Protein Alignment Pi4KIIalpha and ZC8.6

DIOPT Version :9

• Sequence 1: NP_730944.2
• Gene: Pi4KIIalpha / 40670
• FlyBaseID: FBgn0037339
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_508849.3
• Gene: ZC8.6 / 180770
• WormBaseID: WBGene00022501
• Length: 593
• Species: Caenorhabditis elegans
• Alignment Length: 660
• Identity: 254/660 - (38%)
• Similarity: 344/660 - (52%)
• Gaps: 157/660 - (23%)

  Fly   133 DGEEAVLLKRSSNPRNQRL--KGSAEDSIDSSSQQPPII----CHIAPAKVASSALTSPLKTTSH 191
            |.|.:.:   |.:.||.|:  .|::|..:::..:...::    ..:...:...:..|:||    |
 Worm     7 DSESSAI---SPSRRNIRMSSSGASESEVETCDENVGLLGSRGKKVKHERSNRAEQTAPL----H 64

  Fly   192 TALARHPHDEADDICLVPEIDFEGMSTDAGSDNRESQPLLGGGNASHGSRISELLGGLGRGHDHV 256
            ..|..|. |||       .|:|.|.| |..........||..|:.::||.:...
 Worm    65 RPLGSHA-DEA-------TIEFGGRS-DYHDPYTSDDELLHTGSDAYGSTVGAT----------- 109

  Fly   257 EFVSNTFGDDPLFSEIVAKAEGAIENGVLPERIYQGSSGSYFVKDASHQCLAVFKPKDEEPYGRL 321
              :|..|.:          |..||.||..|:||.||||||||||:...:.:||||||:|||||.|
 Worm   110 --ISLKFNE----------ACRAIHNGHYPQRIAQGSSGSYFVKNMHDEIIAVFKPKNEEPYGSL 162

  Fly   322 NPKWTKWMHKLCCPCCFGRACLIPNQGYLSESGASLVDRKLNLNVVPKTRVVRLVAESFNYARID 386
            ||||.||:|::..||||||:||.||||||||.||||||.||.|.:||.|.||.|.|.:|.|.|||
 Worm   163 NPKWLKWIHRVFLPCCFGRSCLPPNQGYLSEVGASLVDEKLKLGIVPPTGVVELAAPTFYYDRID 227

  Fly   387 RQKAKLKKRIKEHYPS--AHFNRMSLPLKTGSFQLFVEGYKDADYWLRRFESEP---LPPSVAKS 446
            |.||:.|:||:..||:  ..|:|:.||.|||||||||:||:||.:|||.:.::|   .||...:.
 Worm   228 RAKARTKERIQSRYPNIGRRFHRIGLPEKTGSFQLFVKGYQDAAHWLRTWVNQPETAPPPVTQRE 292

  Fly   447 FQLQFERLVVLDYIIRNTDRGNDNWLIKYVAPKITTQVGGTGGRTMHGVVTP-----KLPNALGA 506
            ||..||:||.|||||||||||:|||||||:...:..:.      .:|....|     ..|...|.
 Worm   293 FQFLFEKLVALDYIIRNTDRGSDNWLIKYILADVIDRA------PVHNNDVPCDPANAKPQVPGD 351

  Fly   507 SKIVDLNEPPQASPKPTTGGRPSNHLAGGAATSAQQDSSSLASSEDEPSSRSPPTSEPDWNVVNS 571
            .|::|..:   :..||..|                     .|...|:|:     .:|.:|..|:.
 Worm   352 EKLIDFVD---SEAKPDAG---------------------TARVVDDPA-----PAEVEWADVSI 387

  Fly   572 AFIRIAAIDNGLAFPFKHPDSWRAYPYHWAWLPQAKIPFSEEIKEQVLPQLSDMNFVEEICTELL 636
            ..:.:|||||||||||||||.|||||:.||.||||:||||::|.:.:||:|.|.|:|.|:|.:|.
 Worm   388 PTVDVAAIDNGLAFPFKHPDEWRAYPFGWALLPQAQIPFSDDIVDLLLPKLDDTNWVRELCGDLR 452

  Fly   637 YLFQQDRGFDKRLFERQMSVMRGQILNLTQALRDGKSPVQLVQMPA------------------- 682
            .:|:.|:||||::||:|||||||||.||.:||...|||.||:|||.
 Worm   453 RVFKNDKGFDKKIFEKQMSVMRGQIFNLREALMKKKSPYQLIQMPPQLMVEVKQKKKKSRRSRNA 517

  Fly   683 ---------------------VIVER-------------------------SSGSRFF--SFTQR 699
                                 |.||:                         :.||:.:  ::.|:
 Worm   518 DYEEAPNYDSDASTVVNTSGNVDVEQPGPSTSAAAAATAGPSTSDAGAASSTGGSKSWQETYEQK 582

  Fly   700 FQNKSPFFSW 709
            .|.|:|||.|
 Worm   583 VQTKAPFFRW 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIalpha	NP_730944.2	PKc_like	293..>474	CDD:304357	116/185 (63%)
ZC8.6	NP_508849.3	PKc_like	133..479	CDD:389743	192/380 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159365
Domainoid	1	1.000	373	1.000	Domainoid score	I473
eggNOG	1	0.900	-	-		E1_KOG2381
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H101681
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1070
Isobase	1	0.950	-	0	Normalized mean entropy	S1915
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002168
OrthoInspector	1	1.000	-	-		oto19162
orthoMCL	1	0.900	-	-		OOG6_101496
Panther	1	1.100	-	-	LDO	PTHR12865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1894
SonicParanoid	1	1.000	-	-		X1639
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.730