQADQGAAVLREPATEE------PPVVSEDRSISA 77

  Fly   221 GSDNRESQPLLGGGNASHGSRISELLGGLGRGHDHVEFVSNTFGDDPLFSEIVAKAEGAIENGVL 285
            ..    |..|....||     :||               :|||.:||.|:::|.|||.|||.||.
  Rat    78 SL----STELDRTRNA-----VSE---------------TNTFLEDPEFADVVLKAEQAIEIGVF 118

  Fly   286 PERIYQGSSGSYFVKDASHQCLAVFKPKDEEPYGRLNPKWTKWMHKLCCPCCFGRACLIPNQGYL 350
            ||||.|||||||||||:....:.|||||.|||||:|||||||::||:||||||||.||:||||||
  Rat   119 PERISQGSSGSYFVKDSKRTIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLLPNQGYL 183

  Fly   351 SESGASLVDRKLNLNVVPKTRVVRLVAESFNYARIDRQKAKLKKRIKEHYPSA--HFNRMSLPLK 413
            ||:||.|||.||.|.:||||:||.||:|:|||:.|||.|::.||...|..|..  .|:|:.||.|
  Rat   184 SEAGAYLVDTKLQLGIVPKTKVVWLVSETFNYSAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPK 248

  Fly   414 TGSFQLFVEGYKDADYWLRRFESEPLPPSVAKSFQLQFERLVVLDYIIRNTDRGNDNWLIKYVAP 478
            .|||||||:.||:|:|||||||:||||.::.|.||.||||||:||||||||||||||||:||...
  Rat   249 IGSFQLFVKDYKEAEYWLRRFEAEPLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVKYDEM 313

  Fly   479 KITTQVGGTGGRTMHGVVTPKLPNALGASKIVDLNEPPQASPKPTTGGRPSNHLAGGAATSAQQD 543
            |.                         |.||                                  
  Rat   314 KY-------------------------AKKI---------------------------------- 319

  Fly   544 SSSLASSEDEPSSRSPPTSEPDWNVVNSAFIRIAAIDNGLAFPFKHPDSWRAYPYHWAWLPQAKI 608
                   |.|         |.:|.......||||||||||||||||||.|||||:|||||||||:
  Rat   320 -------ESE---------ESNWIDDKQLLIRIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKV 368

  Fly   609 PFSEEIKEQVLPQLSDMNFVEEICTELLYLFQQDRGFDKRLFERQMSVMRGQILNLTQALRDGKS 673
            |||||.:..:||.:||||||:::|.:|..||:.|:|||:..||.|||||||||||||||||||||
  Rat   369 PFSEETRNLILPFISDMNFVQDLCEDLYELFKTDKGFDRAAFESQMSVMRGQILNLTQALRDGKS 433

  Fly   674 PVQLVQMPAVIVERSS----------GSRFFSFTQRFQNKSPFF-SW 709
            |:||.|||.||||.|.          ||   ||||....:.||| ||
  Rat   434 PMQLAQMPCVIVECSKSGGQGRVVHLGS---SFTQTVHCRKPFFSSW 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIalphaNP_730944.2 PKc_like 293..>474 CDD:304357 125/182 (69%)
Pi4k2bNP_001005883.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..80 16/70 (23%)
PI3_PI4_kinase 125..423 CDD:395364 200/372 (54%)
Important for substrate binding. /evidence=ECO:0000250|UniProtKB:Q9BTU6 149..151 1/1 (100%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 157..170 9/12 (75%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 260..268 5/7 (71%)
Important for interaction with membranes. /evidence=ECO:0000250|UniProtKB:Q9BTU6 353..362 7/8 (88%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340868
Domainoid 1 1.000 433 1.000 Domainoid score I558
eggNOG 1 0.900 - - E1_KOG2381
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 515 1.000 Inparanoid score I1248
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002168
OrthoInspector 1 1.000 - - otm45145
orthoMCL 1 0.900 - - OOG6_101496
Panther 1 1.100 - - O PTHR12865
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1639
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.750

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